Literature DB >> 27064611

Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans.

Concetta Imperatore1, Paolo Luciano1, Anna Aiello1, Rocco Vitalone1, Carlo Irace2, Rita Santamaria2, Jia Li3, Yue-W Guo3, Marialuisa Menna1.   

Abstract

A new phosphorylated polyketide, phosphoeleganin (1), has been isolated from the Mediterranean ascidian Sidnyum elegans. Its structure and configuration have been determined by extensive use of 2D NMR and microscale chemical degradation and/or derivatization. Phosphoeleganin (1) inhibited the protein tyrosine phosphatase 1B (PTP1B) activity.

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Year:  2016        PMID： 27064611     DOI： 10.1021/acs.jnatprod.6b00063

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

Review 1.  Approaches to Configuration Determinations of Flexible Marine Natural Products: Advances and Prospects.

Authors:  Zong-Qing Huo; Feng Zhu; Xing-Wang Zhang; Xiao Zhang; Hong-Bao Liang; Jing-Chun Yao; Zhong Liu; Gui-Min Zhang; Qing-Qiang Yao; Guo-Fei Qin
Journal:  Mar Drugs       Date:  2022-05-19       Impact factor: 6.085

2.  Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone.

Authors:  Concetta Imperatore; Roberto Gimmelli; Marco Persico; Marcello Casertano; Alessandra Guidi; Fulvio Saccoccia; Giovina Ruberti; Paolo Luciano; Anna Aiello; Silvia Parapini; Sibel Avunduk; Nicoletta Basilico; Caterina Fattorusso; Marialuisa Menna
Journal:  Mar Drugs       Date:  2020-02-14       Impact factor: 5.118

3.  In Vitro Antiproliferative Evaluation of Synthetic Meroterpenes Inspired by Marine Natural Products.

Authors:  Concetta Imperatore; Gerardo Della Sala; Marcello Casertano; Paolo Luciano; Anna Aiello; Ilaria Laurenzana; Claudia Piccoli; Marialuisa Menna
Journal:  Mar Drugs       Date:  2019-12-05       Impact factor: 5.118

Review 4.  Marine Pharmacology in 2016-2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

Authors:  Alejandro M S Mayer; Aimee J Guerrero; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Fumiaki Nakamura; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2021-01-21       Impact factor: 5.118

5.  Dual Targeting of PTP1B and Aldose Reductase with Marine Drug Phosphoeleganin: A Promising Strategy for Treatment of Type 2 Diabetes.

Authors:  Massimo Genovese; Concetta Imperatore; Marcello Casertano; Anna Aiello; Francesco Balestri; Lucia Piazza; Marialuisa Menna; Antonella Del Corso; Paolo Paoli
Journal:  Mar Drugs       Date:  2021-09-24       Impact factor: 5.118

Review 6.  Ascidian Toxins with Potential for Drug Development.

Authors:  Dianne J Watters
Journal:  Mar Drugs       Date:  2018-05-13       Impact factor: 5.118

7.  Antiplasmodial Activity of p-Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections.

Authors:  Marcello Casertano; Marialuisa Menna; Caterina Fattorusso; Nicoletta Basilico; Silvia Parapini; Marco Persico; Concetta Imperatore
Journal:  Molecules       Date:  2020-03-27       Impact factor: 4.411

Review 8.  Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts.

Authors:  Xiaoju Dou; Bo Dong
Journal:  Mar Drugs       Date:  2019-11-28       Impact factor: 5.118

9.  Identifying Human PTP1B Enzyme Inhibitors from Marine Natural Products: Perspectives for Developing of Novel Insulin-Mimetic Drugs.

Authors:  Marcello Casertano; Massimo Genovese; Lucia Piazza; Francesco Balestri; Antonella Del Corso; Alessio Vito; Paolo Paoli; Alice Santi; Concetta Imperatore; Marialuisa Menna
Journal:  Pharmaceuticals (Basel)       Date:  2022-03-08
  9 in total

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