Nora F Dengler1, Vince I Madai2, Jens Wuerfel3, Federico C von Samson-Himmelstjerna4, Petr Dusek5, Thoralf Niendorf6, Jan Sobesky2, Peter Vajkoczy7. 1. Department of Neurosurgery, Charité Universitätsmedizin Berlin, Berlin, Germany. 2. Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany; Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany. 3. Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany; Neurocure Clinical Research Centre, Charité Universitätsmedizin Berlin, Berlin, Germany; Institute of Neuroradiology, University Göttingen, Göttingen, Germany; Berlin Ultra-High Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; Medical Image Analysis Center (MIAC AG), Basel, Switzerland. 4. Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany. 5. Institute of Neuroradiology, University Göttingen, Göttingen, Germany; Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Praha, Czech Republic. 6. Berlin Ultra-High Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany. 7. Department of Neurosurgery, Charité Universitätsmedizin Berlin, Berlin, Germany. Electronic address: peter.vajkoczy@charite.de.
Abstract
BACKGROUND: Prompt diagnosis of vessel pathology and appropriate treatment of moyamoya vasculopathy (MMV) are essential to improve long-term prognosis. The aims of our study were to explore the diagnostic value of ultra-high-field (UHF) magnetic resonance imaging at 7.0 T in MMV patients and to compare the applicability of two different 7.0 T vessel imaging modalities to 3.0 T magnetic resonance angiography (MRA) and digital subtraction angiography (DSA). METHODS: In a World Health Organization-registered and prospective imaging trial, patients were investigated at 7.0 T magnetization-prepared rapid-acquisition gradient echo (MPRAGE)-MRA and time-of-flight (TOF)-MRA, 3.0 T TOF-MRA, and by DSA. RESULTS: Six patients were included in our study and evaluated for MMV. 3.0 T TOF-MRA and 7.0 T MPRAGE-MRA were able to depict the complete major vascular tree and confirmed MMV-specific steno-occlusions of major intracranial arteries, as previously identified by DSA. 7.0 T TOF-MRA was limited to visualization of the circle of Willis as well as the internal carotid artery only. Donor vessels for bypass surgery (i.e., branches of superficial temporal artery) could be sufficiently visualized with all magnetic resonance modalities. CONCLUSIONS: Our results indicate that a specific 7.0 T vascular imaging protocol yields diagnostic information about vessel pathology in MMV that approximates conventional DSA. 7.0 T MPRAGE was superior to 7.0 T TOF-MRA due to shorter scanning times and better brain coverage. To date, however, limited availability of 7.0 T technology in medical facilities as well as technical and procedural constraints excludes a fair amount of patients from the clinical 7.0 T imaging process.
BACKGROUND: Prompt diagnosis of vessel pathology and appropriate treatment of moyamoya vasculopathy (MMV) are essential to improve long-term prognosis. The aims of our study were to explore the diagnostic value of ultra-high-field (UHF) magnetic resonance imaging at 7.0 T in MMV patients and to compare the applicability of two different 7.0 T vessel imaging modalities to 3.0 T magnetic resonance angiography (MRA) and digital subtraction angiography (DSA). METHODS: In a World Health Organization-registered and prospective imaging trial, patients were investigated at 7.0 T magnetization-prepared rapid-acquisition gradient echo (MPRAGE)-MRA and time-of-flight (TOF)-MRA, 3.0 T TOF-MRA, and by DSA. RESULTS: Six patients were included in our study and evaluated for MMV. 3.0 T TOF-MRA and 7.0 T MPRAGE-MRA were able to depict the complete major vascular tree and confirmed MMV-specific steno-occlusions of major intracranial arteries, as previously identified by DSA. 7.0 T TOF-MRA was limited to visualization of the circle of Willis as well as the internal carotid artery only. Donor vessels for bypass surgery (i.e., branches of superficial temporal artery) could be sufficiently visualized with all magnetic resonance modalities. CONCLUSIONS: Our results indicate that a specific 7.0 T vascular imaging protocol yields diagnostic information about vessel pathology in MMV that approximates conventional DSA. 7.0 T MPRAGE was superior to 7.0 T TOF-MRA due to shorter scanning times and better brain coverage. To date, however, limited availability of 7.0 T technology in medical facilities as well as technical and procedural constraints excludes a fair amount of patients from the clinical 7.0 T imaging process.
Authors: T Matsushige; M Kraemer; T Sato; P Berlit; M Forsting; M E Ladd; R Jabbarli; U Sure; N Khan; M Schlamann; K H Wrede Journal: AJNR Am J Neuroradiol Date: 2018-06-07 Impact factor: 3.825
Authors: Laurens Jl De Cocker; Arjen Lindenholz; Jaco Jm Zwanenburg; Anja G van der Kolk; Maarten Zwartbol; Peter R Luijten; Jeroen Hendrikse Journal: Neuroimage Date: 2016-11-18 Impact factor: 6.556
Authors: Adam Hilbert; Vince I Madai; Ela M Akay; Orhun U Aydin; Jonas Behland; Jan Sobesky; Ivana Galinovic; Ahmed A Khalil; Abdel A Taha; Jens Wuerfel; Petr Dusek; Thoralf Niendorf; Jochen B Fiebach; Dietmar Frey; Michelle Livne Journal: Front Artif Intell Date: 2020-09-25