Literature DB >> 27086140

Oral Chemotherapy in Patients with Hematological Malignancies-Care Process, Pharmacoeconomic and Policy Implications.

Jeffrey Betcher1, Elizabeth Dow2, Nandita Khera3.   

Abstract

Patients with hematologic malignancies are increasing being prescribed oral anticancer medications (OAMs) and/or biologics. These newer targeted OAMs are associated with a host of practical and pharmacoeconomic implications for patients and healthcare providers. Issues such as safety, procurement challenges, and the need for proactive involvement of all stakeholders to optimize adherence for successful use of these agents are increasingly being recognized. The current reactive model is negatively impacting the patient experience through delays in care, financial toxicity, and decreased safety. It also impacts the healthcare providers in the form of lost revenue and staff burnout due to labor-intensive procurement and patient financial assistance burdens. In this review, we describe some of the issues identified and discuss potential strategies to improve patient access, minimize healthcare burden, and review current policy initiatives and patient advocacy efforts to reduce financial toxicity.

Entities:  

Keywords:  Medication adherence; Oral anticancer drugs; Oral cancer therapy; Oral chemotherapy; Oral parity; Pharmacoeconomics

Mesh:

Substances:

Year:  2016        PMID: 27086140     DOI: 10.1007/s11899-016-0325-2

Source DB:  PubMed          Journal:  Curr Hematol Malig Rep        ISSN: 1558-8211            Impact factor:   3.952


  46 in total

Review 1.  A review of economic impact of targeted oral anticancer medications.

Authors:  Chan Shen; Chun-Ru Chien; Daniel M Geynisman; Fabrice Smieliauskas; Ya-Chen T Shih
Journal:  Expert Rev Pharmacoecon Outcomes Res       Date:  2013-12-30       Impact factor: 2.217

2.  Full disclosure--out-of-pocket costs as side effects.

Authors:  Peter A Ubel; Amy P Abernethy; S Yousuf Zafar
Journal:  N Engl J Med       Date:  2013-10-17       Impact factor: 91.245

3.  The rise and role of specialty pharmacy.

Authors:  David Suchanek
Journal:  Biotechnol Healthc       Date:  2005-10

Review 4.  Adherence to therapy with oral antineoplastic agents.

Authors:  Ann H Partridge; Jerry Avorn; Philip S Wang; Eric P Winer
Journal:  J Natl Cancer Inst       Date:  2002-05-01       Impact factor: 13.506

5.  Patient preferences for oral versus intravenous palliative chemotherapy.

Authors:  G Liu; E Franssen; M I Fitch; E Warner
Journal:  J Clin Oncol       Date:  1997-01       Impact factor: 44.544

Review 6.  Oral antineoplastic agents: how do we care about adherence?

Authors:  Marie Barillet; Virginie Prevost; Florence Joly; Bénédicte Clarisse
Journal:  Br J Clin Pharmacol       Date:  2015-10-28       Impact factor: 4.335

