| Literature DB >> 27049705 |
Isis Regina Grenier Capoci1, Michele Milano da Cunha1, Patricia de Souza Bonfim-Mendonça1, Luciana Dias Ghiraldi-Lopes1, Lilian Cristiane Baeza1, Erika Seki Kioshima1, Terezinha Inez Estivalet Svidzinski1.
Abstract
Dermatophytosis is a common zoonosis in urban centers. Dogs and cats have played an important role as its disseminators. Environmental decontamination is essential for the prevention of its propagation to humans and animals. However, sanitizers or disinfectants with antifungal activity, currently available, have high toxicity. The present study evaluated the in vitro effects of an extract of citronella (Cymbopogon nardus) on 31 Microsporum canis isolates from animals and home environments. Susceptibility tests were performed based on document M38-A2 (2008) of the Clinical and Laboratory Standards Institute with modifications for natural products. Although susceptibility variation was observed between the fungus tested, the concentrations that inhibited the growth of 50 and 90% of the microorganisms were low (19.5 and 78 µg/mL, respectively). Thus, this citronella extract showed potent fungistatic and fungicide activities against M. canis isolated from animals and home environments. Therefore, it could be an alternative for dermatophytosis prophylaxis in the home environment.Entities:
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Year: 2015 PMID: 27049705 PMCID: PMC4727137 DOI: 10.1590/S0036-46652015000600008
Source DB: PubMed Journal: Rev Inst Med Trop Sao Paulo ISSN: 0036-4665 Impact factor: 1.846