Mary C Hooke1, Michelle A Mathiason, Audrey Blommer, Jessica Hutter, Pauline Mitby, Olga Taylor, Michael E Scheurer, Alicia S Kunin-Batson, Wei Pan, Marilyn J Hockenberry. 1. Author Affiliations: Schools of Nursing (Dr Hooke and Ms Mathiason) and Medicine (Dr Kunin-Batson), University of Minnesota, Minneapolis; Children's Minnesota Cancer and Blood Disorders Program (Mss Blommer, Hutter, and Mitby and Dr Hooke), Minneapolis; Texas Children's Cancer and Hematology Centers/Baylor College of Medicine, Houston (Ms Taylor and Drs Scheurer and Hockenberry); and Schools of Nursing (Dr Pan) and Medicine (Dr Pan), Duke University, Durham, North Carolina.
Abstract
BACKGROUND: Children undergoing treatment for acute lymphocytic leukemia (ALL) report co-occurring symptoms of fatigue, sleep disturbances, and depression as a symptom cluster. Physical activity (PA) may influence symptom severity and quality of life (QOL). OBJECTIVES: This study examined changes in symptoms and QOL during ALL maintenance in children categorized by symptom cluster and explored the influence of PA and symptoms on QOL. METHODS: Self-report of fatigue, sleep disturbance, and depression; QOL; and PA were measured at the beginning and end of maintenance in 42 children aged 3 to 18 years with ALL. Children were categorized into symptom cluster groups based on measurements at the beginning of maintenance. RESULTS: Two latent classes of symptom clusters (low and high) were identified with significant differences between groups in symptoms at both the beginning and end maintenance (P < .01). Each group's symptom levels did not change during maintenance. Quality-of-life was different between groups at both time points (P < .01) and did not improve. Children with low symptoms and high PA at the beginning of maintenance had better QOL as treatment ended compared with the physically active high-symptom group and the inactive high-symptom group (P < .01). CONCLUSIONS: Children with higher symptoms did not experience an improvement with time. Symptom and PA levels may influence QOL at the end of treatment. IMPLICATIONS FOR PRACTICE: Maintenance therapy is a long time (1.5 years) in a child's life. Symptom assessment is needed early in maintenance; interventions are needed for children with high levels.
BACKGROUND: Children undergoing treatment for acute lymphocytic leukemia (ALL) report co-occurring symptoms of fatigue, sleep disturbances, and depression as a symptom cluster. Physical activity (PA) may influence symptom severity and quality of life (QOL). OBJECTIVES: This study examined changes in symptoms and QOL during ALL maintenance in children categorized by symptom cluster and explored the influence of PA and symptoms on QOL. METHODS: Self-report of fatigue, sleep disturbance, and depression; QOL; and PA were measured at the beginning and end of maintenance in 42 children aged 3 to 18 years with ALL. Children were categorized into symptom cluster groups based on measurements at the beginning of maintenance. RESULTS: Two latent classes of symptom clusters (low and high) were identified with significant differences between groups in symptoms at both the beginning and end maintenance (P < .01). Each group's symptom levels did not change during maintenance. Quality-of-life was different between groups at both time points (P < .01) and did not improve. Children with low symptoms and high PA at the beginning of maintenance had better QOL as treatment ended compared with the physically active high-symptom group and the inactive high-symptom group (P < .01). CONCLUSIONS: Children with higher symptoms did not experience an improvement with time. Symptom and PA levels may influence QOL at the end of treatment. IMPLICATIONS FOR PRACTICE: Maintenance therapy is a long time (1.5 years) in a child's life. Symptom assessment is needed early in maintenance; interventions are needed for children with high levels.
Authors: Lillian Sung; Rochelle Yanofsky; Robert J Klaassen; David Dix; Sheila Pritchard; Naomi Winick; Sarah Alexander; Anne Klassen Journal: Int J Cancer Date: 2011-03-01 Impact factor: 7.396
Authors: Pamela S Hinds; Jie Yang; Jami S Gattuso; Marilyn Hockenberry; Heather Jones; Sue Zupanec; Chenghong Li; Valerie McLaughlin Crabtree; Belinda N Mandrell; Robert A Schoumacher; Kelly Vallance; Stacy Sanford; Deo Kumar Srivastava Journal: J Pain Symptom Manage Date: 2010-03 Impact factor: 3.612
Authors: Marilyn J Hockenberry; Olga A Taylor; Alice Pasvogel; Cheryl Rodgers; Kathy McCarthy; Patricia Gundy; David W Montgomery; Phillip Ribbeck; Michael E Scheurer; Ida M Ki Moore Journal: Oncol Nurs Forum Date: 2014-07-01 Impact factor: 2.172
Authors: Marilyn J Hockenberry; Mary C Hooke; Maryann Gregurich; Kathy McCarthy; Gennaro Sambuco; Kevin Krull Journal: Oncol Nurs Forum Date: 2010-01 Impact factor: 2.172