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Literature DB >> 27076625

Epithelial-Mesenchymal Transition and Immune Evasion during Lung Cancer Progression: The Chicken or the Egg?

Abstract

Epithelial-mesenchymal transition (EMT) is a complex process involved in metastasis. Immune evasion is required for tumor progression and is characterized by an ineffective antitumor immune response and upregulation of immune-suppressive signals. The coexistence of EMT and adaptive immune evasion opens the possibility of a mechanistic link between these processes. Clin Cancer Res; 22(14); 3422-4. ©2016 AACRSee related article by Lou et al., p. 3630. ©2016 American Association for Cancer Research.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2016 PMID： 27076625 PMCID： PMC4947415 DOI： 10.1158/1078-0432.CCR-16-0336

Source DB: PubMed Journal: Clin Cancer Res ISSN： 1078-0432 Impact factor: 12.531

14 in total

1. Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma.

Authors: Yanyan Lou; Lixia Diao; Edwin Roger Parra Cuentas; Warren L Denning; Limo Chen; You Hong Fan; Lauren A Byers; Jing Wang; Vassiliki A Papadimitrakopoulou; Carmen Behrens; Jaime Canales Rodriguez; Patrick Hwu; Ignacio I Wistuba; John V Heymach; Don L Gibbons
Journal: Clin Cancer Res Date: 2016-02-05 Impact factor: 12.531

2. Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.

Authors: Stefani Spranger; Riyue Bao; Thomas F Gajewski
Journal: Nature Date: 2015-05-11 Impact factor: 49.962

3. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.

Authors: Roy S Herbst; Jean-Charles Soria; Marcin Kowanetz; Gregg D Fine; Omid Hamid; Michael S Gordon; Jeffery A Sosman; David F McDermott; John D Powderly; Scott N Gettinger; Holbrook E K Kohrt; Leora Horn; Donald P Lawrence; Sandra Rost; Maya Leabman; Yuanyuan Xiao; Ahmad Mokatrin; Hartmut Koeppen; Priti S Hegde; Ira Mellman; Daniel S Chen; F Stephen Hodi
Journal: Nature Date: 2014-11-27 Impact factor: 49.962

4. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.

Authors: Naiyer A Rizvi; Matthew D Hellmann; Alexandra Snyder; Pia Kvistborg; Vladimir Makarov; Jonathan J Havel; William Lee; Jianda Yuan; Phillip Wong; Teresa S Ho; Martin L Miller; Natasha Rekhtman; Andre L Moreira; Fawzia Ibrahim; Cameron Bruggeman; Billel Gasmi; Roberta Zappasodi; Yuka Maeda; Chris Sander; Edward B Garon; Taha Merghoub; Jedd D Wolchok; Ton N Schumacher; Timothy A Chan
Journal: Science Date: 2015-03-12 Impact factor: 47.728

Review 5. Multilayer control of the EMT master regulators.

Authors: H Zheng; Y Kang
Journal: Oncogene Date: 2013-04-22 Impact factor: 9.867

Review 6. Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment?

Authors: M Pietilä; J Ivaska; S A Mani
Journal: Cancer Lett Date: 2016-01-11 Impact factor: 8.679

7. M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway.

Authors: Chao-Ying Liu; Juan-Ying Xu; Xiao-Yan Shi; Wei Huang; Ting-Yan Ruan; Ping Xie; Jun-Li Ding
Journal: Lab Invest Date: 2013-06-10 Impact factor: 5.662

8. Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells.

Authors: Chie Kudo-Saito; Hiromi Shirako; Tadashi Takeuchi; Yutaka Kawakami
Journal: Cancer Cell Date: 2009-03-03 Impact factor: 31.743

9. PD-1 blockade induces responses by inhibiting adaptive immune resistance.

Authors: Paul C Tumeh; Christina L Harview; Jennifer H Yearley; I Peter Shintaku; Emma J M Taylor; Lidia Robert; Bartosz Chmielowski; Marko Spasic; Gina Henry; Voicu Ciobanu; Alisha N West; Manuel Carmona; Christine Kivork; Elizabeth Seja; Grace Cherry; Antonio J Gutierrez; Tristan R Grogan; Christine Mateus; Gorana Tomasic; John A Glaspy; Ryan O Emerson; Harlan Robins; Robert H Pierce; David A Elashoff; Caroline Robert; Antoni Ribas
Journal: Nature Date: 2014-11-27 Impact factor: 49.962

10. Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: significance in claudin-low breast cancer cells.

