Carsten Müller1,2, Konstantin A Krauth3, Joachim Gerß4, Dieter Rosenbaum5. 1. Institute of Sports Science, Work Unit Human Performance and Training in Sports, University of Münster, Horstmarer Landweg 62b, 48149, Münster, Germany. c.mueller@uni-muenster.de. 2. Institute of Experimental Musculoskeletal Medicine, Movement Analysis Laboratory, University Hospital Münster, Domagkstr. 3, 48149, Münster, Germany. c.mueller@uni-muenster.de. 3. Klinik Bad Oexen, Kinderhaus, Oexen 27, 32549, Bad Oeynhausen, Germany. 4. Institute of Biostatistics and Clinical Research, University of Münster, Schmeddingstr. 56, 48149, Münster, Germany. 5. Institute of Experimental Musculoskeletal Medicine, Movement Analysis Laboratory, University Hospital Münster, Domagkstr. 3, 48149, Münster, Germany.
Abstract
PURPOSE: Chronic health conditions and impaired quality of life are commonly experienced in childhood cancer survivors. While rehabilitation clinics support patients in coping with the disease, studies evaluating an inpatient rehabilitation program on promoting physical activity (PA) and health-related quality of life (HRQoL) are missing. METHODS: A 4-week inpatient rehabilitation program was prospectively evaluated. One hundred fifty patients with leukemia or lymphoma (N = 86), brain tumors (N = 38), and sarcomas (N = 26) were enrolled on average 17 months after cessation of acute medical treatment. PA amount and cadence (indicating the intensity of walking activity) using the StepWatch™ 3 Activity Monitor and HRQoL global and physical well-being scores using the KINDL(®) questionnaire were assessed before, immediately after, and 6 and 12 months following the program and analyzed using multiple linear mixed models. RESULTS: Significant effects on PA were only found at 12-month follow-up for amount and cadence variables (all p < 0.05). While leukemia and lymphoma patients revealed the highest PA level throughout the study, rehabilitation effects were more pronounced for cadence variables in brain tumor and sarcoma patients. The rehabilitation program had immediate (t = 4.56, p < 0.001) and sustainable effects on HRQoL global scores (6-month follow-up, t = 4.08, p < 0.001; 12-month follow-up, t = 3.13, p < 0.006). CONCLUSIONS: Immediate and sustainable increases in HRQoL indicate that a 4-week rehabilitation program is beneficial for improving psychosocial well-being, while the significant increase in PA levels could be related to general recovery as well. The lack of a control group hampers the evaluation of the rehabilitation program on promoting PA levels in pediatric cancer patients.
PURPOSE: Chronic health conditions and impaired quality of life are commonly experienced in childhood cancer survivors. While rehabilitation clinics support patients in coping with the disease, studies evaluating an inpatient rehabilitation program on promoting physical activity (PA) and health-related quality of life (HRQoL) are missing. METHODS: A 4-week inpatient rehabilitation program was prospectively evaluated. One hundred fifty patients with leukemia or lymphoma (N = 86), brain tumors (N = 38), and sarcomas (N = 26) were enrolled on average 17 months after cessation of acute medical treatment. PA amount and cadence (indicating the intensity of walking activity) using the StepWatch™ 3 Activity Monitor and HRQoL global and physical well-being scores using the KINDL(®) questionnaire were assessed before, immediately after, and 6 and 12 months following the program and analyzed using multiple linear mixed models. RESULTS: Significant effects on PA were only found at 12-month follow-up for amount and cadence variables (all p < 0.05). While leukemia and lymphomapatients revealed the highest PA level throughout the study, rehabilitation effects were more pronounced for cadence variables in brain tumor and sarcomapatients. The rehabilitation program had immediate (t = 4.56, p < 0.001) and sustainable effects on HRQoL global scores (6-month follow-up, t = 4.08, p < 0.001; 12-month follow-up, t = 3.13, p < 0.006). CONCLUSIONS: Immediate and sustainable increases in HRQoL indicate that a 4-week rehabilitation program is beneficial for improving psychosocial well-being, while the significant increase in PA levels could be related to general recovery as well. The lack of a control group hampers the evaluation of the rehabilitation program on promoting PA levels in pediatric cancerpatients.
Authors: C Rossig; H Juergens; M Schrappe; A Moericke; G Henze; A von Stackelberg; D Reinhardt; B Burkhardt; W Woessmann; M Zimmermann; H Gadner; G Mann; G Schellong; C Mauz-Koerholz; U Dirksen; S Bielack; F Berthold; N Graf; S Rutkowski; G Calaminus; P Kaatsch; U Creutzig Journal: Pediatr Blood Cancer Date: 2013-06-05 Impact factor: 3.167
Authors: Raheem J Paxton; Lee W Jones; Philip M Rosoff; Melanie Bonner; Joann L Ater; Wendy Demark-Wahnefried Journal: Psychooncology Date: 2010-09 Impact factor: 3.894
Authors: Eric J Chow; Kasey J Leger; Neel S Bhatt; Daniel A Mulrooney; Colin J Ross; Sanjeev Aggarwal; Neha Bansal; Matthew J Ehrhardt; Saro H Armenian; Jessica M Scott; Borah Hong Journal: Cardiovasc Res Date: 2019-04-15 Impact factor: 10.787
Authors: Mary C Hooke; Michelle A Mathiason; Audrey Blommer; Jessica Hutter; Pauline Mitby; Olga Taylor; Michael E Scheurer; Alicia S Kunin-Batson; Wei Pan; Marilyn J Hockenberry Journal: Cancer Nurs Date: 2022 Mar-Apr 01 Impact factor: 2.592
Authors: Brooke E Kohler; Carolina X Sandler; Emmah Baque; Natalie K Bradford; Stewart G Trost Journal: Front Pediatr Date: 2022-09-16 Impact factor: 3.569
Authors: Paula A Ospina; Alyssa McComb; Lesley E Pritchard-Wiart; David D Eisenstat; Margaret L McNeely Journal: Cochrane Database Syst Rev Date: 2021-08-03