Literature DB >> 27043322

State-of-the-Art Metabolic Toxicity Screening and Pathway Evaluation.

Eli G Hvastkovs1, James F Rusling2,3,4,5.   

Abstract

Routine in vitro bioassays and animal toxicity studies of drug and environmental chemical candidates fail to reveal toxicity in ∼30% of cases. This Feature article addresses research on new approaches to in vitro toxicity testing as well as our own efforts to produce high-throughput genotoxicity arrays and LC-MS/MS approaches to reveal possible chemical pathways of toxicity.

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Year:  2016        PMID： 27043322      PMCID： PMC4862375          DOI： 10.1021/acs.analchem.5b04772

Source DB:  PubMed          Journal:  Anal Chem        ISSN： 0003-2700            Impact factor:   6.986


  86 in total

1.  Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip.

Authors:  Megan L McCain; Sean P Sheehy; Anna Grosberg; Josue A Goss; Kevin Kit Parker
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-28       Impact factor: 11.205

2.  Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays?

Authors:  Sitta Sittampalam; Richard Eglen; Stephen Ferguson; Jason Thomas Maynes; Kenneth Olden; Laura Schrader; Todd Shelper; Marc Ferrer
Journal:  Assay Drug Dev Technol       Date:  2015-06-29       Impact factor: 1.738

Review 3.  Elucidating mechanisms of drug-induced toxicity.

Authors:  Daniel C Liebler; F Peter Guengerich
Journal:  Nat Rev Drug Discov       Date:  2005-05       Impact factor: 84.694

4.  Microfluidic electrochemical array for detection of reactive metabolites formed by cytochrome P450 enzymes.

Authors:  Dhanuka P Wasalathanthri; Vigneshwaran Mani; Chi K Tang; James F Rusling
Journal:  Anal Chem       Date:  2011-11-15       Impact factor: 6.986

5.  Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies.

Authors:  Katrin Zeilinger; Thomas Schreiter; Malin Darnell; Therese Söderdahl; Marc Lübberstedt; Birgitta Dillner; Daniel Knobeloch; Andreas K Nüssler; Jörg C Gerlach; Tommy B Andersson
Journal:  Tissue Eng Part C Methods       Date:  2011-02-16       Impact factor: 3.056

Review 6.  Organs-on-chips at the frontiers of drug discovery.

Authors:  Eric W Esch; Anthony Bahinski; Dongeun Huh
Journal:  Nat Rev Drug Discov       Date:  2015-03-20       Impact factor: 84.694

7.  Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites.

Authors:  Eli G Hvastkovs; Minjeong So; Sadagopan Krishnan; Besnik Bajrami; Maricar Tarun; Ingela Jansson; John B Schenkman; James F Rusling
Journal:  Anal Chem       Date:  2007-01-30       Impact factor: 6.986

Review 8.  Sensors for toxicity of chemicals and oxidative stress based on electrochemical catalytic DNA oxidation.

Authors:  James F Rusling
Journal:  Biosens Bioelectron       Date:  2004-11-15       Impact factor: 10.618

9.  A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.

Authors:  Dongeun Huh; Daniel C Leslie; Benjamin D Matthews; Jacob P Fraser; Samuel Jurek; Geraldine A Hamilton; Kevin S Thorneloe; Michael Allen McAlexander; Donald E Ingber
Journal:  Sci Transl Med       Date:  2012-11-07       Impact factor: 17.956

Review 10.  Cytochrome p450 and chemical toxicology.

Authors:  F Peter Guengerich
Journal:  Chem Res Toxicol       Date:  2007-12-06       Impact factor: 3.739
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  12 in total

1.  Evaluating Metabolite-Related DNA Oxidation and Adduct Damage from Aryl Amines Using a Microfluidic ECL Array.

Authors:  Itti Bist; Snehasis Bhakta; Di Jiang; Tia E Keyes; Aaron Martin; Robert J Forster; James F Rusling
Journal:  Anal Chem       Date:  2017-11-09       Impact factor: 6.986

Review 2.  New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development.

Authors:  Jonathon Parrish; Khoon Lim; Boyang Zhang; Milica Radisic; Tim B F Woodfield
Journal:  Trends Biotechnol       Date:  2019-06-12       Impact factor: 19.536

Review 3.  Recent advances in microfluidics for drug screening.

Authors:  Jiahui Sun; Antony R Warden; Xianting Ding
Journal:  Biomicrofluidics       Date:  2019-11-18       Impact factor: 2.800

4.  Modern Approaches to Chemical Toxicity Screening.

Authors:  Eli G Hvastkovs; James F Rusling
Journal:  Curr Opin Electrochem       Date:  2017-04-03

5.  Developing Microfluidic Sensing Devices Using 3D Printing.

Authors:  James F Rusling
Journal:  ACS Sens       Date:  2018-03-05       Impact factor: 7.711

6.  Automated 3-D Printed Arrays to Evaluate Genotoxic Chemistry: E-Cigarettes and Water Samples.

Authors:  Karteek Kadimisetty; Spundana Malla; James F Rusling
Journal:  ACS Sens       Date:  2017-05-02       Impact factor: 7.711

7.  Pathways of Metabolite-Related Damage to a Synthetic p53 Gene Exon 7 Oligonucleotide Using Magnetic Enzyme Bioreactor Beads and LC-MS/MS Sequencing.

Authors:  Spundana Malla; Karteek Kadimisetty; Di Jiang; Dharamainder Choudhary; James F Rusling
Journal:  Biochemistry       Date:  2018-05-23       Impact factor: 3.162

8.  Metabolites of Tobacco- and E-Cigarette-Related Nitrosamines Can Drive Cu2+-Mediated DNA Oxidation.

Authors:  Rumasha N T Kankanamage; Abhisek Brata Ghosh; Di Jiang; Karmel Gkika; Tia Keyes; Laura A Achola; Steven Suib; James F Rusling
Journal:  Chem Res Toxicol       Date:  2020-08-04       Impact factor: 3.739

9.  Microfluidic array for simultaneous detection of DNA oxidation and DNA-adduct damage.

Authors:  Boya Song; Min Shen; Di Jiang; Spundana Malla; Islam M Mosa; Dharamainder Choudhary; James F Rusling
Journal:  Analyst       Date:  2016-08-12       Impact factor: 4.616

Review 10.  Bystander signaling via oxidative metabolism.

Authors:  Humaira Aziz Sawal; Kashif Asghar; Matthias Bureik; Nasir Jalal
Journal:  Onco Targets Ther       Date:  2017-08-04       Impact factor: 4.147
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