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Literature DB >> 27082135

Engineering human cells and tissues through pluripotent stem cells.

Abstract

The utility of human pluripotent stem cells (hPSCs) depends on their ability to produce functional cells and tissues of the body. Two strategies have been developed: directed differentiation of enriched populations of cells that match a regional and functional profile and spontaneous generation of three-dimensional organoids that resemble tissues in the body. Genomic editing of hPSCs and their differentiated cells broadens the use of the hPSC paradigm in studying human cellular function and disease as well as developing therapeutics.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2016 PMID： 27082135 PMCID： PMC4975619 DOI： 10.1016/j.copbio.2016.03.010

Source DB: PubMed Journal: Curr Opin Biotechnol ISSN： 0958-1669 Impact factor: 9.740

52 in total

1. Self-formation of optic cups and storable stratified neural retina from human ESCs.

Authors: Tokushige Nakano; Satoshi Ando; Nozomu Takata; Masako Kawada; Keiko Muguruma; Kiyotoshi Sekiguchi; Koichi Saito; Shigenobu Yonemura; Mototsugu Eiraku; Yoshiki Sasai
Journal: Cell Stem Cell Date: 2012-06-14 Impact factor: 24.633

2. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice.

Authors: Lixiang Ma; Baoyang Hu; Yan Liu; Scott Christopher Vermilyea; Huisheng Liu; Lu Gao; Yan Sun; Xiaoqing Zhang; Su-Chun Zhang
Journal: Cell Stem Cell Date: 2012-03-15 Impact factor: 24.633

Review 3. Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy.

Authors: C Papayannakos; R Daniel
Journal: Gene Ther Date: 2012-11-22 Impact factor: 5.250

4. Efficient generation of retinal progenitor cells from human embryonic stem cells.

Authors: Deepak A Lamba; Mike O Karl; Carol B Ware; Thomas A Reh
Journal: Proc Natl Acad Sci U S A Date: 2006-08-14 Impact factor: 11.205

5. Generation of serotonin neurons from human pluripotent stem cells.

Authors: Jianfeng Lu; Xuefei Zhong; Huisheng Liu; Ling Hao; Cindy Tzu-Ling Huang; Mohammad Amin Sherafat; Jeffrey Jones; Melvin Ayala; Lingjun Li; Su-Chun Zhang
Journal: Nat Biotechnol Date: 2015-12-14 Impact factor: 54.908

6. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity.

Authors: A Hemmati-Brivanlou; O G Kelly; D A Melton
Journal: Cell Date: 1994-04-22 Impact factor: 41.582

Engineering human cells and tissues through pluripotent stem cells.

1. Self-formation of optic cups and storable stratified neural retina from human ESCs.

2. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice.

Review 3. Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy.

4. Efficient generation of retinal progenitor cells from human embryonic stem cells.

5. Generation of serotonin neurons from human pluripotent stem cells.

6. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity.

7. Embryonic stem cell lines derived from human blastocysts.

8. Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells.

9. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.

10. Structural mechanism of cytosolic DNA sensing by cGAS.

1. Using Induced Pluripotent Stem Cells to Investigate Complex Genetic Psychiatric Disorders.

2. Dynamic Variations in Genetic Integrity Accompany Changes in Cell Fate.

Review 3. Reprogramming cell fate with artificial transcription factors.

Review 4. Patient-Specific Organoid and Organ-on-a-Chip: 3D Cell-Culture Meets 3D Printing and Numerical Simulation.

Review 5. Advancing cardiovascular tissue engineering.

6. Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease.

Review 7. Methods and applications of CRISPR/Cas system for genome editing in stem cells.