Authors: Abdullah Alsuliman; Dilek Colak; Olfat Al-Harazi; Hanaa Fitwi; Asma Tulbah; Taher Al-Tweigeri; Monther Al-Alwan; Hazem Ghebeh
Journal: Mol Cancer Date: 2015-08-07 Impact factor: 27.401

21 in total

1. PD-L1 and epithelial-mesenchymal transition in circulating tumor cells from non-small cell lung cancer patients: A molecular shield to evade immune system?

Authors: Cristina Raimondi; Guido Carpino; Chiara Nicolazzo; Angela Gradilone; Walter Gianni; Alain Gelibter; Eugenio Gaudio; Enrico Cortesi; Paola Gazzaniga
Journal: Oncoimmunology Date: 2017-04-20 Impact factor: 8.110

2. Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment.

Authors: Florence Gazeau; Emmanuel Donnadieu; Alba Nicolas-Boluda; Javier Vaquero; Lene Vimeux; Thomas Guilbert; Sarah Barrin; Chahrazade Kantari-Mimoun; Matteo Ponzo; Gilles Renault; Piotr Deptula; Katarzyna Pogoda; Robert Bucki; Ilaria Cascone; José Courty; Laura Fouassier
Journal: Elife Date: 2021-06-09 Impact factor: 8.140

3. Murine Mammary Carcinoma Induces Chronic Systemic Inflammation and Immunosuppression in BALB/c Mice.

Authors: Dasha Fuentes; Alejandro Cabezas-Cruz; Circe Mesa; Tania Carmenate; Darel Martínez; Anet Valdés-Zayas; Enrique Montero; Rolando Pérez
Journal: J Breast Cancer Date: 2022-04-26 Impact factor: 2.922

4. AKIP1 promoted epithelial-mesenchymal transition of non-small-cell lung cancer via transactivating ZEB1.

Authors: Xiaobin Guo; Limin Zhao; Dongjun Cheng; Qing Mu; Hongyan Kuang; Keqing Feng
Journal: Am J Cancer Res Date: 2017-11-01 Impact factor: 6.166

5. Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis.

Authors: Ila Datar; Miguel F Sanmamed; Jun Wang; Brian S Henick; Jungmin Choi; Ti Badri; Weilai Dong; Nikita Mani; Maria Toki; Luis D Mejías; Maria D Lozano; Jose Luis Perez-Gracia; Vamsidhar Velcheti; Matthew D Hellmann; Justin F Gainor; Kristen McEachern; David Jenkins; Konstantinos Syrigos; Katerina Politi; Scott Gettinger; David L Rimm; Roy S Herbst; Ignacio Melero; Lieping Chen; Kurt A Schalper
Journal: Clin Cancer Res Date: 2019-05-03 Impact factor: 12.531

Review 6. Emerging role of tumor cell plasticity in modifying therapeutic response.

Authors: Siyuan Qin; Jingwen Jiang; Yi Lu; Edouard C Nice; Canhua Huang; Jian Zhang; Weifeng He
Journal: Signal Transduct Target Ther Date: 2020-10-07

7. Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy.

Authors: Robert M Samstein; Chirag Krishna; Xiaoxiao Ma; Xin Pei; Ken-Wing Lee; Vladimir Makarov; Fengshen Kuo; Jonathan Chung; Raghvendra M Srivastava; Tanaya A Purohit; Douglas R Hoen; Rajarsi Mandal; Jeremy Setton; Wei Wu; Rachna Shah; Besnik Qeriqi; Qing Chang; Sviatoslav Kendall; Lior Braunstein; Britta Weigelt; Pedro Blecua Carrillo Albornoz; Luc G T Morris; Diana L Mandelker; Jorge S Reis-Filho; Elisa de Stanchina; Simon N Powell; Timothy A Chan; Nadeem Riaz
Journal: Nat Cancer Date: 2020-11-16