Literature DB >> 2707640

Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat.

I Tsukamoto1, S Kojo.   

Abstract

The increase in activities of hepatic thymidylate synthetase (EC 2.1.1.45) and thymidine kinase (EC 2.7.1.21), which catalyse the formation of thymidylate through the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which were given glucocorticoids (hydrocortisone and dexamethasone) or indomethacin. These drugs also prevented the augment of hepatic DNA content in 24 h regenerating liver.

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Year:  1989        PMID： 2707640      PMCID： PMC1378464          DOI： 10.1136/gut.30.3.387

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  22 in total

1.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

2.  Inhibition of DNA synthesis in regenerating rat liver hy hydrocortisone.

Authors:  K H Raab; T E Webb
Journal:  Experientia       Date:  1969-12-15

Review 3.  Gene expression during the mammalian cell cycle.

Authors:  D T Denhardt; D R Edwards; C L Parfett
Journal:  Biochim Biophys Acta       Date:  1986-10-28

4.  Liver regeneration after carbon tetrachloride intoxication in the rat.

Authors:  R Nakata; I Tsukamoto; M Miyoshi; S Kojo
Journal:  Biochem Pharmacol       Date:  1985-02-15       Impact factor: 5.858

5.  Alpha-adrenergic regulation of the activity of thymidylate synthetase and thymidine kinase during liver regeneration after partial hepatectomy.

Authors:  R Nakata; I Tsukamoto; M Nanme; S Makino; M Miyoshi; S Kojo
Journal:  Eur J Pharmacol       Date:  1985-08-27       Impact factor: 4.432

6.  Suppression of liver cell proliferation by glucocorticoid hormone: a comparison of normally growing and regenerating tissue in the immature rat.

Authors:  T J Castellano; R L Schiffman; M C Jacob; J N Loeb
Journal:  Endocrinology       Date:  1978-04       Impact factor: 4.736

7.  A connection between the production of prostaglandins during liver regeneration and the DNA synthetic response.

Authors:  J P MacManus; B M Braceland
Journal:  Prostaglandins       Date:  1976-04

8.  Effect of calcium channel blockers and trifluoperazine on rat liver regeneration.

Authors:  I Tsukamoto; S Kojo
Journal:  Eur J Pharmacol       Date:  1987-12-01       Impact factor: 4.432

9.  Reversal of ethanol and indomethacin-induced suppression of hepatic DNA synthesis by 16,16-dimethyl prostaglandin E2.

Authors:  G E McNeil; T S Chen; C M Leevy
Journal:  Hepatology       Date:  1985 Jan-Feb       Impact factor: 17.425

10.  Effects of cortisone on regenerating rat liver.

Authors:  S L EINHORN; E HIRSCHBERG; A GELLHORN
Journal:  J Gen Physiol       Date:  1954-03       Impact factor: 4.086
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  6 in total

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5.  The Role of Hepatic Vagal Tone in Ozone-Induced Metabolic Dysfunction in the Liver.

Authors:  Catherine H Colonna; Andres R Henriquez; John S House; Alison A Motsinger-Reif; Devin I Alewel; Anna Fisher; Hongzu Ren; Samantha J Snow; Mette C Schladweiler; Desinia B Miller; Colette N Miller; Prasada Rao S Kodavanti; Urmila P Kodavanti
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6.  Silencing of maternal hepatic glucocorticoid receptor is essential for normal fetal development in mice.

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  6 in total

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