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Literature DB >> 27063403

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model.

Abstract

Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically relevant cell-cell and cell-matrix interactions, gene expression and signaling pathway profiles, heterogeneity and structural complexity that reflect in vivo tumors. In recent years, development of various 3D models has improved the study of host-tumor interaction and use of high-throughput screening platforms for anti-cancer drug discovery and development. This review attempts to summarize the various 3D culture systems, with an emphasis on the most well characterized and widely applied model - multicellular tumor spheroids. This review also highlights the various techniques to generate tumor spheroids, methods to characterize them, and its applicability in cancer research.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Apoptosis; High-throughput screening; Inflammatory breast cancer; Invasion; Oxidative stress; Tumor emboli

Mesh：

Substances：

Year: 2016 PMID： 27063403 PMCID： PMC4961208 DOI： 10.1016/j.pharmthera.2016.03.013

Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310

150 in total

Review 1. Nonlinear magic: multiphoton microscopy in the biosciences.

Authors: Warren R Zipfel; Rebecca M Williams; Watt W Webb
Journal: Nat Biotechnol Date: 2003-11 Impact factor: 54.908

2. Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids.

Authors: Maria Wartenberg; Edda Hoffmann; Heinrich Schwindt; Frank Grünheck; John Petros; J Rebecca S Arnold; Jürgen Hescheler; Heinrich Sauer
Journal: FEBS Lett Date: 2005-08-15 Impact factor: 4.124

3. Taking cell-matrix adhesions to the third dimension.

Authors: E Cukierman; R Pankov; D R Stevens; K M Yamada
Journal: Science Date: 2001-11-23 Impact factor: 47.728

4. HPLC and flow cytometric analyses of uptake of adriamycin and menogaril by monolayers and multicell spheroids.

Authors: T J Bichay; E G Adams; W R Inch; W J Adams; J E Brewer; B K Bhuyan
Journal: Sel Cancer Ther Date: 1990

5. Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion.

Authors: Joshua A Zimmermann; Todd C McDevitt
Journal: Cytotherapy Date: 2013-11-09 Impact factor: 5.414

6. Spheroid formation and invasion capacity are differentially influenced by co-cultures of fibroblast and macrophage cells in breast cancer.

Authors: Dorina Rama-Esendagli; Gunes Esendagli; Guldal Yilmaz; Dicle Guc
Journal: Mol Biol Rep Date: 2014-01-28 Impact factor: 2.316

7. In situ protein expression in tumour spheres: development of an immunostaining protocol for confocal microscopy.

Authors: Louis-Bastien Weiswald; Jean-Marc Guinebretière; Sophie Richon; Dominique Bellet; Bruno Saubaméa; Virginie Dangles-Marie
Journal: BMC Cancer Date: 2010-03-22 Impact factor: 4.430

8. Matrix crosslinking forces tumor progression by enhancing integrin signaling.

Authors: Kandice R Levental; Hongmei Yu; Laura Kass; Johnathon N Lakins; Mikala Egeblad; Janine T Erler; Sheri F T Fong; Katalin Csiszar; Amato Giaccia; Wolfgang Weninger; Mitsuo Yamauchi; David L Gasser; Valerie M Weaver
Journal: Cell Date: 2009-11-25 Impact factor: 41.582

9. Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy.

Authors: Corinne Lorenzo; Céline Frongia; Raphaël Jorand; Jérôme Fehrenbach; Pierre Weiss; Amina Maandhui; Guillaume Gay; Bernard Ducommun; Valérie Lobjois
Journal: Cell Div Date: 2011-12-12 Impact factor: 5.130

10. A spheroid-based 3-D culture model for pancreatic cancer drug testing, using the acid phosphatase assay.

Authors: Z Wen; Q Liao; Y Hu; L You; L Zhou; Y Zhao
Journal: Braz J Med Biol Res Date: 2013-07-22 Impact factor: 2.590

184 in total

1. Three-dimensional culture and clinical drug responses of a highly metastatic human ovarian cancer HO-8910PM cells in nanofibrous microenvironments of three hydrogel biomaterials.

Authors: Hong Song; Guo-Hui Cai; Jian Liang; Di-Shu Ao; Huan Wang; Ze-Hong Yang
Journal: J Nanobiotechnology Date: 2020-06-11 Impact factor: 10.435

Review 2. Cholangiocarcinoma 2020: the next horizon in mechanisms and management.

Authors: Jesus M Banales; Jose J G Marin; Angela Lamarca; Pedro M Rodrigues; Shahid A Khan; Lewis R Roberts; Vincenzo Cardinale; Guido Carpino; Jesper B Andersen; Chiara Braconi; Diego F Calvisi; Maria J Perugorria; Luca Fabris; Luke Boulter; Rocio I R Macias; Eugenio Gaudio; Domenico Alvaro; Sergio A Gradilone; Mario Strazzabosco; Marco Marzioni; Cédric Coulouarn; Laura Fouassier; Chiara Raggi; Pietro Invernizzi; Joachim C Mertens; Anja Moncsek; Sumera Rizvi; Julie Heimbach; Bas Groot Koerkamp; Jordi Bruix; Alejandro Forner; John Bridgewater; Juan W Valle; Gregory J Gores
Journal: Nat Rev Gastroenterol Hepatol Date: 2020-06-30 Impact factor: 46.802

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model.

Review 1. Nonlinear magic: multiphoton microscopy in the biosciences.

2. Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids.

3. Taking cell-matrix adhesions to the third dimension.

4. HPLC and flow cytometric analyses of uptake of adriamycin and menogaril by monolayers and multicell spheroids.

5. Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion.

6. Spheroid formation and invasion capacity are differentially influenced by co-cultures of fibroblast and macrophage cells in breast cancer.

7. In situ protein expression in tumour spheres: development of an immunostaining protocol for confocal microscopy.

8. Matrix crosslinking forces tumor progression by enhancing integrin signaling.

9. Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy.

10. A spheroid-based 3-D culture model for pancreatic cancer drug testing, using the acid phosphatase assay.

1. Three-dimensional culture and clinical drug responses of a highly metastatic human ovarian cancer HO-8910PM cells in nanofibrous microenvironments of three hydrogel biomaterials.

Review 2. Cholangiocarcinoma 2020: the next horizon in mechanisms and management.

Review 3. Opportunities and challenges in phenotypic drug discovery: an industry perspective.

Review 4. Advances in multicellular spheroids formation.

5. Engineering of vascularized 3D cell constructs to model cellular interactions through a vascular network.

Review 6. Current status and contemporary approaches to the discovery of antitumor agents from higher plants.

7. Relevance of humanized three-dimensional tumor tissue models: a descriptive systematic literature review.

8. Quantitative Proteomic and Phosphoproteomic Comparison of 2D and 3D Colon Cancer Cell Culture Models.

9. Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.

10. Optical Coherence Tomography Detects Necrotic Regions and Volumetrically Quantifies Multicellular Tumor Spheroids.