Literature DB >> 24737238

Animal toxins influence voltage-gated sodium channel function.

John Gilchrist1, Baldomero M Olivera, Frank Bosmans.   

Abstract

Voltage-gated sodium (Nav) channels are essential contributors to neuronal excitability, making them the most commonly targeted ion channel family by toxins found in animal venoms. These molecules can be used to probe the functional aspects of Nav channels on a molecular level and to explore their physiological role in normal and diseased tissues. This chapter summarizes our existing knowledge of the mechanisms by which animal toxins influence Nav channels as well as their potential application in designing therapeutic drugs.

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Year:  2014        PMID： 24737238      PMCID： PMC5453185          DOI： 10.1007/978-3-642-41588-3_10

Source DB:  PubMed          Journal:  Handb Exp Pharmacol        ISSN： 0171-2004


  192 in total

1.  Molecular determinants of binding of a wasp toxin (PMTXs) and its analogs in the Na+ channels proteins.

Authors:  K Konno; M Hisada; H Naoki; Y Itagaki; T Yasuhara; Y Nakata; A Miwa; N Kawai
Journal:  Neurosci Lett       Date:  2000-05-05       Impact factor: 3.046

2.  Propagation of electrical signals along giant nerve fibers.

Authors:  A L HODGKIN; A F HUXLEY
Journal:  Proc R Soc Lond B Biol Sci       Date:  1952-10-16

3.  Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop.

Authors:  Joacir Stolarz Oliveira; Elisa Redaelli; André J Zaharenko; Rita Restano Cassulini; Katsuhiro Konno; Daniel C Pimenta; José C Freitas; Jeffrey J Clare; Enzo Wanke
Journal:  J Biol Chem       Date:  2004-05-28       Impact factor: 5.157

4.  Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage-dependent Na+ channel.

Authors:  A Lombet; J N Bidard; M Lazdunski
Journal:  FEBS Lett       Date:  1987-07-27       Impact factor: 4.124

5.  Modification of cardiac Na+ channels by batrachotoxin: effects on gating, kinetics, and local anesthetic binding.

Authors:  J A Wasserstrom; K Liberty; J Kelly; P Santucci; M Myers
Journal:  Biophys J       Date:  1993-07       Impact factor: 4.033

6.  The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

Authors:  M F Sheets; J W Kyle; R G Kallen; D A Hanck
Journal:  Biophys J       Date:  1999-08       Impact factor: 4.033

7.  Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels.

Authors:  Fabiana V Campos; Baron Chanda; Paulo S L Beirão; Francisco Bezanilla
Journal:  J Gen Physiol       Date:  2008-08       Impact factor: 4.086

8.  ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.

Authors:  William A Schmalhofer; Jeffrey Calhoun; Rachel Burrows; Timothy Bailey; Martin G Kohler; Adam B Weinglass; Gregory J Kaczorowski; Maria L Garcia; Martin Koltzenburg; Birgit T Priest
Journal:  Mol Pharmacol       Date:  2008-08-26       Impact factor: 4.436

9.  A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.

Authors:  G M Lipkind; H A Fozzard
Journal:  Biophys J       Date:  1994-01       Impact factor: 4.033

10.  Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.

Authors:  Deborah L Capes; Manoel Arcisio-Miranda; Brian W Jarecki; Robert J French; Baron Chanda
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205
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  28 in total

1.  PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels.

Authors:  Lingxin Wang; Shannon G Zellmer; David M Printzenhoff; Neil A Castle
Journal:  Br J Pharmacol       Date:  2018-06-03       Impact factor: 8.739

2.  Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Authors:  Julie K Klint; Jennifer J Smith; Irina Vetter; Darshani B Rupasinghe; Sing Yan Er; Sebastian Senff; Volker Herzig; Mehdi Mobli; Richard J Lewis; Frank Bosmans; Glenn F King
Journal:  Br J Pharmacol       Date:  2015-03-04       Impact factor: 8.739

3.  Mapping the Molecular Surface of the Analgesic NaV1.7-Selective Peptide Pn3a Reveals Residues Essential for Membrane and Channel Interactions.

Authors:  Alexander Mueller; Zoltan Dekan; Quentin Kaas; Akello J Agwa; Hana Starobova; Paul F Alewood; Christina I Schroeder; Mehdi Mobli; Jennifer R Deuis; Irina Vetter
Journal:  ACS Pharmacol Transl Sci       Date:  2020-02-19

4.  Synthesis and Biological Activity of Scyllatoxin-Based BH3 Domain Mimetics Containing Two Disulfide Linkages.

Authors:  Danushka Arachchige; Justin M Holub
Journal:  Protein J       Date:  2018-10       Impact factor: 2.371

5.  Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation.

Authors:  Lingxin Wang; Shannon G Zellmer; David M Printzenhoff; Neil A Castle
Journal:  Br J Pharmacol       Date:  2015-10-15       Impact factor: 8.739

6.  Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.

Authors:  Anatoly Shcherbatko; Andrea Rossi; Davide Foletti; Guoyun Zhu; Oren Bogin; Meritxell Galindo Casas; Mathias Rickert; Adela Hasa-Moreno; Victor Bartsevich; Andreas Crameri; Alexander R Steiner; Robert Henningsen; Avinash Gill; Jaume Pons; David L Shelton; Arvind Rajpal; Pavel Strop
Journal:  J Biol Chem       Date:  2016-04-22       Impact factor: 5.157

Review 7.  Voltage-Gated Na+ Channels: Not Just for Conduction.

Authors:  Larisa C Kruger; Lori L Isom
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-06-01       Impact factor: 10.005

Review 8.  Using voltage-sensor toxins and their molecular targets to investigate NaV 1.8 gating.

Authors:  John Gilchrist; Frank Bosmans
Journal:  J Physiol       Date:  2018-01-06       Impact factor: 5.182

9.  Pharmacological Inhibition of the Voltage-Gated Sodium Channel NaV1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome.

Authors:  Yan Jiang; Joel Castro; Linda V Blomster; Akello J Agwa; Jessica Maddern; Gudrun Schober; Volker Herzig; Chun Yuen Chow; Fernanda C Cardoso; Paula Demétrio De Souza França; Junior Gonzales; Christina I Schroeder; Steffen Esche; Thomas Reiner; Stuart M Brierley; Glenn F King
Journal:  ACS Pharmacol Transl Sci       Date:  2021-06-07

Review 10.  Structural Pharmacology of TRP Channels.

Authors:  Yaxian Zhao; Bridget M McVeigh; Vera Y Moiseenkova-Bell
Journal:  J Mol Biol       Date:  2021-03-05       Impact factor: 6.151
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