Literature DB >> 27059793

Guidelines for the withdrawal of life-sustaining measures.

James Downar1, Jesse W Delaney2, Laura Hawryluck3, Lisa Kenny4.   

Abstract

BACKGROUND: Withdrawal of life-sustaining measures is a common event in the intensive care unit yet it involves a complex balance of medical, legal and ethical considerations. Very few healthcare providers have been specifically trained to withdraw life-sustaining measures, and no comprehensive guidelines exist to help ensure clinicians deliver the highest quality of care to patients and families. Hence, we sought to develop guidelines for the process of withdrawing life-sustaining measures in the clinical setting.
METHODS: We convened an interdisciplinary group of ICU care providers from the Canadian Critical Care Society and the Canadian Association of Critical Care Nurses, and used a modified Delphi process to answer key clinical and ethical questions identified in the literature.
RESULTS: A total of 39 experienced clinicians completed the initial workshop, and 36 were involved in the subsequent Delphi rounds. The group developed a series of guidelines to address (1) preparing for withdrawal of life-sustaining measures; (2) assessment of distress; (3) pharmaceutical management of distress; and (4) discontinuation of life-sustaining measures and monitoring. The group achieved consensus on all aspects of the guidelines after the third Delphi round.
CONCLUSION: We present these guidelines to help physicians provide high-quality end of life (EOL) care in the ICU. Future studies should address their effectiveness from both critical care team and family perspectives.

Entities:  

Keywords:  Consensus; Critical care; Delphi technique; Life support care; Palliative care; Standards; Terminal care

Mesh:

Year:  2016        PMID: 27059793     DOI: 10.1007/s00134-016-4330-7

Source DB:  PubMed          Journal:  Intensive Care Med        ISSN: 0342-4642            Impact factor:   17.440


  36 in total

1.  Withholding or withdrawal of life support: the Canadian Critical Care Society position paper.

Authors:  G Rocker; S Dunbar
Journal:  J Palliat Care       Date:  2000-10       Impact factor: 2.250

Review 2.  Practical guidelines on the withdrawal of life-sustaining therapies.

Authors:  A F Cist; R D Truog; S E Brackett; W E Hurford
Journal:  Int Anesthesiol Clin       Date:  2001

3.  Information for patients and families about ventilator withdrawal.

Authors:  Charles von Gunten; David E Weissman
Journal:  J Palliat Med       Date:  2003-10       Impact factor: 2.947

Review 4.  How to withdraw mechanical ventilation: a systematic review of the literature.

Authors:  Margaret L Campbell
Journal:  AACN Adv Crit Care       Date:  2007 Oct-Dec

5.  GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

Authors:  Gordon H Guyatt; Andrew D Oxman; Gunn E Vist; Regina Kunz; Yngve Falck-Ytter; Pablo Alonso-Coello; Holger J Schünemann
Journal:  BMJ       Date:  2008-04-26

6.  A national survey of end-of-life care for critically ill patients.

Authors:  T J Prendergast; M T Claessens; J M Luce
Journal:  Am J Respir Crit Care Med       Date:  1998-10       Impact factor: 21.405

Review 7.  Dying with dignity in the intensive care unit.

Authors:  Deborah Cook; Graeme Rocker
Journal:  N Engl J Med       Date:  2014-06-26       Impact factor: 91.245

8.  The infusion of opioids during terminal withdrawal of mechanical ventilation in the medical intensive care unit.

Authors:  Mark A Mazer; Chad M Alligood; Qiang Wu
Journal:  J Pain Symptom Manage       Date:  2011-01-13       Impact factor: 3.612

9.  Withdrawal of life support in the neurological intensive care unit.

Authors:  S A Mayer; S B Kossoff
Journal:  Neurology       Date:  1999-05-12       Impact factor: 9.910

Review 10.  Terminal dyspnea and respiratory distress.

Authors:  Margaret L Campbell
Journal:  Crit Care Clin       Date:  2004-07       Impact factor: 3.598

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  38 in total

Review 1.  A few realistic questions raised by organ retrieval in the intensive care unit.

Authors:  Olivier Lesieur; Liliane Genteuil; Maxime Leloup
Journal:  Ann Transl Med       Date:  2017-12

2.  Deceased organ and tissue donation after medical assistance in dying and other conscious and competent donors: guidance for policy.

