Makarios Eleftheriades1,2, Homeira Vafaei3, Ismene Dontas4, George Vaggos5, Katerina Marinou6, Panagiota Pervanidou7, Neil J Sebire8, George P Chrousos2,7, Kypros H Nicolaides9. 1. Embryocare, Fetal Medicine Unit, Athens, Greece. 2. First Department of Pediatrics, University of Athens School of Medicine, Aghia Sophia Children's Hospital, Athens, Greece. 3. Department of Obstetrics and Gynecology, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Laboratory for Research of the Musculoskeletal System, School of Medicine, University of Athens, Athens, Greece. 5. Department of Obstetrics and Gynecology, General Hospital of Arta, Arta, Greece. 6. Greek Ministry of Reconstruction of Production, Environment and Energy, Division of Animal Welfare, Athens, Greece. 7. Childhood Obesity Clinic, First Department of Pediatrics, University of Athens, School of Medicine, Aghia Sophia Children's Hospital, Athens, Greece. 8. Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, UK and UCL Institute of Child Health, London, UK. 9. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Abstract
BACKGROUND: This experimental study aims to investigate the impact of combinations of prenatal and postnatal food manipulation on body composition in rat offspring. METHODS: On day 12 of gestation, 100 timed pregnant rats were randomized into two nutritional groups: standard laboratory and 50% starved. Pups born to starved mothers were subdivided, based on birthweight (BiW), into fetal growth restricted (FGR) and non-FGR. Pups were born on day 21, cross-fostered, then left undisturbed lactating until the 26th postnatal day when they underwent dual-energy X-ray absorptiometry (DXA) examination. RESULTS: Prenatally control-fed animals had a significantly greater body weight at 26 d postnatally than the prenatally starved groups, irrespective of their postnatal diet (P < 0.001). Postnatal control diet was associated with significantly increased abdominal and total fat in non-FGR compared to FGR rats (P < 0.001). non-FGR/CONTROL rats showed higher values of abdominal fat than prenatally starved animals that were starved postnatally irrespective of their birth weight (P < 0.001). Postnatal control diet significantly increased total bone mineral content (BMC), head BMC, head area, abdominal BMC in non-FGR compared to FGR rats (P < 0.001). CONCLUSION: Interaction between prenatal and postnatal nutrition affects growth, abdominal adiposity, and bone accrual in Wistar rats' offspring at 26 d of life.
BACKGROUND: This experimental study aims to investigate the impact of combinations of prenatal and postnatal food manipulation on body composition in rat offspring. METHODS: On day 12 of gestation, 100 timed pregnant rats were randomized into two nutritional groups: standard laboratory and 50% starved. Pups born to starved mothers were subdivided, based on birthweight (BiW), into fetal growth restricted (FGR) and non-FGR. Pups were born on day 21, cross-fostered, then left undisturbed lactating until the 26th postnatal day when they underwent dual-energy X-ray absorptiometry (DXA) examination. RESULTS: Prenatally control-fed animals had a significantly greater body weight at 26 d postnatally than the prenatally starved groups, irrespective of their postnatal diet (P < 0.001). Postnatal control diet was associated with significantly increased abdominal and total fat in non-FGR compared to FGR rats (P < 0.001). non-FGR/CONTROL rats showed higher values of abdominal fat than prenatally starved animals that were starved postnatally irrespective of their birth weight (P < 0.001). Postnatal control diet significantly increased total bone mineral content (BMC), head BMC, head area, abdominal BMC in non-FGR compared to FGR rats (P < 0.001). CONCLUSION: Interaction between prenatal and postnatal nutrition affects growth, abdominal adiposity, and bone accrual in Wistar rats' offspring at 26 d of life.
Authors: James P Lister; Gene J Blatt; Thomas L Kemper; John Tonkiss; William A DeBassio; Janina R Galler; Douglas L Rosene Journal: Nutr Neurosci Date: 2011-07 Impact factor: 4.994
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Authors: Mette Tanvig; Christina A Vinter; Jan S Jørgensen; Sonja Wehberg; Per G Ovesen; Ronald F Lamont; Henning Beck-Nielsen; Henrik T Christesen; Dorte M Jensen Journal: PLoS One Date: 2014-02-24 Impact factor: 3.240