Literature DB >> 29732431

Platelet-rich plasma injections: an emerging therapy for chronic discogenic low back pain.

Suja Mohammed1, James Yu1,2.   

Abstract

Autologous platelet-rich plasma (PRP) injections have been investigated in recent years as an emerging therapy for various musculoskeletal conditions, including lumbar degenerative disc disease. Although PRP has received increasing attention from medical science experts, comprehensive clinical reports of its efficacy are limited to those treating knee osteoarthritis and epicondylitis. Use of PRP is gaining popularity in the area of degenerative disc disease, but there is a clear need for reliable clinical evidence of its applications and effectiveness. In this article, we review the current literature on PRP therapy and its potential use in the treatment of chronic discogenic low back pain, with a focus on evidence from clinical trials.

Entities:  

Keywords:  Platelet-rich plasma (PRP); chronic back pain; disc degeneration; discogenic

Year:  2018        PMID: 29732431      PMCID: PMC5911760          DOI: 10.21037/jss.2018.03.04

Source DB:  PubMed          Journal:  J Spine Surg        ISSN: 2414-4630


  44 in total

Review 1.  Antimicrobial properties of platelet-rich preparations. A systematic review of the current pre-clinical evidence.

Authors:  Massimo Del Fabbro; Monica Bortolin; Silvio Taschieri; Caterina Ceci; Roberto L Weinstein
Journal:  Platelets       Date:  2016-01-14       Impact factor: 3.862

2.  Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture.

Authors:  Eduardo Anitua; Isabel Andía; Mikel Sanchez; Juan Azofra; M del Mar Zalduendo; María de la Fuente; Paquita Nurden; Alan T Nurden
Journal:  J Orthop Res       Date:  2005-03       Impact factor: 3.494

3.  Increased Nuclear T2 Signal Intensity and Improved Function and Pain in a Patient One Year After an Intradiscal Platelet-Rich Plasma Injection.

Authors:  Gregory E Lutz
Journal:  Pain Med       Date:  2017-06-01       Impact factor: 3.750

Review 4.  Emerging technologies for molecular therapy for intervertebral disk degeneration.

Authors:  Won C Bae; Koichi Masuda
Journal:  Orthop Clin North Am       Date:  2011-10       Impact factor: 2.472

Review 5.  Systematic reviews and meta-analyses in spine surgery, neurosurgery and orthopedics: guidelines for the surgeon scientist.

Authors:  Kevin Phan; Ralph J Mobbs
Journal:  J Spine Surg       Date:  2015-12

Review 6.  Pathophysiology of lumbar disc degeneration: a review of the literature.

Authors:  Michael D Martin; Christopher M Boxell; David G Malone
Journal:  Neurosurg Focus       Date:  2002-08-15       Impact factor: 4.047

Review 7.  Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review.

Authors:  Y Zhu; M Yuan; H Y Meng; A Y Wang; Q Y Guo; Y Wang; J Peng
Journal:  Osteoarthritis Cartilage       Date:  2013-08-07       Impact factor: 6.576

8.  Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial.

Authors:  Koji Akeda; Kohshi Ohishi; Koichi Masuda; Won C Bae; Norihiko Takegami; Junichi Yamada; Tomoki Nakamura; Toshihiko Sakakibara; Yuichi Kasai; Akihiro Sudo
Journal:  Asian Spine J       Date:  2017-06-15

Review 9.  Update on the pathophysiology of degenerative disc disease and new developments in treatment strategies.

Authors:  Adam H Hsieh; S Tim Yoon
Journal:  Open Access J Sports Med       Date:  2010-10-14

10.  Lumbar degenerative disc disease: current and future concepts of diagnosis and management.

Authors:  Fadi Taher; David Essig; Darren R Lebl; Alexander P Hughes; Andrew A Sama; Frank P Cammisa; Federico P Girardi
Journal:  Adv Orthop       Date:  2012-04-02
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  10 in total

1.  Treatment of symptomatic degenerative intervertebral discs with autologous platelet-rich plasma: follow-up at 5-9 years.

Authors:  Jennifer Cheng; Kristen A Santiago; Joseph T Nguyen; Jennifer L Solomon; Gregory E Lutz
Journal:  Regen Med       Date:  2019-08-29       Impact factor: 3.806

Review 2.  Stem Cell Therapies for Treatment of Discogenic Low Back Pain: a Comprehensive Review.

Authors:  Ivan Urits; Alexander Capuco; Medha Sharma; Alan D Kaye; Omar Viswanath; Elyse M Cornett; Vwaire Orhurhu
Journal:  Curr Pain Headache Rep       Date:  2019-07-29

3.  The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review.

Authors:  Aung Chan Thu
Journal:  J Yeungnam Med Sci       Date:  2022-06-08

4.  Complementary and Alternative Modalities (CAM) for pain management in musculoskeletal diseases (MSDs).

Authors:  Debesh Bhoi; Dhruv Jain; Rakesh Garg; Karthikeyan P Iyengar; Wasimul Hoda; Raju Vaishya; Vijay Kumar Jain
Journal:  J Clin Orthop Trauma       Date:  2021-04-29

Review 5.  The "Janus Face" of Platelets in Cancer.

Authors:  Maria Valeria Catani; Isabella Savini; Valentina Tullio; Valeria Gasperi
Journal:  Int J Mol Sci       Date:  2020-01-25       Impact factor: 5.923

Review 6.  Effect of Platelet-Rich Plasma on Intervertebral Disc Degeneration In Vivo and In Vitro: A Critical Review.

Authors:  Yvang Chang; Ming Yang; Song Ke; Yu Zhang; Gang Xu; Zhonghai Li
Journal:  Oxid Med Cell Longev       Date:  2020-11-21       Impact factor: 6.543

7.  Does the Intradiscal Injection of Platelet Rich Plasma Have Any Beneficial Role in the Management of Lumbar Disc Disease?

Authors:  Sathish Muthu; Madhan Jeyaraman; Girinivasan Chellamuthu; Naveen Jeyaraman; Rashmi Jain; Manish Khanna
Journal:  Global Spine J       Date:  2021-04-12

8.  Ultrasound-Guided Lumbar Intradiscal Injection for Discogenic Pain: Technical Innovation and Presentation of Two Cases.

Authors:  Tsung-Ju Wu; Chen-Yu Hung; Chih-Wei Lee; Stanley Lam; Thomas B Clark; Ke-Vin Chang
Journal:  J Pain Res       Date:  2020-05-19       Impact factor: 3.133

Review 9.  Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies.

Authors:  Wen-Cheng Lo; Lung-Wen Tsai; Yi-Shan Yang; Ryan Wing Yuk Chan
Journal:  Int J Mol Sci       Date:  2021-03-31       Impact factor: 5.923

10.  Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study.

Authors:  Zhen Xu; Shaoling Wu; Xiao Li; Cuicui Liu; Shengnuo Fan; Chao Ma
Journal:  Neural Plast       Date:  2021-05-27       Impact factor: 3.599

  10 in total

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