Authors:  James Downar; Sam D Shemie; Clay Gillrie; Marie-Chantal Fortin; Amber Appleby; Daniel Z Buchman; Christen Shoesmith; Aviva Goldberg; Vanessa Gruben; Jehan Lalani; Dirk Ysebaert; Lindsay Wilson; Michael D Sharpe
Journal:  CMAJ       Date:  2019-06-03       Impact factor: 8.262

3.  Incidence and Risk Model Development for Severe Tachypnea Following Terminal Extubation.

Authors:  Corey R Fehnel; Miguel Armengol de la Hoz; Leo A Celi; Margaret L Campbell; Khalid Hanafy; Ala Nozari; Douglas B White; Susan L Mitchell
Journal:  Chest       Date:  2020-04-28       Impact factor: 9.410

4.  Addressing uncertainty: what is the role of consensus in end-of-life care?

Authors:  Ann C Long; Peter E Spronk; Charles L Sprung
Journal:  Intensive Care Med       Date:  2016-04-07       Impact factor: 17.440

5.  The Canadian guidelines for the withdrawal of life-sustaining treatment: the role of evidence.

Authors:  Mohamed Y Rady; Joseph L Verheijde
Journal:  Intensive Care Med       Date:  2016-05-25       Impact factor: 17.440

6.  Neither guidelines nor symptom-targeted opioids are harmful when withdrawing life-sustaining measures.

Authors:  James Downar; Jesse Delaney; Laura Hawryluck; Lisa Kenny
Journal:  Intensive Care Med       Date:  2016-05-25       Impact factor: 17.440

7.  Focus on palliative care in the ICU.

Authors:  Crystal E Brown; Dominique D Benoit; J Randall Curtis
Journal:  Intensive Care Med       Date:  2017-09-20       Impact factor: 17.440

8.  Terminal weaning or immediate extubation for withdrawing mechanical ventilation in critically ill patients (the ARREVE observational study).

Authors:  René Robert; Amélie Le Gouge; Nancy Kentish-Barnes; Alice Cottereau; Bruno Giraudeau; Mélanie Adda; Djillali Annane; Juliette Audibert; François Barbier; Patrick Bardou; Simon Bourcier; Jeremy Bourenne; Alexandre Boyer; François Brenas; Vincent Das; Arnaud Desachy; Jérôme Devaquet; Marc Feissel; Frédérique Ganster; Maïté Garrouste-Orgeas; Guillaume Grillet; Olivier Guisset; Rebecca Hamidfar-Roy; Anne-Claire Hyacinthe; Sebastien Jochmans; Mercé Jourdain; Alexandre Lautrette; Nicolas Lerolle; Olivier Lesieur; Fabien Lion; Philippe Mateu; Bruno Megarbane; Sybille Merceron; Emmanuelle Mercier; Jonathan Messika; Paul Morin-Longuet; Bénédicte Philippon-Jouve; Jean-Pierre Quenot; Anne Renault; Xavier Repesse; Jean-Philippe Rigaud; Ségolène Robin; Antoine Roquilly; Amélie Seguin; Didier Thevenin; Patrice Tirot; Isabelle Vinatier; Elie Azoulay; Jean Reignier
Journal:  Intensive Care Med       Date:  2017-09-22       Impact factor: 17.440

9.  Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.

Authors:  John G Laffey; Giacomo Bellani; Tài Pham; Eddy Fan; Fabiana Madotto; Ednan K Bajwa; Laurent Brochard; Kevin Clarkson; Andres Esteban; Luciano Gattinoni; Frank van Haren; Leo M Heunks; Kiyoyasu Kurahashi; Jon Henrik Laake; Anders Larsson; Daniel F McAuley; Lia McNamee; Nicolas Nin; Haibo Qiu; Marco Ranieri; Gordon D Rubenfeld; B Taylor Thompson; Hermann Wrigge; Arthur S Slutsky; Antonio Pesenti
Journal:  Intensive Care Med       Date:  2016-10-18       Impact factor: 17.440

10.  Ten key points about ICU palliative care.

Authors:  Jeffrey D Edwards; Louis P Voigt; Judith E Nelson
Journal:  Intensive Care Med       Date:  2016-08-09       Impact factor: 17.440

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