| Literature DB >> 27058839 |
Kalpana Deepa Priya Dorayappan1, John J Wallbillich1, David E Cohn1, Karuppaiyah Selvendiran2.
Abstract
Exosomes are nano-sized (20-100nm) vesicles released by a variety of cells and are generated within the endosomal system or at the plasma membrane. There is emerging evidence that exosomes play a key role in intercellular communication in ovarian and other cancers. The protein and microRNA content of exosomes has been implicated in various intracellular processes that mediate oncogenesis, tumor spread, and drug resistance. Exosomes may prime distant tissue sites for reception of future metastases and their release can be mediated by the tumor microenvironment (e.g., hypoxia). Ovarian cancer-derived exosomes have unique features that could be leveraged for use as biomarkers to facilitate improved detection and treatment of the disease. Further, exosomes have the potential to serve as targets and/or drug delivery vehicles in the treatment of ovarian cancer. In this review we discuss the biological and clinical significance of exosomes relevant to the progression, detection, and treatment of ovarian cancer.Entities:
Keywords: Bio-marker; Exosomes; Hypoxia; Ovarian cancer; micro RNA
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Year: 2016 PMID： 27058839 PMCID： PMC4917458 DOI： 10.1016/j.ygyno.2016.03.036
Source DB: PubMed Journal: Gynecol Oncol ISSN： 0090-8258 Impact factor: 5.482