Literature DB >> 27067961

Targeting clotting proteins in cancer therapy - progress and challenges.

Wolfram Ruf1, Andrea S Rothmeier2, Claudine Graf3.   

Abstract

Cancer-associated thrombosis remains a significant complication in the clinical management of cancer and interactions of the hemostatic system with cancer biology continue to be elucidated. Here, we review recent progress in our understanding of tissue factor (TF) regulation and procoagulant activation, TF signaling in cancer and immune cells, and the expanding roles of the coagulation system in stem cell niches and the tumor microenvironment. The extravascular functions of coagulant and anti-coagulant pathways have significant implications not only for tumor progression, but also for the selection of appropriate target specific anticoagulants in the therapy of cancer patients.
© 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Coagulation; Inflammation; Tissue factor; Tumor microenvironment

Mesh：

Substances：

Year:  2016        PMID： 27067961      PMCID： PMC5327857          DOI： 10.1016/S0049-3848(16)30090-1

Source DB:  PubMed          Journal:  Thromb Res        ISSN： 0049-3848            Impact factor:   3.944


  117 in total

1.  "Stemness": transcriptional profiling of embryonic and adult stem cells.

Authors:  Miguel Ramalho-Santos; Soonsang Yoon; Yumi Matsuzaki; Richard C Mulligan; Douglas A Melton
Journal:  Science       Date:  2002-09-12       Impact factor: 47.728

2.  A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).

Authors:  Subhra K Biswas; Lisa Gangi; Saki Paul; Tiziana Schioppa; Alessandra Saccani; Marina Sironi; Barbara Bottazzi; Andrea Doni; Bronte Vincenzo; Fabio Pasqualini; Luca Vago; Manuela Nebuloni; Alberto Mantovani; Antonio Sica
Journal:  Blood       Date:  2005-11-03       Impact factor: 22.113

3.  Coagulation factor VII is regulated by androgen receptor in breast cancer.

Authors:  Ali Naderi
Journal:  Exp Cell Res       Date:  2014-10-14       Impact factor: 3.905

4.  Disulfide isomerization switches tissue factor from coagulation to cell signaling.

Authors:  Jasimuddin Ahamed; Henri H Versteeg; Marjolein Kerver; Vivien M Chen; Barbara M Mueller; Philip J Hogg; Wolfram Ruf
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-07       Impact factor: 11.205

5.  Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.

Authors:  Jian-Guo Wang; Julia E Geddings; Maria M Aleman; Jessica C Cardenas; Pichika Chantrathammachart; Julie C Williams; Daniel Kirchhofer; Vladimir Y Bogdanov; Ronald R Bach; Janusz Rak; Frank C Church; Alisa S Wolberg; Rafal Pawlinski; Nigel S Key; Jen Jen Yeh; Nigel Mackman
Journal:  Blood       Date:  2012-04-30       Impact factor: 22.113

6.  Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia.

Authors:  Jasimuddin Ahamed; Frank Niessen; Toru Kurokawa; Young Kyung Lee; Gourab Bhattacharjee; James H Morrissey; Wolfram Ruf
Journal:  Blood       Date:  2007-03-01       Impact factor: 22.113

7.  Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys.

Authors:  Thomas W Geisbert; Lisa E Hensley; Peter B Jahrling; Tom Larsen; Joan B Geisbert; Jason Paragas; Howard A Young; Terry M Fredeking; William E Rote; George P Vlasuk
Journal:  Lancet       Date:  2003-12-13       Impact factor: 79.321

8.  Endothelial cell protein C receptor opposes mesothelioma growth driven by tissue factor.

Authors:  Shiva Keshava; Sanghamitra Sahoo; Torry A Tucker; Steven Idell; L Vijaya Mohan Rao; Usha R Pendurthi
Journal:  Cancer Res       Date:  2013-03-28       Impact factor: 12.701

9.  Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement.

