Literature DB >> 27045444

An alerting structure: human orexin receptor 1.

Daniel Wacker1, Bryan L Roth1,2.   

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Year:  2016        PMID： 27045444     DOI： 10.1038/nsmb.3198

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


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  18 in total

Review 1.  Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia.

Authors:  Anthony J Roecker; Christopher D Cox; Paul J Coleman
Journal:  J Med Chem       Date:  2015-09-15       Impact factor: 7.446

2.  Abnormal sleep/wake dynamics in orexin knockout mice.

Authors:  Cecilia G Diniz Behn; Elizabeth B Klerman; Takatoshi Mochizuki; Shih-Chieh Lin; Thomas E Scammell
Journal:  Sleep       Date:  2010-03       Impact factor: 5.849

Review 3.  The hypocretins/orexins: integrators of multiple physiological functions.

Authors:  Jingcheng Li; Zhian Hu; Luis de Lecea
Journal:  Br J Pharmacol       Date:  2014-01       Impact factor: 8.739

4.  Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.

Authors:  Emi Hasegawa; Masashi Yanagisawa; Takeshi Sakurai; Michihiro Mieda
Journal:  J Clin Invest       Date:  2014-01-02       Impact factor: 14.808

5.  Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.

Authors:  Jie Yin; Juan Carlos Mobarec; Peter Kolb; Daniel M Rosenbaum
Journal:  Nature       Date:  2014-12-22       Impact factor: 49.962

6.  Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Authors:  T Sakurai; A Amemiya; M Ishii; I Matsuzaki; R M Chemelli; H Tanaka; S C Williams; J A Richardson; G P Kozlowski; S Wilson; J R Arch; R E Buckingham; A C Haynes; S A Carr; R S Annan; D E McNulty; W S Liu; J A Terrett; N A Elshourbagy; D J Bergsma; M Yanagisawa
Journal:  Cell       Date:  1998-02-20       Impact factor: 41.582

7.  Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist.

Authors:  Michel A Steiner; John Gatfield; Catherine Brisbare-Roch; Hendrik Dietrich; Alexander Treiber; Francois Jenck; Christoph Boss
Journal:  ChemMedChem       Date:  2013-04-15       Impact factor: 3.466

Review 8.  The role of hypocretin in driving arousal and goal-oriented behaviors.

Authors:  Benjamin Boutrel; Nazzareno Cannella; Luis de Lecea
Journal:  Brain Res       Date:  2009-11-27       Impact factor: 3.252

9.  Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.

Authors:  Miles Congreve; Stephen P Andrews; Andrew S Doré; Kaspar Hollenstein; Edward Hurrell; Christopher J Langmead; Jonathan S Mason; Irene W Ng; Benjamin Tehan; Andrei Zhukov; Malcolm Weir; Fiona H Marshall
Journal:  J Med Chem       Date:  2012-01-27       Impact factor: 7.446

10.  LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy.

Authors:  Thomas E Fitch; Mark J Benvenga; Cynthia D Jesudason; Charity Zink; Amy B Vandergriff; Michelle M Menezes; Douglas A Schober; Linda M Rorick-Kehn
Journal:  Front Neurosci       Date:  2014-01-28       Impact factor: 4.677
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  2 in total

Review 1.  The Orexin receptors: Structural and anti-tumoral properties.

Authors:  Alain Couvineau; Pascal Nicole; Valérie Gratio; Thierry Voisin
Journal:  Front Endocrinol (Lausanne)       Date:  2022-07-28       Impact factor: 6.055

Review 2.  Insights From Molecular Dynamics Simulations of a Number of G-Protein Coupled Receptor Targets for the Treatment of Pain and Opioid Use Disorders.

Authors:  João Marcelo Lamim Ribeiro; Marta Filizola
Journal:  Front Mol Neurosci       Date:  2019-08-23       Impact factor: 5.639
  2 in total

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