A K Gupta1, W Brintnell. 1. University of Toronto, Division of Dermatology, Department of Medicine.
Abstract
BACKGROUND: Ozone gas possesses antimicrobial potential against many microorganisms, however limited data exist on its effect on the keratinophilic dermatophyte fungi Trichophyton rubrum and Trichophyton mentagrophytes; two organisms commonly isolated as the etiological agent in onychomycosis and tinea pedis patients. OBJECTIVE/ METHODS: We utilized a commercial ozone gas generation device for testing the fungicidal effects of ozone on ATCC strains of Trichophyton rubrum and Trichophyton mentagrophytes. RESULTS: We demonstrated that ozone gas is effective in killing > 99% of viable fungi present in various experimental systems. CONCLUSION: This work represents a proof of principle regarding ozone gas and its fungicidal effect on dermatophyte fungi. From these findings, further ozone gas studies will be conducted to develop a novel adjunct therapy for use in parallel with current antifungal medications and/or devices to better treat onychomycosis and tinea pedis patients in the short and long term.
BACKGROUND: Ozone gas possesses antimicrobial potential against many microorganisms, however limited data exist on its effect on the keratinophilic dermatophyte fungi Trichophyton rubrum and Trichophyton mentagrophytes; two organisms commonly isolated as the etiological agent in onychomycosis and tinea pedispatients. OBJECTIVE/ METHODS: We utilized a commercial ozone gas generation device for testing the fungicidal effects of ozone on ATCC strains of Trichophyton rubrum and Trichophyton mentagrophytes. RESULTS: We demonstrated that ozone gas is effective in killing > 99% of viable fungi present in various experimental systems. CONCLUSION: This work represents a proof of principle regarding ozone gas and its fungicidal effect on dermatophyte fungi. From these findings, further ozone gas studies will be conducted to develop a novel adjunct therapy for use in parallel with current antifungal medications and/or devices to better treat onychomycosis and tinea pedispatients in the short and long term.
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