Manish Jain1, Raksha Shah2, Betina Chandolia3, Ayush Mathur4, Yashwant Chauhan5, Jyoti Chawda6, Siddarth Mosby7, Sanjay Bhagalia7. 1. Associate Professor, Department of Oral and Maxillofacial Pathology, NIMS Dental College , Jaipur, India . 2. Professor and Ex HOD, Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital , Ahmadabad, India . 3. Senior Lecturer, Department of Oral and Maxillofacial Pathology, NIMS Dental College , Jaipur, India . 4. Senior Lecturer, Department of Orthodontics, NIMS Dental College , Jaipur, India . 5. Senior Lecturer, Department of Pedodontics, NIMS Dental College , Jaipur, India . 6. Professor and HOD, Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital , Ahmadabad, India . 7. Professor and Ex HOD, Department of Oral and Maxillofacial Pathology, NIMS Dental College , Jaipur, India .
Abstract
INTRODUCTION: Oral cancer is a challenging disease in Indian subcontinent because of increased use of tobacco and associated products. Although surgery is the main treatment modality, radiotherapy (RT) and chemotherapy (CT) are employed in inaccessible cases. Both RT & CT will result in painful and debilitating adverse effects in oral cavity e.g., mucositis, ulceration, dysgeusia, xerostomia and opportunistic infections. One of the most common opportunistic infection is caused by fungus Candida. AIM: Our aim was to investigate the incidence of oral colonization of Candida species with differentiation between carrier and infective state of the organism. We also investigate the effect of treatment modality (RT and CT) on the incidence of Candida, in oral cancer patients, undergoing RT and/or CT, in order to prevent and treat the Candida infection in a better way. MATERIALS AND METHODS: It was a cross-sectional case-control study; done in Gujarat, India. Fifty patients of oral cancer undergoing RT, CT alone or combined were investigated and compared with the healthy controls. The samples were collected from mid-dorsum of tongue by using imprint culture technique. The samples were inoculated on Sabouraud's dextrose agar medium and the organisms were identified by wet mount, germ tube test, chlamydospore formation and sugar fermentation tests. RESULTS: There was significant increase in oral Candida colonization from 20% in healthy controls to 70% in oral cancer patients undergoing RT and/or CT (p = 0.001, < 0.05). A significant increase in infective state of Candida (71.4%) was noted (p = 0.001, < 0.05) with predominance of non-albicans species of Candida, chiefly C. tropicalis (42.8%). CONCLUSION: RT and CT leads to increased oral colonization and infection by Candida with a shift towards growth of non-albicans species. As the pattern of candidal species infection is changing, such studies are important for better diagnosis and treatment planning to gain good control over the disease.
INTRODUCTION:Oral cancer is a challenging disease in Indian subcontinent because of increased use of tobacco and associated products. Although surgery is the main treatment modality, radiotherapy (RT) and chemotherapy (CT) are employed in inaccessible cases. Both RT & CT will result in painful and debilitating adverse effects in oral cavity e.g., mucositis, ulceration, dysgeusia, xerostomia and opportunistic infections. One of the most common opportunistic infection is caused by fungus Candida. AIM: Our aim was to investigate the incidence of oral colonization of Candida species with differentiation between carrier and infective state of the organism. We also investigate the effect of treatment modality (RT and CT) on the incidence of Candida, in oral cancerpatients, undergoing RT and/or CT, in order to prevent and treat the Candida infection in a better way. MATERIALS AND METHODS: It was a cross-sectional case-control study; done in Gujarat, India. Fifty patients of oral cancer undergoing RT, CT alone or combined were investigated and compared with the healthy controls. The samples were collected from mid-dorsum of tongue by using imprint culture technique. The samples were inoculated on Sabouraud's dextrose agar medium and the organisms were identified by wet mount, germ tube test, chlamydospore formation and sugar fermentation tests. RESULTS: There was significant increase in oral Candida colonization from 20% in healthy controls to 70% in oral cancerpatients undergoing RT and/or CT (p = 0.001, < 0.05). A significant increase in infective state of Candida (71.4%) was noted (p = 0.001, < 0.05) with predominance of non-albicans species of Candida, chiefly C. tropicalis (42.8%). CONCLUSION: RT and CT leads to increased oral colonization and infection by Candida with a shift towards growth of non-albicans species. As the pattern of candidal species infection is changing, such studies are important for better diagnosis and treatment planning to gain good control over the disease.
Entities:
Keywords:
Adverse effects of radiotherapy and Chemotherapy; Candida albicans; Opportunistic pathogen; Oral candidiasis
Authors: S W Redding; C W Bailey; J L Lopez-Ribot; W R Kirkpatrick; A W Fothergill; M G Rinaldi; T F Patterson Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2001-06
Authors: M Belazi; A Velegraki; T Koussidou-Eremondi; D Andreadis; S Hini; G Arsenis; C Eliopoulou; E Destouni; D Antoniades Journal: Oral Microbiol Immunol Date: 2004-12
Authors: Marta C Dahiya; Spencer W Redding; Rajiv S Dahiya; Tony Y Eng; William R Kirkpatrick; Brent J Coco; Lee C Sadkowski; A W Fothergill; Annette Waite; Michael G Rinaldi; Thomas F Patterson; Charles R Thomas Journal: Int J Radiat Oncol Biol Phys Date: 2003-09-01 Impact factor: 7.038
Authors: Máté Vadovics; Jemima Ho; Nóra Igaz; Róbert Alföldi; Dávid Rakk; Éva Veres; Balázs Szücs; Márton Horváth; Renáta Tóth; Attila Szücs; Andrea Csibi; Péter Horváth; László Tiszlavicz; Csaba Vágvölgyi; Joshua D Nosanchuk; András Szekeres; Mónika Kiricsi; Rhonda Henley-Smith; David L Moyes; Selvam Thavaraj; Rhys Brown; László G Puskás; Julian R Naglik; Attila Gácser Journal: mBio Date: 2022-01-04 Impact factor: 7.867