Colette M Smart1,2, Sidney J Segalowitz3,4, Bryce P Mulligan1, Jacob Koudys1, Jodie R Gawryluk1. 1. Department of Psychology, University of Victoria, Victoria, BC, Canada. 2. Centre on Aging, University of Victoria, Victoria, BC, Canada. 3. Department of Psychology Brock University, St. Catharines, ON, Canada. 4. Jack & Nora Walker Centre for Lifespan Development Research, Brock University, St. Catharines, ON, Canada.
Abstract
INTRODUCTION:Subjective cognitive decline (SCD) in older adults is a condition with a complex phenomenology and diverse etiologies including (but not limited to) mood, personality, and health concerns, as well as biomarkers of preclinical Alzheimer's disease such as amyloid-β deposition and gray matter volume loss. Approximately 60% of affected persons are estimated to decline to Alzheimer's dementia. Regardless of etiology, persons with SCD may be optimal targets for early intervention. OBJECTIVE: To ascertain the feasibility and impact of mindfulness training (MT) as an early intervention in persons with SCD. METHODS: Using a single-blind, randomized controlled trial design, older adults with (n = 14) and without (n = 22) SCD were randomized to either MT or a control condition of psychoeducation (PE) on cognitive aging. EEG/ERP (specifically, the P3 component), structural MRI, and self-report measures of psychological functioning were obtained within 4 weeks prior to and within 2 weeks following intervention. RESULTS:MT resulted in decreased reaction time intra-individual variability for all participants, with a selective increase in the P3 event-related component for those with SCD. Compared with PE, MT also resulted in an increase in percent volume brain change in structural MRI. Finally, all SCD participants reported a decrease in cognitive complaints and increase in memory self-efficacy following intervention. DISCUSSION: Results suggest that MT is a feasible early intervention in persons with SCD. Longer-term follow-up with larger sample sizes will determine whether MT can slow the rate of decline in persons who may be at risk for Alzheimer's dementia.
RCT Entities:
INTRODUCTION: Subjective cognitive decline (SCD) in older adults is a condition with a complex phenomenology and diverse etiologies including (but not limited to) mood, personality, and health concerns, as well as biomarkers of preclinical Alzheimer's disease such as amyloid-β deposition and gray matter volume loss. Approximately 60% of affected persons are estimated to decline to Alzheimer's dementia. Regardless of etiology, persons with SCD may be optimal targets for early intervention. OBJECTIVE: To ascertain the feasibility and impact of mindfulness training (MT) as an early intervention in persons with SCD. METHODS: Using a single-blind, randomized controlled trial design, older adults with (n = 14) and without (n = 22) SCD were randomized to either MT or a control condition of psychoeducation (PE) on cognitive aging. EEG/ERP (specifically, the P3 component), structural MRI, and self-report measures of psychological functioning were obtained within 4 weeks prior to and within 2 weeks following intervention. RESULTS: MT resulted in decreased reaction time intra-individual variability for all participants, with a selective increase in the P3 event-related component for those with SCD. Compared with PE, MT also resulted in an increase in percent volume brain change in structural MRI. Finally, all SCDparticipants reported a decrease in cognitive complaints and increase in memory self-efficacy following intervention. DISCUSSION: Results suggest that MT is a feasible early intervention in persons with SCD. Longer-term follow-up with larger sample sizes will determine whether MT can slow the rate of decline in persons who may be at risk for Alzheimer's dementia.
Authors: Colette M Smart; Justin E Karr; Corson N Areshenkoff; Laura A Rabin; Carol Hudon; Nicola Gates; Jordan I Ali; Eider M Arenaza-Urquijo; Rachel F Buckley; Gael Chetelat; Harald Hampel; Frank Jessen; Natalie L Marchant; Sietske A M Sikkes; Andrea Tales; Wiesje M van der Flier; Linda Wesselman Journal: Neuropsychol Rev Date: 2017-03-07 Impact factor: 7.444
Authors: Rebecca Erwin Wells; Catherine Kerr; Michelle L Dossett; Suzanne C Danhauer; Stephanie J Sohl; Bonnie C Sachs; Jacquelyn Walsh Feeley; Jennifer Wolkin; Robert Wall; Ted Kaptchuk; Daniel Z Press; Russell S Phillips; Gloria Y Yeh Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: José L Molinuevo; Laura A Rabin; Rebecca Amariglio; Rachel Buckley; Bruno Dubois; Kathryn A Ellis; Michael Ewers; Harald Hampel; Stefan Klöppel; Lorena Rami; Barry Reisberg; Andrew J Saykin; Sietske Sikkes; Colette M Smart; Beth E Snitz; Reisa Sperling; Wiesje M van der Flier; Michael Wagner; Frank Jessen Journal: Alzheimers Dement Date: 2016-11-05 Impact factor: 21.566
Authors: Christopher R Brydges; Michelle C Carlson; Ryan M Andrews; George W Rebok; Allison A M Bielak Journal: J Gerontol B Psychol Sci Soc Sci Date: 2021-03-14 Impact factor: 4.077