Literature DB >> 2708156

The combined effect of cisplatin and furosemide on hearing function in guinea pigs.

G Laurell1, B Engström.   

Abstract

The effect of the combined administration of cisplatin and furosemide on the electrophysiological hearing thresholds and endocochlear DC potential (EP) was studied in guinea pigs. A lack of interaction was found in animals given repeated intraperitoneal injections of a low dose of cisplatin with a pharmacological dose of furosemide. An ototoxic interaction occurred when a moderately high dose of cisplatin was administered intravenously at a time when the strial function was most affected by a very high dose of furosemide. The interaction was seen both as a decreased EP and a pronounced shift of auditory thresholds. It is concluded that the stria vascularis plays a role in the ototoxic mechanism of cisplatin.

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Year:  1989        PMID： 2708156     DOI： 10.1016/0378-5955(89)90124-x

Source DB:  PubMed          Journal:  Hear Res        ISSN： 0378-5955            Impact factor:   3.208


  10 in total

1.  Inhibition of adenylate-cyclase-coupled G protein complex by ototoxic diuretics and cis-platinum in the inner ear of the guinea pig.

Authors:  T Koch; B Gloddek
Journal:  Eur Arch Otorhinolaryngol       Date:  1991       Impact factor: 2.503

Review 2.  An integrated view of cisplatin-induced nephrotoxicity and ototoxicity.

Authors:  Takatoshi Karasawa; Peter S Steyger
Journal:  Toxicol Lett       Date:  2015-06-20       Impact factor: 4.372

3.  Acute hyperpolarization and elongation of cochlear outer hair cells on superfusion with cis-platinum.

Authors:  A Ernst; H P Zenner
Journal:  Eur Arch Otorhinolaryngol       Date:  1995       Impact factor: 2.503

4.  Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice.

Authors:  Yongqi Li; Dalian Ding; Haiyan Jiang; Yong Fu; Richard Salvi
Journal:  Neurotox Res       Date:  2011-04-01       Impact factor: 3.911

5.  Effect of cisplatin on the negative charge barrier in strial vessels of the guinea pig. A transmission electron microscopic study using polyethyleneimine molecules.

Authors:  M Suzuki; K Kaga
Journal:  Eur Arch Otorhinolaryngol       Date:  1996       Impact factor: 2.503

Review 6.  Drug-induced ototoxicity. Pathogenesis and prevention.

Authors:  M Y Huang; J Schacht
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Nov-Dec

7.  Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in the Neuromast Hair Cells.

Authors:  Jonathon W Vargo; Steven N Walker; Suhasini R Gopal; Aditi R Deshmukh; Brian M McDermott; Kumar N Alagramam; Ruben Stepanyan
Journal:  Front Cell Neurosci       Date:  2017-12-12       Impact factor: 5.505

8.  Ototoxicity and Platinum Uptake Following Cyclic Administration of Platinum-Based Chemotherapeutic Agents.

Authors:  Benjamin K Gersten; Tracy S Fitzgerald; Katharine A Fernandez; Lisa L Cunningham
Journal:  J Assoc Res Otolaryngol       Date:  2020-06-24

9.  The Acute Effects of Furosemide on Na-K-Cl Cotransporter-1, Fetuin-A and Pigment Epithelium-Derived Factor in the Guinea Pig Cochlea.

Authors:  Jesper Edvardsson Rasmussen; Patrik Lundström; Per Olof Eriksson; Helge Rask-Andersen; Wei Liu; Göran Laurell
Journal:  Front Mol Neurosci       Date:  2022-03-22       Impact factor: 5.639

Review 10.  Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity.

Authors:  Debashree Mukherjea; Asmita Dhukhwa; Amit Sapra; Priyanka Bhandari; Katlyn Woolford; Jacob Franke; Vickram Ramkumar; Leonard Rybak
Journal:  Expert Opin Drug Metab Toxicol       Date:  2020-09-29       Impact factor: 4.481
  10 in total

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