Literature DB >> 27053183

GeneXpert for Diagnosis of Tubercular Meningitis.

Rakesh Bhatia1, Rajeshwar Dayal1, Shishir Jindal1, Dipti Agarwal2,3, Ankur Goyal4.   

Abstract

Diagnosis of tubercular meningitis (TBM) is difficult in children. The GeneXpert MTB/RIF assay has been recommended by WHO in 2013 to be used in children and in extra pulmonary clinical specimens. The present study was designed to assess the diagnostic utility of GeneXpert in detecting Mycobacterium tuberculosis in cerebrospinal fluid (CSF) in TBM cases and to compare the results with liquid culture BACTEC 460. Thirty four subjects <15 y were diagnosed as TBM based on clinical, CSF and imaging details. Sensitivity of GeneXpert in CSF was 38.24 % as compared to Bactec culture which was only 14.71 % (p 0.0279). To conclude, GeneXpert MTB/RIF test is able to rapidly confirm diagnosis of TBM with higher sensitivity as compared to conventional methods and liquid culture.

Entities:  

Keywords:  BACTEC; Cerebrospinal fluid; Diagnosis; GeneXpert; Tubercular meningitis

Mesh：

Year:  2016        PMID： 27053183     DOI： 10.1007/s12098-016-2096-0

Source DB:  PubMed          Journal:  Indian J Pediatr        ISSN： 0019-5456            Impact factor:   1.967


  7 in total

1.  A comparative study for the detection of Mycobacteria by BACTEC MGIT 960, Lowenstein Jensen media and direct AFB smear examination.

Authors:  S Rishi; P Sinha; B Malhotra; N Pal
Journal:  Indian J Med Microbiol       Date:  2007-10       Impact factor: 0.985

2.  Xpert MTB/RIF: a new pillar in diagnosis of extrapulmonary tuberculosis?

Authors:  Viral Vadwai; Catharina Boehme; Pamela Nabeta; Anjali Shetty; David Alland; Camilla Rodrigues
Journal:  J Clin Microbiol       Date:  2011-05-18       Impact factor: 5.948

3.  CT of the brain in tuberculous meningitis. A review of 289 patients.

Authors:  M Ozateş; S Kemaloglu; F Gürkan; U Ozkan; S Hoşoglu; M M Simşek
Journal:  Acta Radiol       Date:  2000-01       Impact factor: 1.990

4.  Tuberculosis of the central nervous system in children: a 20-year survey.

Authors:  N J Farinha; K A Razali; H Holzel; G Morgan; V M Novelli
Journal:  J Infect       Date:  2000-07       Impact factor: 6.072

Review 5.  Clinical manifestations of tuberculosis in children.

Authors:  Andrea T Cruz; Jeffrey R Starke
Journal:  Paediatr Respir Rev       Date:  2007-06-05       Impact factor: 2.726

6.  Rapid Diagnosis of Pulmonary and Extrapulmonary Tuberculosis in HIV-Infected Patients. Comparison of LED Fluorescent Microscopy and the GeneXpert MTB/RIF Assay in a District Hospital in India.

Authors:  Gerardo Alvarez-Uria; Jose M Azcona; Manoranjan Midde; Praveen K Naik; Srinivasulu Reddy; Raghuprakash Reddy
Journal:  Tuberc Res Treat       Date:  2012-08-26

7.  Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis.

Authors:  Nguyen Thi Quynh Nhu; Dorothee Heemskerk; Do Dang Anh Thu; Tran Thi Hong Chau; Nguyen Thi Hoang Mai; Ho Dang Trung Nghia; Pham Phu Loc; Dang Thi Minh Ha; Laura Merson; Tran Thi Van Thinh; Jeremy Day; Nguyen van Vinh Chau; Marcel Wolbers; Jeremy Farrar; Maxine Caws
Journal:  J Clin Microbiol       Date:  2013-11-06       Impact factor: 5.948
  7 in total
  9 in total

1.  Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults.

Authors:  Mikashmi Kohli; Ian Schiller; Nandini Dendukuri; Mandy Yao; Keertan Dheda; Claudia M Denkinger; Samuel G Schumacher; Karen R Steingart
Journal:  Cochrane Database Syst Rev       Date:  2021-01-15

2.  The Utility of CSF Xpert MTB/RIF in Diagnosis of Tubercular Meningitis in Children.

Authors:  Jyothy A; Vinod H Ratageri; Shivanand Illalu; S R Fattepur; P K Wari
Journal:  Indian J Pediatr       Date:  2019-07-19       Impact factor: 1.967

3.  A Case of Brain Tuberculosis With an Unusual Presentation Mimicking Viral Fever During a Dengue Outbreak in Bangladesh.

Authors:  Muhammad Rezeul Huq; M A Hannan; Shahida Bulbul; Anis Ahmed; Ahad Mahmud Khan
Journal:  Cureus       Date:  2022-01-15

Review 4.  Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance.

Authors:  Mikashmi Kohli; Ian Schiller; Nandini Dendukuri; Keertan Dheda; Claudia M Denkinger; Samuel G Schumacher; Karen R Steingart
Journal:  Cochrane Database Syst Rev       Date:  2018-08-27

Review 5.  Microbiological diagnosis of tuberculous meningitis: Phenotype to genotype.

Authors:  Ravindra Kumar Garg
Journal:  Indian J Med Res       Date:  2019-11       Impact factor: 2.375

6.  Clinical Profile, Yield of Cartridge-based Nucleic Acid Amplification Test (GeneXpert), and Outcome in Children with Tubercular Meningitis.

Authors:  Santosh K Soma; Lokesh Lingappa; Subodh Raju; Ramesh Konanki; Amit K Gaur; Ashwini Mohan; Smilu Mohanlal
Journal:  J Pediatr Neurosci       Date:  2020-11-06

7.  Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children.

Authors:  Alexander W Kay; Lucia González Fernández; Yemisi Takwoingi; Michael Eisenhut; Anne K Detjen; Karen R Steingart; Anna M Mandalakas
Journal:  Cochrane Database Syst Rev       Date:  2020-08-27

Review 8.  Tuberculous meningitis in children: Clinical management & outcome.

Authors:  Bella Devaleenal Daniel; G Angeline Grace; Mohan Natrajan
Journal:  Indian J Med Res       Date:  2019-08       Impact factor: 2.375

9.  Cerebrospinal fluid Gene XPERT (CBNAAT) in children with tuberculous meningitis.

Authors:  Annapurna Rai; Rajniti Prasad; B K Das; Shampa Anupurba; Utpal Kant Singh
Journal:  J Clin Tuberc Other Mycobact Dis       Date:  2021-06-24
  9 in total

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