Literature DB >> 27063267

Nonalcoholic Fatty Liver Disease: Lipids and Insulin Resistance.

Paul D Berk1, Elizabeth C Verna2.   

Abstract

Obesity and its major comorbidities, including type 2 diabetes mellitus, nonalcoholic fatty liver disease (NAFLD), obesity cardiomyopathy, and certain cancers, have caused life expectancy in the United States to decline in recent years. Obesity is the increased accumulation of triglycerides (TG), which are synthesized from glycerol and long-chain fatty acids (LCFA) throughout the body. LCFA enter adipocytes, hepatocytes, and cardiomyocytes via specific, facilitated transport processes. Metabolism of increased cellular TG content in obesity may lead to comorbidities such as NAFLD and cardiomyopathy. Better understanding of LCFA transport processes may lead to successful treatment of obesity and NAFLD.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Facilitated transport; Leptin; Lipotoxicity; Spexin; Weight regain

Mesh：

Substances：

Year:  2016        PMID： 27063267      PMCID： PMC4830921          DOI： 10.1016/j.cld.2015.10.007

Source DB:  PubMed          Journal:  Clin Liver Dis        ISSN： 1089-3261            Impact factor:   6.126


  111 in total

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3.  Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake.

Authors:  D D Stump; X Fan; P D Berk
Journal:  J Lipid Res       Date:  2001-04       Impact factor: 5.922

4.  Identification of caveolin-1 as a fatty acid binding protein.

Authors:  B L Trigatti; R G Anderson; G E Gerber
Journal:  Biochem Biophys Res Commun       Date:  1999-02-05       Impact factor: 3.575

Review 5.  Lipotoxic diseases.

Authors:  Roger H Unger
Journal:  Annu Rev Med       Date:  2002       Impact factor: 13.739

6.  Noninvasive indices of fibrosis in NAFLD: starting to think about a three-hit (at least) phenomenon.

Authors:  Michael Charlton
Journal:  Am J Gastroenterol       Date:  2007-02       Impact factor: 10.864

7.  Transport of 13C-oleate in adipocytes measured using multi imaging mass spectrometry.

Authors:  Alan M Kleinfeld; J Patrick Kampf; Claude Lechene
Journal:  J Am Soc Mass Spectrom       Date:  2004-11       Impact factor: 3.109

Review 8.  Mechanisms of disease progression in nonalcoholic fatty liver disease.

Authors:  Janice Jou; Steve S Choi; Anna Mae Diehl
Journal:  Semin Liver Dis       Date:  2008-10-27       Impact factor: 6.115

9.  Hepatic steatosis and steatohepatitis: Are they really two distinct entities?

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Journal:  Curr Hepatol Rep       Date:  2014-06-01

10.  Facilitated long chain fatty acid uptake by adipocytes remains upregulated relative to BMI for more than a year after major bariatric surgical weight loss.

Authors:  Fengxia Ge; José L Walewski; Mehyar Hefazi Torghabeh; Harrison Lobdell; Chunguang Hu; Shengli Zhou; Gregory Dakin; Alfons Pomp; Marc Bessler; Beth Schrope; Aku Ude-Welcome; William B Inabnet; Tianshu Feng; Elektra Carras-Terzian; Dieunine Anglade; Faith E Ebel; Paul D Berk
Journal:  Obesity (Silver Spring)       Date:  2015-11-20       Impact factor: 5.002
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  18 in total

1.  An optimized method for measuring fatty acids and cholesterol in stable isotope-labeled cells.

Authors:  Joseph P Argus; Amy K Yu; Eric S Wang; Kevin J Williams; Steven J Bensinger
Journal:  J Lipid Res       Date:  2016-12-14       Impact factor: 5.922

2.  New Role of Hispidulin in Lipid Metabolism: PPARα Activator.

Authors:  Xinchi Wu; Juan Xu
Journal:  Lipids       Date:  2016-10-15       Impact factor: 1.880

3.  Synergism of Adipocytokine Profile and ADIPOQ/TNF-α Polymorphisms in NAFLD-associated MetS Predict Colorectal Liver Metastases Outgrowth.

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Journal:  Cancer Genomics Proteomics       Date:  2019 Nov-Dec       Impact factor: 4.069

Review 4.  Metabolic aspects of adult patients with nonalcoholic fatty liver disease.

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5.  Metabolic comparison of one-anastomosis gastric bypass, single-anastomosis duodenal-switch, Roux-en-Y gastric bypass, and vertical sleeve gastrectomy in rat.

Authors:  Deanna M Arble; Simon S Evers; Nadejda Bozadjieva; Henriette Frikke-Schmidt; Andriy Myronovych; Alfor Lewis; Mouhamadoul Habib Toure; Randy J Seeley
Journal:  Surg Obes Relat Dis       Date:  2018-08-29       Impact factor: 4.734

6.  Managing the Burden of Non-NASH NAFLD.

Authors:  Christopher J Danford; Jorge E Sanchez; Kathleen E Corey
Journal:  Curr Hepatol Rep       Date:  2017-10-27

Review 7.  Linking atrial fibrillation with non-alcoholic fatty liver disease: potential common therapeutic targets.

Authors:  Ya-Hui Ding; Yuan Ma; Lin-Yan Qian; Qiang Xu; Li-Hong Wang; Dong-Sheng Huang; Hai Zou
Journal:  Oncotarget       Date:  2017-07-24

8.  Inhibition of Adipocyte Differentiation by Anthocyanins Isolated from the Fruit of Vitis coignetiae Pulliat is Associated with the Activation of AMPK Signaling Pathway.

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Review 9.  Hepatic steatosis in HCV-infected persons in the direct-acting antiviral era.

Authors:  Heather L Stevenson; Netanya S Utay
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10.  Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus.

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Journal:  Front Endocrinol (Lausanne)       Date:  2021-07-02       Impact factor: 5.555
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