| Literature DB >> 1582126 |
B Wilbrink1, J Vernooy, W Den Otter, J L Van Roy, J Huber, O Huber-Bruning.
Abstract
We have studied the effects of cell-free rheumatoid synovial fluid (RASF) and the conditioned medium (CM) from these cells on the proteoglycans (PGs) of normal human cartilage and the influence which piroxicam might have on these processes. Both RASF and the CM from RASF cells enhanced the PG release from the cartilage explants. The effects of the above mentioned fluids on the cartilage PG content depended on the metabolic state of the cartilage i.e. correlated inversely with the PG synthesis. Whether this was due to the presence of anabolic and catabolic factors in these fluids is discussed. Piroxicam had no adverse effect on the PGs of human cartilage in vitro. Piroxicam prevented the cartilage PG depletion when it was induced by the CM from RASF cells.Entities:
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Year: 1992 PMID： 1582126 DOI： 10.1007/bf02207091
Source DB: PubMed Journal: Clin Rheumatol ISSN： 0770-3198 Impact factor: 2.980