Authors:  Geerte L Van Sluis; Tatjana M H Niers; Charles T Esmon; Wikky Tigchelaar; Dick J Richel; Harry R Buller; Cornelis J F Van Noorden; C Arnold Spek
Journal:  Blood       Date:  2009-07-01       Impact factor: 22.113

10.  Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice.

Authors:  Henri H Versteeg; Florence Schaffner; Marjolein Kerver; Lesley G Ellies; Patricia Andrade-Gordon; Barbara M Mueller; Wolfram Ruf
Journal:  Cancer Res       Date:  2008-09-01       Impact factor: 12.701
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  8 in total

1.  Regulation of Tissue Factor by CD44 Supports Coagulant Activity in Breast Tumor Cells.

Authors:  Amélie V Villard; Anthony Genna; Justine Lambert; Marianna Volpert; Agnès Noël; Brett Hollier; Myriam Polette; Aline M Vanwynsberghe; Christine Gilles
Journal:  Cancers (Basel)       Date:  2022-07-05       Impact factor: 6.575

Review 2.  Necrotic reshaping of the glioma microenvironment drives disease progression.

Authors:  Steven M Markwell; James L Ross; Cheryl L Olson; Daniel J Brat
Journal:  Acta Neuropathol       Date:  2022-01-17       Impact factor: 15.887

3.  Circulating Proteins Associated with Response and Resistance to Neoadjuvant Chemotherapy in HER2-Positive Breast Cancer.

Authors:  María Del Pilar Chantada-Vázquez; Mercedes Conde-Amboage; Lucía Graña-López; Sergio Vázquez-Estévez; Susana B Bravo; Cristina Núñez
Journal:  Cancers (Basel)       Date:  2022-02-21       Impact factor: 6.639

4.  Prognostic Impact of Coagulation Activity in Patients Undergoing Curative Resection for Pancreatic Ductal Adenocarcinoma.

Authors:  Kazuki Matsumura; Hiromitsu Hayashi; Norio Uemura; Liu Zhao; Takaaki Higashi; Takanobu Yamao; Fumimasa Kitamura; Yusuke Nakao; Toshihiko Yusa; Rumi Itoyama; Katsunori Imai; Yo-Ichi Yamashita; Hideo Baba
Journal:  In Vivo       Date:  2020 Sep-Oct       Impact factor: 2.155

5.  Thrombin cleavage of osteopontin initiates osteopontin's tumor-promoting activity.

Authors:  Sameera Peraramelli; Qi Zhou; Qin Zhou; Bettina Wanko; Lei Zhao; Toshihiko Nishimura; Thomas H Leung; Seiya Mizuno; Mamoru Ito; Timothy Myles; Thomas M Stulnig; John Morser; Lawrence L K Leung
Journal:  J Thromb Haemost       Date:  2022-02-16       Impact factor: 16.036

Review 6.  Potential Coagulation Factor-Driven Pro-Inflammatory Responses in Ovarian Cancer Tissues Associated with Insufficient O₂ and Plasma Supply.

Authors:  Shiro Koizume; Yohei Miyagi
Journal:  Int J Mol Sci       Date:  2017-04-12       Impact factor: 5.923

7.  Protein Corona Gold Nanoparticles Fingerprinting Reveals a Profile of Blood Coagulation Proteins in the Serum of HER2-Overexpressing Breast Cancer Patients.

Authors:  María Del Pilar Chantada-Vázquez; Antonio Castro López; María García-Vence; Benigno Acea-Nebril; Susana B Bravo; Cristina Núñez
Journal:  Int J Mol Sci       Date:  2020-11-10       Impact factor: 5.923

8.  Analyzing non-cancer causes of death of colorectal carcinoma patients in the US population for the years 2000-2016.

Authors:  Lili Lu; Li Ma; Xianbin Zhang; Christina Susanne Mullins; Michael Linnebacher
Journal:  Cancer Med       Date:  2020-12-13       Impact factor: 4.452
  8 in total

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