Cristina Fortes1, Simona Mastroeni, Marjorie Segatto M, Clarissa Hohmann, Lucia Miligi, Lucio Bakos, Renan Bonamigo. 1. Epidemiology Unit, Istituto Dermopatico dell'Immacolata, IDI- IRCCS-FLMM, Rome, Italy (Fortes, Mastroeni); Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Brazil (Segatto M, Hohmann B, Bonamigo); Occupational and Environmental Epidemiology Unit, ISPO Cancer Prevention and Research, Institute, Florence, Italy (Miligi); Dermatology Service, Federal University of Health Sciences of Porto Alegre (Bonamigo); and Dermatology Service, Federal University of Rio Grande do Sul, Porto Alegre, Brazil (Bakos).
Abstract
OBJECTIVE: The objective of the study was to examine the association between occupational exposure to pesticides and cutaneous melanoma, controlling for all possible confounders. METHODS: A pooled analysis of two case-control studies was conducted in two different geographic areas (Italy and Brazil). Detailed pesticides exposure histories were obtained. RESULTS: Ever use of any pesticide was associated with a high risk of cutaneous melanoma (odds ratio 2.58; 95% confidence interval 1.18-5.65) in particular exposure to herbicides (glyphosate) and fungicides (mancozeb, maneb), after controlling for confounding factors. When subjects were exposed to both pesticides and occupational sun exposure, the risk increased even more (odds ratio 4.68; 95% confidence interval 1.29-17.0). CONCLUSIONS: The study suggests an augmented risk of cutaneous melanoma among subjects with exposure to pesticides, in particular among those exposed to occupational sun exposure.
OBJECTIVE: The objective of the study was to examine the association between occupational exposure to pesticides and cutaneous melanoma, controlling for all possible confounders. METHODS: A pooled analysis of two case-control studies was conducted in two different geographic areas (Italy and Brazil). Detailed pesticides exposure histories were obtained. RESULTS: Ever use of any pesticide was associated with a high risk of cutaneous melanoma (odds ratio 2.58; 95% confidence interval 1.18-5.65) in particular exposure to herbicides (glyphosate) and fungicides (mancozeb, maneb), after controlling for confounding factors. When subjects were exposed to both pesticides and occupational sun exposure, the risk increased even more (odds ratio 4.68; 95% confidence interval 1.29-17.0). CONCLUSIONS: The study suggests an augmented risk of cutaneous melanoma among subjects with exposure to pesticides, in particular among those exposed to occupational sun exposure.
Authors: Ildefonso Rodriguez-Leyva; Erika Chi-Ahumada; Manuel Mejía; Juan P Castanedo-Cazares; William Eng; Sami K Saikaly; Juan Carrizales; Todd D Levine; Robert A Norman; Maria E Jimenez-Capdeville Journal: Mov Disord Clin Pract Date: 2017-06-01