Literature DB >> 27065222

SCAP links glucose to lipid metabolism in cancer cells.

Deliang Guo1.   

Abstract

We recently uncovered that glucose is a critical activator of sterol regulatory element-binding proteins (SREBPs). Glucose promotes SREBP-cleavage activating protein (SCAP)/SREBP complex trafficking from the ER to the Golgi and subsequent SREBP activation via N-glycosylation of SCAP. Our study also demonstrated that SCAP plays a critical role in tumor growth.

Entities:  

Keywords:  N-glycosylation; SCAP; SREBPs; glioblastoma; glucose; lipid metabolism; tumor growth

Year:  2016        PMID： 27065222      PMCID： PMC4822554          DOI： 10.1080/23723556.2015.1132120

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Protein sensors for membrane sterols.

Authors:  Joseph L Goldstein; Russell A DeBose-Boyd; Michael S Brown
Journal:  Cell       Date:  2006-01-13       Impact factor: 41.582

2.  An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway.

Authors:  Deliang Guo; Felicia Reinitz; Mary Youssef; Cynthia Hong; David Nathanson; David Akhavan; Daisuke Kuga; Ali Nael Amzajerdi; Horacio Soto; Shaojun Zhu; Ivan Babic; Kazuhiro Tanaka; Julie Dang; Akio Iwanami; Beatrice Gini; Jason Dejesus; Dominique D Lisiero; Tiffany T Huang; Robert M Prins; Patrick Y Wen; H Ian Robins; Michael D Prados; Lisa M Deangelis; Ingo K Mellinghoff; Minesh P Mehta; C David James; Arnab Chakravarti; Timothy F Cloughesy; Peter Tontonoz; Paul S Mischel
Journal:  Cancer Discov       Date:  2011-09-15       Impact factor: 39.397

3.  AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas.

Authors:  Deliang Guo; Timothy F Cloughesy; Caius G Radu; Paul S Mischel
Journal:  Cell Cycle       Date:  2010-01-06       Impact factor: 4.534

Review 4.  Lipid metabolism emerges as a promising target for malignant glioma therapy.

Authors:  Deliang Guo; Erica Hlavin Bell; Arnab Chakravarti
Journal:  CNS Oncol       Date:  2013-05

Review 5.  Targeting SREBP-1-driven lipid metabolism to treat cancer.

Authors:  Deliang Guo; Erica Hlavin Bell; Paul Mischel; Arnab Chakravarti
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116

6.  EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.

Authors:  Deliang Guo; Robert M Prins; Julie Dang; Daisuke Kuga; Akio Iwanami; Horacio Soto; Kelly Y Lin; Tiffany T Huang; David Akhavan; M Benjamin Hock; Shaojun Zhu; Ava A Kofman; Steve J Bensinger; William H Yong; Harry V Vinters; Steve Horvath; Andrew D Watson; John G Kuhn; H Ian Robins; Minesh P Mehta; Patrick Y Wen; Lisa M DeAngelis; Michael D Prados; Ingo K Mellinghoff; Timothy F Cloughesy; Paul S Mischel
Journal:  Sci Signal       Date:  2009-12-15       Impact factor: 8.192

7.  The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis.

Authors:  Deliang Guo; Isabel J Hildebrandt; Robert M Prins; Horacio Soto; Mary M Mazzotta; Julie Dang; Johannes Czernin; John Y-J Shyy; Andrew D Watson; Michael Phelps; Caius G Radu; Timothy F Cloughesy; Paul S Mischel
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-22       Impact factor: 11.205

8.  Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

Authors:  A Nohturfft; M S Brown; J L Goldstein
Journal:  J Biol Chem       Date:  1998-07-03       Impact factor: 5.157

9.  Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.

