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Literature DB >> 27045016

Molecular Mechanism of Mutant CALR-Mediated Transformation.

Abstract

Elf and colleagues used an elegant series of functional and biochemical assays to investigate the molecular mechanism of mutant calreticulin (CALR)-driven cellular transformation in myeloproliferative neoplasms (MPN). Mutant CALR is sufficient to induce MPN in mouse transplantation experiments, and transformation is dependent upon physical interaction mediated by the positive electrostatic charge of the mutant CALR C-terminal domain and the thrombopoietin receptor MPL. ©2016 American Association for Cancer Research.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Janus Kinase 2

Year: 2016 PMID： 27045016 PMCID： PMC4832981 DOI： 10.1158/2159-8290.CD-16-0238

Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397

9 in total

Review 1. Myeloproliferative Neoplasms: A Contemporary Review.

Authors: Ayalew Tefferi; Animesh Pardanani
Journal: JAMA Oncol Date: 2015-04 Impact factor: 31.777

2. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

Authors: G Q Daley; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1988-12 Impact factor: 11.205

3. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients.

Authors: Animesh D Pardanani; Ross L Levine; Terra Lasho; Yana Pikman; Ruben A Mesa; Martha Wadleigh; David P Steensma; Michelle A Elliott; Alexandra P Wolanskyj; William J Hogan; Rebecca F McClure; Mark R Litzow; D Gary Gilliland; Ayalew Tefferi
Journal: Blood Date: 2006-07-25 Impact factor: 22.113

4. Somatic mutations of calreticulin in myeloproliferative neoplasms.

Authors: Thorsten Klampfl; Heinz Gisslinger; Ashot S Harutyunyan; Harini Nivarthi; Elisa Rumi; Jelena D Milosevic; Nicole C C Them; Tiina Berg; Bettina Gisslinger; Daniela Pietra; Doris Chen; Gregory I Vladimer; Klaudia Bagienski; Chiara Milanesi; Ilaria Carola Casetti; Emanuela Sant'Antonio; Virginia Ferretti; Chiara Elena; Fiorella Schischlik; Ciara Cleary; Melanie Six; Martin Schalling; Andreas Schönegger; Christoph Bock; Luca Malcovati; Cristiana Pascutto; Giulio Superti-Furga; Mario Cazzola; Robert Kralovics
Journal: N Engl J Med Date: 2013-12-10 Impact factor: 91.245

5. Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.

Authors: Shannon Elf; Nouran S Abdelfattah; Edwin Chen; Javier Perales-Patón; Emily A Rosen; Amy Ko; Fabian Peisker; Natalie Florescu; Silvia Giannini; Ofir Wolach; Elizabeth A Morgan; Zuzana Tothova; Julie-Aurore Losman; Rebekka K Schneider; Fatima Al-Shahrour; Ann Mullally
Journal: Cancer Discov Date: 2016-03-07 Impact factor: 39.397

Review 6. Myeloproliferative neoplasms: A decade of discoveries and treatment advances.

Authors: Ayalew Tefferi
Journal: Am J Hematol Date: 2016-01 Impact factor: 10.047

7. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

Authors: Yana Pikman; Benjamin H Lee; Thomas Mercher; Elizabeth McDowell; Benjamin L Ebert; Maricel Gozo; Adam Cuker; Gerlinde Wernig; Sandra Moore; Ilene Galinsky; Daniel J DeAngelo; Jennifer J Clark; Stephanie J Lee; Todd R Golub; Martha Wadleigh; D Gary Gilliland; Ross L Levine
Journal: PLoS Med Date: 2006-07 Impact factor: 11.069

8. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.

Authors: J Nangalia; C E Massie; E J Baxter; F L Nice; G Gundem; D C Wedge; E Avezov; J Li; K Kollmann; D G Kent; A Aziz; A L Godfrey; J Hinton; I Martincorena; P Van Loo; A V Jones; P Guglielmelli; P Tarpey; H P Harding; J D Fitzpatrick; C T Goudie; C A Ortmann; S J Loughran; K Raine; D R Jones; A P Butler; J W Teague; S O'Meara; S McLaren; M Bianchi; Y Silber; D Dimitropoulou; D Bloxham; L Mudie; M Maddison; B Robinson; C Keohane; C Maclean; K Hill; K Orchard; S Tauro; M-Q Du; M Greaves; D Bowen; B J P Huntly; C N Harrison; N C P Cross; D Ron; A M Vannucchi; E Papaemmanuil; P J Campbell; A R Green
Journal: N Engl J Med Date: 2013-12-10 Impact factor: 91.245

Review 9. Functional roles of calreticulin in cancer biology.

Authors: Yi-Chien Lu; Wen-Chin Weng; Hsinyu Lee
Journal: Biomed Res Int Date: 2015-03-31 Impact factor: 3.411