Literature DB >> 2706261

A molluscivorous Conus toxin: conserved frameworks in conotoxins.

D R Hillyard1, B M Olivera, S Woodward, G P Corpuz, W R Gray, C A Ramilo, L J Cruz.   

Abstract

We purified and characterized a 27 amino acid toxin from a snail-hunting Conus venom, Conus textile. This toxin causes convulsive-like activity in snails and causes subordinate lobsters to assume an exaggerated dominant posture. The sequence of this peptide is Trp-Cys-Lys-Gln-Ser-Gly-Glu-Met-Cys-Asn-Leu-Leu-Asp-Gln-Asn-Cys-Cys-Asp- Gly-Tyr-Cys-Ile-Val-Leu-Val-Cys-Thr. The sequence was confirmed by determining the nucleotide sequence of a cDNA clone coding for the peptide. The conservation of Cys residues compared to the omega-conotoxins from piscivorous Conus venom suggests that toxins from different cone venoms may use only a few "Cys-motifs" as conserved structural backbones for targeting to a variety of receptors in different animals.

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Year:  1989        PMID： 2706261     DOI： 10.1021/bi00427a049

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  17 in total

1.  Molecular genetics of ecological diversification: duplication and rapid evolution of toxin genes of the venomous gastropod Conus.

Authors:  T F Duda; S R Palumbi
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-08       Impact factor: 11.205

2.  Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus.

Authors:  Joseph W Aman; Julita S Imperial; Beatrix Ueberheide; Min-Min Zhang; Manuel Aguilar; Dylan Taylor; Maren Watkins; Doju Yoshikami; Patrice Showers-Corneli; Helena Safavi-Hemami; Jason Biggs; Russell W Teichert; Baldomero M Olivera
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-06       Impact factor: 11.205

Review 3.  Animal toxins influence voltage-gated sodium channel function.

Authors:  John Gilchrist; Baldomero M Olivera; Frank Bosmans
Journal:  Handb Exp Pharmacol       Date:  2014

4.  A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications.

Authors:  Zachary L Bergeron; Joycelyn B Chun; Margaret R Baker; David W Sandall; Steve Peigneur; Peter Y C Yu; Parashar Thapa; Jeffrey W Milisen; Jan Tytgat; Bruce G Livett; Jon-Paul Bingham
Journal:  Peptides       Date:  2013-09-18       Impact factor: 3.750

5.  Divergent M- and O-superfamily peptides from venom of fish-hunting Conus parius.

Authors:  Elsie C Jimenez; Baldomero M Olivera
Journal:  Peptides       Date:  2010-06-04       Impact factor: 3.750

6.  Identification and characterization of a Ca(2+)-sensitive nonspecific cation channel underlying prolonged repetitive firing in Aplysia neurons.

Authors:  G F Wilson; F C Richardson; T E Fisher; B M Olivera; L K Kaczmarek
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

Review 7.  The insecticidal potential of venom peptides.

Authors:  Jennifer J Smith; Volker Herzig; Glenn F King; Paul F Alewood
Journal:  Cell Mol Life Sci       Date:  2013-03-23       Impact factor: 9.261

8.  The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds.

Authors:  Nicolas Puillandre; Mandë Holford
Journal:  BMC Chem Biol       Date:  2010-09-17

9.  Rapid sensitive analysis of cysteine rich peptide venom components.

Authors:  Beatrix M Ueberheide; David Fenyö; Paul F Alewood; Brian T Chait
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-20       Impact factor: 11.205

10.  Characterization of a baculovirus gene encoding a small conotoxinlike polypeptide.

Authors:  R Eldridge; Y Li; L K Miller
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103
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