Authors:  Chunming Cheng; Peng Ru; Feng Geng; Junfeng Liu; Ji Young Yoo; Xiaoning Wu; Xiang Cheng; Vanessa Euthine; Peng Hu; Jeffrey Yunhua Guo; Etienne Lefai; Balveen Kaur; Axel Nohturfft; Jianjie Ma; Arnab Chakravarti; Deliang Guo
Journal:  Cancer Cell       Date:  2015-11-09       Impact factor: 31.743

10.  Tumor metabolism of malignant gliomas.

Authors:  Peng Ru; Terence M Williams; Arnab Chakravarti; Deliang Guo
Journal:  Cancers (Basel)       Date:  2013-11-08       Impact factor: 6.639
  10 in total
  12 in total

1.  Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress.

Authors:  Xiang Cheng; Feng Geng; Meixia Pan; Xiaoning Wu; Yaogang Zhong; Chunyan Wang; Zhihua Tian; Chunming Cheng; Rui Zhang; Vinay Puduvalli; Craig Horbinski; Xiaokui Mo; Xianlin Han; Arnab Chakravarti; Deliang Guo
Journal:  Cell Metab       Date:  2020-06-18       Impact factor: 27.287

2.  microRNA-29 mediates a novel negative feedback loop to regulate SCAP/SREBP-1 and lipid metabolism.

Authors:  Peng Ru; Deliang Guo
Journal:  RNA Dis       Date:  2017-03-20

3.  Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.

Authors:  Peng Ru; Peng Hu; Feng Geng; Xiaokui Mo; Chunming Cheng; Ji Young Yoo; Xiang Cheng; Xiaoning Wu; Jeffrey Yunhua Guo; Ichiro Nakano; Etienne Lefai; Balveen Kaur; Arnab Chakravarti; Deliang Guo
Journal:  Cell Rep       Date:  2016-07-28       Impact factor: 9.423

4.  Lipid droplets, potential biomarker and metabolic target in glioblastoma.

Authors:  Feng Geng; Deliang Guo
Journal:  Intern Med Rev (Wash D C)       Date:  2017-05

Review 5.  SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy.

Authors:  Xiang Cheng; Jianying Li; Deliang Guo
Journal:  Curr Top Med Chem       Date:  2018       Impact factor: 3.295

6.  Analysis of SCAP N-glycosylation and Trafficking in Human Cells.

Authors:  Chunming Cheng; Jeffrey Yunhua Guo; Feng Geng; Xiaoning Wu; Xiang Cheng; Qiyue Li; Deliang Guo
Journal:  J Vis Exp       Date:  2016-11-08       Impact factor: 1.355

7.  Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth.

Authors:  Chunming Cheng; Feng Geng; Zoe Li; Yaogang Zhong; Huabao Wang; Xiang Cheng; Yue Zhao; Xiaokui Mo; Craig Horbinski; Wenrui Duan; Arnab Chakravarti; Xiaolin Cheng; Deliang Guo
Journal:  Nat Metab       Date:  2022-05-09

8.  Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.

Authors:  Feng Geng; Xiang Cheng; Xiaoning Wu; Ji Young Yoo; Chunming Cheng; Jeffrey Yunhua Guo; Xiaokui Mo; Peng Ru; Brian Hurwitz; Sung-Hak Kim; Jose Otero; Vinay Puduvalli; Etienne Lefai; Jianjie Ma; Ichiro Nakano; Craig Horbinski; Balveen Kaur; Arnab Chakravarti; Deliang Guo
Journal:  Clin Cancer Res       Date:  2016-06-08       Impact factor: 12.531

Review 9.  Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation.

Authors:  Chelsea Schiliro; Bonnie L Firestein
Journal:  Cells       Date:  2021-04-29       Impact factor: 6.600

10.  Tumorigenic proteins upregulated in the MYCN-amplified IMR-32 human neuroblastoma cells promote proliferation and migration.

Authors:  Hayat Zaatiti; Jad Abdallah; Zeina Nasr; George Khazen; Anthony Sandler; Tamara J Abou-Antoun
Journal:  Int J Oncol       Date:  2018-01-04       Impact factor: 5.650
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