Literature DB >> 270714

Nonintercalative binding of ethidium bromide to nucleic acids: crystal structure of an ethidium--tRNA molecular complex.

M Liebman, J Rubin, M Sundaralingam.   

Abstract

X-ray diffraction studies at 4.5-A resolution on crystals of a complex of ethidium bromide and yeast phenylalanine tRNA reveal a nonintercalative model of binding of the ethidium within the tertiary structure. This is contrary to the expected interacalative binding to the double-helical regions.

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Year:  1977        PMID： 270714      PMCID： PMC432047          DOI： 10.1073/pnas.74.11.4821

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  Trypanocidal action of phenanthridine compounds: further 2:7-diamino phenanthridinium compounds.

Authors:  G WOOLFE
Journal:  Br J Pharmacol Chemother       Date:  1956-09

2.  Ring-current effects in the Nmr of nucleic acids: a graphical approach.

Authors:  C Giessner-Prettre; B Pullman; P N Borer; L S Kan; P O Ts'o
Journal:  Biopolymers       Date:  1976-11       Impact factor: 2.505

3.  Atomic coordinates and molecular conformation of yeast phenylalanyl tRNA. An independent investigation.

Authors:  C D Stout; H Mizuno; J Rubin; T Brennan; S T Rao; M Sundaralingam
Journal:  Nucleic Acids Res       Date:  1976-04       Impact factor: 16.971

4.  Theoretical study on the proton chemical shifts of hydrogen bonded nucleic acid bases.

Authors:  C Giessner-Prettre; B Pullman; J Caillet
Journal:  Nucleic Acids Res       Date:  1977-01       Impact factor: 16.971

5.  Letter: Paramagnetic rare earth ion probes of transfer ribonucleic acid structure.

Authors:  C R Jones; D R Kearns
Journal:  J Am Chem Soc       Date:  1974-05-29       Impact factor: 15.419

6.  Tertiary hydrogen bonds in the solution structure of transfer RNA.

Authors:  B R Reid; N S Ribeiro; G Gould; G Robillard; C W Hilbers; R G Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

7.  tRNA conformation and magnesium binding. A study of a yeast phenylalanine-specific tRNA by a fluorescent indicator and differential melting curves.

Authors:  R Römer; R Hach
Journal:  Eur J Biochem       Date:  1975-06-16

8.  Mechanisms of chain folding in nucleic acids. The (omega, omega) plot and its correlation to the nucleotide geometry in yeast tRNAPhe1.

Authors:  M Sundaralingam; H Mizuno; C D Stout; S T Rao; M Liedman; N Yathindra
Journal:  Nucleic Acids Res       Date:  1976-10       Impact factor: 16.971

9.  Nuclear magnetic resonance of the base-pairing structure of the native and denatured conformers of Escherichia coli transfer RNATrp.

Authors:  C R Jones; D R Kearns
Journal:  J Mol Biol       Date:  1976-06-05       Impact factor: 5.469

10.  Similarity of the crystal and solution structure of yeast tRNAPhe.

Authors:  G T Robillard; C E Tarr; F Vosman; H J Berendsen
Journal:  Nature       Date:  1976-07-29       Impact factor: 49.962
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  8 in total

1.  Evidence for tertiary structure in natural single stranded RNAs in solution.

Authors:  S Ghribi; M C Maurel; M Rougee; A Favre
Journal:  Nucleic Acids Res       Date:  1988-02-11       Impact factor: 16.971

2.  Localization of the major ethidium bromide binding site on tRNA.

Authors:  W C Chu; J C Liu; J Horowitz
Journal:  Nucleic Acids Res       Date:  1997-10-01       Impact factor: 16.971

3.  Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites.

Authors:  N K Tanner; T R Cech
Journal:  Nucleic Acids Res       Date:  1985-11-11       Impact factor: 16.971

4.  Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes.

Authors:  N K Tanner; T R Cech
Journal:  Nucleic Acids Res       Date:  1985-11-11       Impact factor: 16.971

5.  Sugar pucker geometries at the intercalation site of propidium diiodide into miniature RNA and DNA duplexes in solution.

Authors:  D J Patel; C Shen
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

6.  Similar binding of the carcinostatic drugs cis-[Pt(NH3)2Cl2] and [Ru(NH3)5Cl] Cl2 to tRNAphe and a comparison with the binding of the inactive trans-[Pt(NH3)2Cl2] complex - reluctance in binding to Watson-Crick base pairs within double helix.

Authors:  J R Rubin; M Sabat; M Sundaralingam
Journal:  Nucleic Acids Res       Date:  1983-09-24       Impact factor: 16.971

7.  RNA structure analysis using methidiumpropyl-EDTA.Fe(II): a base-pair-specific RNA structure probe.

Authors:  C P Vary; J N Vournakis
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

8.  The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes.

Authors:  Andreea Prisecaru; Zara Molphy; Ralph G Kipping; Erica J Peterson; Yun Qu; Andrew Kellett; Nicholas P Farrell
Journal:  Nucleic Acids Res       Date:  2014-11-20       Impact factor: 16.971
  8 in total

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