Literature DB >> 27058514

Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS.

Natacha Bonneau1, Isabelle Schmitz-Afonso2, Alain Brunelle2, David Touboul2, Pierre Champy3.   

Abstract

The Annonaceous acetogenin annonacin is an environmental neurotoxin identified in the pulp of several fruits of the Annonaceae family, whose consumption was linked to the occurrence of sporadic atypical Parkinsonism with dementia. A method for its quantification in Rat brain homogenates by UPLC-MS/MS in selected reaction monitoring (SRM) mode was developed and validated. This method was applied to the quantitation of annonacin in Rat brain after intravenous (0.5 mg/kg) and oral (10 mg/kg, 100 mg/kg) administration.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Acetogenin; Annonaceae; Annonacin; Distribution; Rat brain; UPLC-MS/MS

Mesh：

Substances：

Year:  2016        PMID： 27058514     DOI： 10.1016/j.toxicon.2016.03.015

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  3 in total

1.  DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives.

Authors:  Fernanda Neumann; Stéphanie Gourdain; Christelle Albac; Alain D Dekker; Linh Chi Bui; Julien Dairou; Isabelle Schmitz-Afonso; Nathalie Hue; Fernando Rodrigues-Lima; Jean M Delabar; Marie-Claude Potier; Jean-Pierre Le Caër; David Touboul; Benoît Delatour; Kevin Cariou; Robert H Dodd
Journal:  Sci Rep       Date:  2018-02-12       Impact factor: 4.379

2.  Validation data for the quantification of the Annonaceous acetogenin annonacin in Rat brain by UPLC-MS/MS.

Authors:  Natacha Bonneau; Isabelle Schmitz-Afonso; Alain Brunelle; David Touboul; Pierre Champy
Journal:  Data Brief       Date:  2016-05-04

3.  Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells.

Authors:  Jee Young Kim; Thien T P Dao; Kwangho Song; Sait Byul Park; Hyeri Jang; Min Kyoung Park; Soo Ueng Gan; Yeong Shik Kim
Journal:  Evid Based Complement Alternat Med       Date:  2018-07-17       Impact factor: 2.629
  3 in total

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