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Literature DB >> 270739

Polypeptide hormone binding sites in vivo: initial localization of 125I-labeled insulin to hepatocyte plasmalemma as visualized by electron microscope radioautography.

J J Bergeron, G Levine, R Sikstrom, D O'Shaughnessy, B Kopriwa, N J Nadler, B I Posner.

Abstract

The rationale of the specific-binding assay was applied to the detection of the liver insulin receptor in vivo. Quantitative electron microscope radioautography indicated that, 3 min after an intraportal injection, 125I-insulin was exclusively located to the hepatocyte plasmalemma.

Entities: Chemical Disease Gene

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Year: 1977 PMID： 270739 PMCID： PMC432096 DOI： 10.1073/pnas.74.11.5051

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

26 in total

1. Immunoassay of endogenous plasma insulin in man.

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2. Insulin receptors in human and animal placental tissue.

Authors: B I Posner
Journal: Diabetes Date: 1974-03 Impact factor: 9.461

3. An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells.

Authors: E Wisse
Journal: J Ultrastruct Res Date: 1972-03

4. ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase.

Authors: R J Lefkowitz; J Roth; W Pricer; I Pastan
Journal: Proc Natl Acad Sci U S A Date: 1970-03 Impact factor: 11.205

5. A reliable, standardized method for ultrastructural electron microscopic radioautography.

Authors: B M Kopriwa
Journal: Histochemie Date: 1973-10-03

6. Correlation of grain counts with radioactivity (125I and tritium) in autoradiography.

Authors: G L Ada; J H Humphrey; B A Askonas; H O McDevitt; G J Nossal
Journal: Exp Cell Res Date: 1966-03 Impact factor: 3.905

7. Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity.

Authors: P Freychet; J Roth; D M Neville
Journal: Proc Natl Acad Sci U S A Date: 1971-08 Impact factor: 11.205

8. A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY.

Authors: J H VENABLE; R COGGESHALL
Journal: J Cell Biol Date: 1965-05 Impact factor: 10.539

9. Staining of tissue sections for electron microscopy with heavy metals.

Authors: M L WATSON
Journal: J Biophys Biochem Cytol Date: 1958-07-25

10. Resolution in electron microscope autoradiography. III. Iodine-125, the effect of heavy metal staining, and a reassessment of critical parameters.

Authors: M M Salpeter; H C Fertuck; E E Salpeter
Journal: J Cell Biol Date: 1977-01 Impact factor: 10.539

16 in total

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Authors: H Sato; T Terasaki; H Mizuguchi; K Okumura; A Tsuji
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2. Intracellular pathways of receptor-bound GnRH agonist in pituitary gonadotropes.

Authors: E Hazum; Y Koch; M Liscovitch; A Amsterdam
Journal: Cell Tissue Res Date: 1985 Impact factor: 5.249

3. Uptake and subcellular processing of 59Fe-125I-labelled transferrin by rat liver.

Authors: E H Morgan; G D Smith; T J Peters
Journal: Biochem J Date: 1986-07-01 Impact factor: 3.857

4. Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

Authors: J L Carpentier; P Gorden; P Freychet; A Le Cam; L Orci
Journal: J Clin Invest Date: 1979-06 Impact factor: 14.808

5. Intracellular localization of 125I-labeled insulin in hepatocytes from intact rat liver.

Authors: J L Carpentier; P Gorden; P Barazzone; P Freychet; A Le Cam; L Orci
Journal: Proc Natl Acad Sci U S A Date: 1979-06 Impact factor: 11.205

6. Characterization of lactogen binding sites in choroid plexus.

Authors: B I Posner; M van Houten; B Patel; R J Walsh
Journal: Exp Brain Res Date: 1983 Impact factor: 1.972

7. Binding, internalization, and lysosomal association of 125I-glucagon in isolated rat hepatocytes. A quantitative electron microscope autoradiographic study.

Authors: P Barazzone; P Gorden; J L Carpentier; L Orci; P Freychet; B Canivet
Journal: J Clin Invest Date: 1980-11 Impact factor: 14.808