| Literature DB >> 27065014 |
Yun Yan Su1, Zhaogang Teng1, Hui Yao2, Shou Ju Wang1, Ying Tian1, Yun Lei Zhang1, Wen Fei Liu1, Wei Tian1, Li Juan Zheng1, Nan Lu1, Qian Qian Ni1, Xiao Dan Su3, Yu Xia Tang1, Jing Sun1, Ying Liu1, Jiang Wu1, Gui Fen Yang1, Guang Ming Lu1, Long Jiang Zhang1.
Abstract
In this work, we design mesoporous silica-coated Prussian blue nanocubes with PEGyltation to construct multifunctional PB@mSiO2-PEG nanocubes. The PB@mSiO2-PEG nanocubes have good biocompatibility, excellent photothermal transformation capacity, in vivo magnetic resonance and photoacoustic imaging ability. After loading antitumor drug doxorubicin (DOX) in the PB@mSiO2-PEG nanocubes, the constructured PB@mSiO2-PEG/DOX nanoplatforms show an excellent pH-responsive drug release character within 48 h, namely, an ultralow cumulative drug release amount of 3.1% at pH 7.4 and a high release amount of 46.6% at pH 5.0. Upon near-infrared laser irradiation, the PB@mSiO2-PEG/DOX nanoplatforms show an enhanced synergistic photothermal and chemical therapeutic efficacy for breast cancer than solo photothermal therapy or chemotherapy.Entities:
Keywords: Prussian blue; magnetic resonance imaging; mesoporous silica; photoacoustic tomography; photothermo−chemotherapy
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Year: 2016 PMID： 27065014 DOI： 10.1021/acsami.6b01147
Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229