Literature DB >> 27071003

17β-Hydroxy-18-acetoxywithanolides from Aeroponically Grown Physalis crassifolia and Their Potent and Selective Cytotoxicity for Prostate Cancer Cells.

Ya-ming Xu1, Daniel P Bunting1, Manping X Liu1, Hema A Bandaranayake1, A A Leslie Gunatilaka1.   

Abstract

When cultivated under aeroponic growth conditions, Physalis crassifolia produced 11 new withanolides (1-11) and seven known withanolides (12-18) including those obtained from the wild-crafted plant. The structures of the new withanolides were elucidated by the application of spectroscopic techniques, and the known withanolides were identified by comparison of their spectroscopic data with those reported. Withanolides 1-11 and 16 were evaluated for their potential anticancer activity using five tumor cell lines. Of these, the 17β-hydroxy-18-acetoxywithanolides 1, 2, 6, 7, and 16 showed potent antiproliferative activity, with some having selectivity for prostate adenocarcinoma (LNCaP and PC-3M) compared to the breast adenocarcinoma (MCF-7), non-small-cell lung cancer (NCI-H460), and CNS glioma (SF-268) cell lines used. The cytotoxicity data obtained for 12-15, 17, and 19 have provided additional structure-activity relationship information for the 17β-hydroxy-18-acetoxywithanolides.

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Year:  2016        PMID： 27071003     DOI： 10.1021/acs.jnatprod.5b00911

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.

Authors:  Ya-Ming Xu; E M Kithsiri Wijeratne; Ashley L Babyak; Hanna R Marks; Alan D Brooks; Poonam Tewary; Li-Jiang Xuan; Wen-Qiong Wang; Thomas J Sayers; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2017-06-15       Impact factor: 4.050

2.  17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships.

Authors:  Ya-Ming Xu; Alan D Brooks; E M Kithsiri Wijeratne; Curtis J Henrich; Poonam Tewary; Thomas J Sayers; A A Leslie Gunatilaka
Journal:  J Med Chem       Date:  2017-03-21       Impact factor: 7.446

3.  Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica.

Authors:  Ya-Ming Xu; E M Kithsiri Wijeratne; Alan D Brooks; Poonam Tewary; Li-Jiang Xuan; Wen-Qiong Wang; Thomas J Sayers; A A Leslie Gunatilaka
Journal:  Phytochemistry       Date:  2018-05-21       Impact factor: 4.072

4.  Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl.

Authors:  Ya-Ming Xu; E M Kithsiri Wijeratne; Manping X Liu; Lijiang Xuan; Wenqiong Wang; A A Leslie Gunatilaka
Journal:  Molecules       Date:  2022-01-28       Impact factor: 4.411

Review 5.  Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides.

Authors:  Amandeep Singh; Asif Raza; Shantu Amin; Chendil Damodaran; Arun K Sharma
Journal:  Molecules       Date:  2022-01-28       Impact factor: 4.411

6.  Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.

Authors:  Annika Stein; Dave Compera; Bianka Karge; Mark Brönstrup; Jakob Franke
Journal:  Beilstein J Org Chem       Date:  2019-08-23       Impact factor: 2.883

Review 7.  Hidden in Plants-A Review of the Anticancer Potential of the Solanaceae Family in In Vitro and In Vivo Studies.

Authors:  Tomasz Kowalczyk; Anna Merecz-Sadowska; Patricia Rijo; Mattia Mori; Sophia Hatziantoniou; Karol Górski; Janusz Szemraj; Janusz Piekarski; Tomasz Śliwiński; Michał Bijak; Przemysław Sitarek
Journal:  Cancers (Basel)       Date:  2022-03-11       Impact factor: 6.639
  7 in total

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