Literature DB >> 27061006

DNA Methylation of ADME Genes.

P Fisel1,2, E Schaeffeler1,2, M Schwab1,3,4.   

Abstract

The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematically outlines the influence of DNA methylation on ADME gene expression and highlights the consequences for interindividual variability in drug response or drug-induced toxicity and the implications for personalized medicine.
© 2016 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2016        PMID： 27061006     DOI： 10.1002/cpt.343

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  17 in total

Review 1.  Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity.

Authors:  Volker M Lauschke; Yitian Zhou; Magnus Ingelman-Sundberg
Journal:  Pharmacol Ther       Date:  2019-01-22       Impact factor: 12.310

Review 2.  Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery.

Authors:  Ogheneochukome Lolodi; Yue-Ming Wang; William C Wright; Taosheng Chen
Journal:  Curr Drug Metab       Date:  2017       Impact factor: 3.731

3.  Analysis of bladder cancer tumor CpG methylation and gene expression within The Cancer Genome Atlas identifies GRIA1 as a prognostic biomarker for basal-like bladder cancer.

Authors:  Sloane K Tilley; William Y Kim; Rebecca C Fry
Journal:  Am J Cancer Res       Date:  2017-09-01       Impact factor: 6.166

4.  The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance.

Authors:  Vineet Kumar; Jia Yin; Sarah Billington; Bhagwat Prasad; Colin D A Brown; Joanne Wang; Jashvant D Unadkat
Journal:  Drug Metab Dispos       Date:  2018-08-09       Impact factor: 3.922

5.  Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes.

Authors:  Stefan Winter; Pascale Fisel; Florian Büttner; Steffen Rausch; Debora D'Amico; Jörg Hennenlotter; Stephan Kruck; Anne T Nies; Arnulf Stenzl; Kerstin Junker; Marcus Scharpf; Ute Hofmann; Heiko van der Kuip; Falko Fend; German Ott; Abbas Agaimy; Arndt Hartmann; Jens Bedke; Matthias Schwab; Elke Schaeffeler
Journal:  Sci Rep       Date:  2016-07-20       Impact factor: 4.379

Review 6.  Precision medicine: from pharmacogenomics to pharmacoproteomics.

Authors:  Allison B Chambliss; Daniel W Chan
Journal:  Clin Proteomics       Date:  2016-09-26       Impact factor: 3.988

7.  Combined study of genetic and epigenetic biomarker risperidone treatment efficacy in Chinese Han schizophrenia patients.

Authors:  Y Shi; M Li; C Song; Q Xu; R Huo; L Shen; Q Xing; D Cui; W Li; J Zhao; L He; S Qin
Journal:  Transl Psychiatry       Date:  2017-07-11       Impact factor: 6.222

8.  DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.

Authors:  Mohamad M Kronfol; Fay M Jahr; Mikhail G Dozmorov; Palak S Phansalkar; Lin Y Xie; Karolina A Aberg; MaryPeace McRae; Elvin T Price; Patricia W Slattum; Philip M Gerk; Joseph L McClay
Journal:  Geroscience       Date:  2020-03-27       Impact factor: 7.713

9.  Histone acetylation at the sulfotransferase 1a1 gene is associated with its hepatic expression in normal aging.

Authors:  Mohamad M Kronfol; Sara Abudahab; Mikhail G Dozmorov; Fay M Jahr; Matthew S Halquist; MaryPeace McRae; Dayanjan S Wijesinghe; Elvin T Price; Patricia W Slattum; Joseph L McClay
Journal:  Pharmacogenet Genomics       Date:  2021-12-01       Impact factor: 2.089

Review 10.  The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity.

Authors:  Volker M Lauschke; Magnus Ingelman-Sundberg
Journal:  Int J Mol Sci       Date:  2016-10-12       Impact factor: 5.923
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