7.  In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.

Authors:  Ayalew Tefferi; Hagop Kantarjian; S Vincent Rajkumar; Lawrence H Baker; Jan L Abkowitz; John W Adamson; Ranjana Hira Advani; James Allison; Karen H Antman; Robert C Bast; John M Bennett; Edward J Benz; Nancy Berliner; Joseph Bertino; Ravi Bhatia; Smita Bhatia; Deepa Bhojwani; Charles D Blanke; Clara D Bloomfield; Linda Bosserman; Hal E Broxmeyer; John C Byrd; Fernando Cabanillas; George Peter Canellos; Bruce A Chabner; Asher Chanan-Khan; Bruce Cheson; Bayard Clarkson; Susan L Cohn; Gerardo Colon-Otero; Jorge Cortes; Steven Coutre; Massimo Cristofanilli; Walter J Curran; George Q Daley; Daniel J DeAngelo; H Joachim Deeg; Lawrence H Einhorn; Harry P Erba; Francisco J Esteva; Elihu Estey; Isaiah J Fidler; James Foran; Stephen Forman; Emil Freireich; Charles Fuchs; James N George; Morie A Gertz; Sergio Giralt; Harvey Golomb; Peter Greenberg; Jordan Gutterman; Robert I Handin; Samuel Hellman; Paulo Marcelo Hoff; Ronald Hoffman; Waun Ki Hong; Mary Horowitz; Gabriel N Hortobagyi; Clifford Hudis; Jean Pierre Issa; Bruce Evan Johnson; Philip W Kantoff; Kenneth Kaushansky; David Khayat; Fadlo R Khuri; Thomas J Kipps; Margaret Kripke; Robert A Kyle; Richard A Larson; Theodore S Lawrence; Ross Levine; Michael P Link; Scott M Lippman; Sagar Lonial; Gary H Lyman; Maurie Markman; John Mendelsohn; Neal J Meropol; Yoav Messinger; Therese M Mulvey; Susan O'Brien; Roman Perez-Soler; Raphael Pollock; Josef Prchal; Oliver Press; Jerald Radich; Kanti Rai; Saul A Rosenberg; Jacob M Rowe; Hope Rugo; Carolyn D Runowicz; Brenda M Sandmaier; Alan Saven; Andrew I Schafer; Charles Schiffer; Mikkael A Sekeres; Richard T Silver; Lillian L Siu; David P Steensma; F Marc Stewart; Wendy Stock; Richard Stone; Rainer Storb; Louise C Strong; Martin S Tallman; Michael Thompson; Naoto T Ueno; Richard A Van Etten; Julie M Vose; Peter H Wiernik; Eric P Winer; Anas Younes; Andrew D Zelenetz; Charles A LeMaistre
Journal:  Mayo Clin Proc       Date:  2015-07-23       Impact factor: 7.616

Review 8.  Improving adherence to oral cancer therapy in clinical practice.

Authors:  Debbie A McCue; Lisa K Lohr; Amy M Pick
Journal:  Pharmacotherapy       Date:  2014-05       Impact factor: 4.705

9.  Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the children's oncology group.

Authors:  Smita Bhatia; Wendy Landier; Muyun Shangguan; Lindsey Hageman; Alexandra N Schaible; Andrea R Carter; Cara L Hanby; Wendy Leisenring; Yutaka Yasui; Nancy M Kornegay; Leo Mascarenhas; A Kim Ritchey; Jacqueline N Casillas; David S Dickens; Jane Meza; William L Carroll; Mary V Relling; F Lennie Wong
Journal:  J Clin Oncol       Date:  2012-05-07       Impact factor: 44.544

Review 10.  Oral chemotherapy: rationale and future directions.

Authors:  M D DeMario; M J Ratain
Journal:  J Clin Oncol       Date:  1998-07       Impact factor: 44.544

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  3 in total

Review 1.  Economic Impact of Oral Therapies for Chronic Lymphocytic Leukemia-the Burden of Novelty.

Authors:  Talal Hilal; Jeffrey A Betcher; Jose F Leis
Journal:  Curr Hematol Malig Rep       Date:  2018-08       Impact factor: 3.952

2.  Adherence to tyrosine kinase inhibitors among Medicare Part D beneficiaries with chronic myeloid leukemia.

Authors:  Chan Shen; Bo Zhao; Lei Liu; Ya-Chen Tina Shih
Journal:  Cancer       Date:  2017-10-04       Impact factor: 6.860

3.  Adherence to Oral Anticancer Medications: Evolving Interprofessional Roles and Pharmacist Workforce Considerations.

Authors:  Gennaro A Paolella; Andrew D Boyd; Scott M Wirth; Sandra Cuellar; Neeta K Venepalli; Stephanie Y Crawford
Journal:  Pharmacy (Basel)       Date:  2018-03-08
  3 in total

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