| Literature DB >> 27070053 |
Bruna Carletto1, Juliana Berton1, Tamara Nascimento Ferreira1, Luciana Facco Dalmolin1, Katia Sabrina Paludo2, Rubiana Mara Mainardes3, Paulo Vitor Farago4, Giovani Marino Favero5.
Abstract
In this study, resveratrol-loaded nanocapsules were developed and its antitumor activity tested on a melanoma mice model. These nanocapsules were spherically-shaped and presented suitable size, negative charge and high encapsulation efficiency for their use as a modified-release system of resveratrol. Nanoencapsulation leads to the drug amorphization. Resveratrol-loaded nanoparticles reduced cell viability of murine melanoma cells. There was a decrease in tumor volume, an increase in the necrotic area and inflammatory infiltrate of melanoma when resveratrol-loaded nanocapsules were compared to free resveratrol in treated mice. Nanoencapsulation of resveratrol also prevented metastasis and pulmonary hemorrhage. This modified-release technology containing resveratrol can be used as a feasible approach in order to inhibit murine melanoma tumor growth.Entities:
Keywords: B16F10 Cell line; Nanoparticles; PCL; Phytoalexin; Polymeric drug carrier
Mesh：
Substances：
Year: 2016 PMID： 27070053 DOI： 10.1016/j.colsurfb.2016.04.001
Source DB: PubMed Journal: Colloids Surf B Biointerfaces ISSN： 0927-7765 Impact factor: 5.268