Michael Monfett1, Julian Harrison1, Kwadwo Boachie-Adjei1, Gregory Lutz2. 1. Department of Physiatry, Hospital for Special Surgery, 429 E 75th Street, 3rd Floor, New York, NY, 10021, USA. 2. Department of Physiatry, Hospital for Special Surgery, 429 E 75th Street, 3rd Floor, New York, NY, 10021, USA. lutzg@hss.edu.
Abstract
PURPOSE: The aim of this article is to provide an overview of clinical and translational research on intradiscal platelet-rich plasma (PRP) as a minimally invasive treatment for discogenic low back pain. METHODS: A literature review of in vitro, in vivo, and clinical studies was performed. RESULTS: There is strong in vitro evidence that supports the use of intradiscal PRP for discogenic low back pain. There are also promising findings in select preclinical animal studies. A clinical study of 29 participants who underwent intradiscal PRP injections for discogenic low back pain found statistically and clinically significant improvements in pain and function through two years of follow-up. CONCLUSIONS: Intradiscal PRP is a safe and a possibly effective treatment for discogenic low back pain. Future studies are warranted to determine the best candidates for this treatment, what the optimal injectate is and what relationships exist between patient-reported outcomes and radiological findings.
PURPOSE: The aim of this article is to provide an overview of clinical and translational research on intradiscal platelet-rich plasma (PRP) as a minimally invasive treatment for discogenic low back pain. METHODS: A literature review of in vitro, in vivo, and clinical studies was performed. RESULTS: There is strong in vitro evidence that supports the use of intradiscal PRP for discogenic low back pain. There are also promising findings in select preclinical animal studies. A clinical study of 29 participants who underwent intradiscal PRP injections for discogenic low back pain found statistically and clinically significant improvements in pain and function through two years of follow-up. CONCLUSIONS: Intradiscal PRP is a safe and a possibly effective treatment for discogenic low back pain. Future studies are warranted to determine the best candidates for this treatment, what the optimal injectate is and what relationships exist between patient-reported outcomes and radiological findings.
Authors: Svenja Illien-Jünger; Young Lu; Devina Purmessur; Jillian E Mayer; Benjamin A Walter; Peter J Roughley; Sheeraz A Qureshi; Andrew C Hecht; James C Iatridis Journal: Spine J Date: 2014-04-24 Impact factor: 4.166
Authors: Gregory B Gullung; James W Woodall; Michelle A Tucci; Judy James; David A Black; Robert A McGuire Journal: Evid Based Spine Care J Date: 2011-11
Authors: Jennifer Cheng; Kristen A Santiago; Joseph T Nguyen; Jennifer L Solomon; Gregory E Lutz Journal: Regen Med Date: 2019-08-29 Impact factor: 3.806
Authors: Abbey A Thorpe; Frances C Bach; Marianna A Tryfonidou; Christine L Le Maitre; Fackson Mwale; Ashish D Diwan; Keita Ito Journal: JOR Spine Date: 2018-08-02