BACKGROUND/ OBJECTIVES: The n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been associated with lower risk of cardiovascular disease (CVD), but little is known about their association with natriuretic peptides (NPs), a marker for CVD risk. The aim of this study was to investigate the association of serum n-3 and n-6 PUFAs with NPs. SUBJECTS/ METHODS: A cross-sectional analysis of the association between serum n-3 and n-6 PUFAs with plasma N-terminal atrial (NT-proANP) and brain (NT-proBNP) NPs in a population-based sample of 985 men aged 46-65 years from Eastern Finland. RESULTS: After adjustment for age and examination year, only serum n-6 PUFA arachidonic acid (ARA) was inversely associated with NT-proANP (P-trend across quartiles=0.02), but further adjustments for conventional risk factors (body mass index, smoking, alcohol intake, systolic blood pressure, low-density lipoprotein cholesterol and history of CVD) attenuated the association (P-trend=0.10). The associations with the other PUFAs were not statistically significant. Among the PUFAs, only serum n-3 PUFA docosapentaenoic acid (DPA; P-trend=0.03) and ARA (P-trend=0.02) had inverse associations with NT-proBNP after adjustment for age and examination years. The associations were again attenuated after further adjustments but remained statistically significant for DPA (P-trend=0.05). Our results also suggested that the inverse associations may be more evident among those using beta-blockers. CONCLUSIONS: Our study suggests little overall impact of serum n-3 or n-6 PUFAs on plasma NPs.
BACKGROUND/ OBJECTIVES: The n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been associated with lower risk of cardiovascular disease (CVD), but little is known about their association with natriuretic peptides (NPs), a marker for CVD risk. The aim of this study was to investigate the association of serum n-3 and n-6 PUFAs with NPs. SUBJECTS/ METHODS: A cross-sectional analysis of the association between serum n-3 and n-6 PUFAs with plasma N-terminal atrial (NT-proANP) and brain (NT-proBNP) NPs in a population-based sample of 985 men aged 46-65 years from Eastern Finland. RESULTS: After adjustment for age and examination year, only serum n-6 PUFA arachidonic acid (ARA) was inversely associated with NT-proANP (P-trend across quartiles=0.02), but further adjustments for conventional risk factors (body mass index, smoking, alcohol intake, systolic blood pressure, low-density lipoprotein cholesterol and history of CVD) attenuated the association (P-trend=0.10). The associations with the other PUFAs were not statistically significant. Among the PUFAs, only serum n-3 PUFA docosapentaenoic acid (DPA; P-trend=0.03) and ARA (P-trend=0.02) had inverse associations with NT-proBNP after adjustment for age and examination years. The associations were again attenuated after further adjustments but remained statistically significant for DPA (P-trend=0.05). Our results also suggested that the inverse associations may be more evident among those using beta-blockers. CONCLUSIONS: Our study suggests little overall impact of serum n-3 or n-6 PUFAs on plasma NPs.
Authors: Jyrki K Virtanen; Jaakko Mursu; Tomi-Pekka Tuomainen; Sari Voutilainen Journal: Arterioscler Thromb Vasc Biol Date: 2014-09-25 Impact factor: 8.311
Authors: Jason H Y Wu; Rozenn N Lemaitre; Irena B King; Xiaoling Song; Bruce M Psaty; David S Siscovick; Dariush Mozaffarian Journal: Circulation Date: 2014-08-14 Impact factor: 29.690
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Authors: C J Pepine; P F Cohn; P C Deedwania; R S Gibson; E Handberg; J A Hill; E Miller; R G Marks; U Thadani Journal: Circulation Date: 1994-08 Impact factor: 29.690
Authors: Yael F Meirovich; John P Veinot; Mercedes L Kuroski de Bold; Haissam Haddad; Ross A Davies; Roy G Masters; Paul J Hendry; Adolfo J de Bold Journal: J Heart Lung Transplant Date: 2008-01 Impact factor: 10.247
Authors: A M Richards; D McDonald; M A Fitzpatrick; M G Nicholls; E A Espiner; H Ikram; S Jans; S Grant; T Yandle Journal: J Clin Endocrinol Metab Date: 1988-12 Impact factor: 5.958
Authors: Jyrki K Virtanen; Jari A Laukkanen; Jaakko Mursu; Sari Voutilainen; Tomi-Pekka Tuomainen Journal: PLoS One Date: 2012-07-16 Impact factor: 3.240