Literature DB >> 2706413

Tumour necrosis factor activity in joint fluids from rheumatoid arthritis patients.

M L Neale1, B D Williams, N Matthews.   

Abstract

Although tumour necrosis factor (TNF) was first studied as an anti-cancer agent it is now recognized as a potent mediator of inflammation and could potentially play a role in rheumatoid arthritis. In this study TNF activity has been sought in fluids from arthritic joints. TNF was assayed by a well established bioassay which depends upon cytolysis of particular tumour cell lines and which has a limit of detection of c. 25 pg/ml. Of the 92 joint fluids tested (70 rheumatoid and 22 others) only three had demonstrable TNF activity. Despite this, joint fluid cells from all 14 patients tested (12 rheumatoid and two others) had the ability to synthesize TNF on stimulation in vitro. Subsequently it was shown that joint fluids contain a macromolecule which inhibits TNF activity in cytolytic assays and which may mask low levels of TNF activity in joint fluids.

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Year:  1989        PMID： 2706413     DOI： 10.1093/rheumatology/28.2.104

Source DB:  PubMed          Journal:  Br J Rheumatol        ISSN： 0263-7103


  9 in total

1.  Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis.

Authors:  Jamie C Merrill; Jian You; Cara Constable; Susan E Leeman; Salomon Amar
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-12       Impact factor: 11.205

2.  A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment.

Authors:  F Myokai; S Takashiba; R Lebo; S Amar
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

3.  Human rheumatoid synovial cell stimulation by the membrane attack complex and other pore-forming toxins in vitro: the role of calcium in cell activation.

Authors:  R H Daniels; B D Williams; B P Morgan
Journal:  Immunology       Date:  1990-11       Impact factor: 7.397

Review 4.  Juvenile chronic arthritis, chronic iridocyclitis, and reactivity to histones.

Authors:  A M Leak; P Woo
Journal:  Ann Rheum Dis       Date:  1991-09       Impact factor: 19.103

5.  Influence of rheumatoid synovial fluid and cells on proteoglycans in human cartilage explants. Modulation by piroxicam.

Authors:  B Wilbrink; J Vernooy; W Den Otter; J L Van Roy; J Huber; O Huber-Bruning
Journal:  Clin Rheumatol       Date:  1992-03       Impact factor: 2.980

6.  Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice.

Authors:  Sreedevi Srinivasan; Susan E Leeman; Salomon Amar
Journal:  Clin Vaccine Immunol       Date:  2010-03-10

7.  Stimulation of human rheumatoid synovial cells by non-lethal complement membrane attack.

Authors:  R H Daniels; W A Houston; M M Petersen; J D Williams; B D Williams; B P Morgan
Journal:  Immunology       Date:  1990-02       Impact factor: 7.397

8.  Tumour necrosis factor alpha and interleukin-2 in plasma from rheumatoid arthritis patients in relation to disease activity.

Authors:  G T Espersen; M Vestergaard; E Ernst; N Grunnet
Journal:  Clin Rheumatol       Date:  1991-12       Impact factor: 2.980

9.  Circadian rhythm of serum interleukin-6 in rheumatoid arthritis.

Authors:  N G Arvidson; B Gudbjörnsson; L Elfman; A C Rydén; T H Tötterman; R Hällgren
Journal:  Ann Rheum Dis       Date:  1994-08       Impact factor: 19.103
  9 in total

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