OBJECTIVE: The aim of this study was to verify the profile of Candida species responsible for colonizing and infecting the oral cavity of Brazilian patients undergoing radiotherapy (RT). STUDY DESIGN: Saliva samples were collected from 21 patients before, during, and immediately after RT. Each sample was distributed in agar Sabouraud dextrose/chlorophenicol and incubated at 37 degrees C for 18 hours. Emerging colonies were identified biochemically and through the germinative tube test. Patients were examined weekly to identify clinical candidiasis. RESULTS: Candida colonization continuously increased during RT. Infection occurred in 52% of the patients, and baseline colonization was higher in infected patients. A shift toward non-albicans species was observed in both infected and noninfected patients. CONCLUSIONS: RT leads to increased colonization and infection by Candida. The shift toward non-albicans species was unrelated to antifungal therapy. There may be epidemiological differences between infected and noninfected patients.
OBJECTIVE: The aim of this study was to verify the profile of Candida species responsible for colonizing and infecting the oral cavity of Brazilian patients undergoing radiotherapy (RT). STUDY DESIGN: Saliva samples were collected from 21 patients before, during, and immediately after RT. Each sample was distributed in agarSabouraud dextrose/chlorophenicol and incubated at 37 degrees C for 18 hours. Emerging colonies were identified biochemically and through the germinative tube test. Patients were examined weekly to identify clinical candidiasis. RESULTS: Candida colonization continuously increased during RT. Infection occurred in 52% of the patients, and baseline colonization was higher in infectedpatients. A shift toward non-albicans species was observed in both infected and noninfected patients. CONCLUSIONS: RT leads to increased colonization and infection by Candida. The shift toward non-albicans species was unrelated to antifungal therapy. There may be epidemiological differences between infected and noninfected patients.
Authors: Rajesh V Lalla; Marie C Latortue; Catherine H Hong; Anura Ariyawardana; Sandra D'Amato-Palumbo; Dena J Fischer; Andrew Martof; Ourania Nicolatou-Galitis; Lauren L Patton; Linda S Elting; Fred K L Spijkervet; Michael T Brennan Journal: Support Care Cancer Date: 2010-05-08 Impact factor: 3.603
Authors: Bruno C Jham; Patricia M Reis; Erika L Miranda; Renata C Lopes; Andre L Carvalho; Mark A Scheper; Addah R Freire Journal: Clin Oral Investig Date: 2007-09-18 Impact factor: 3.573
Authors: Ana Mañas; Laura Cerezo; Alejandro de la Torre; Mariola García; Héctor Alburquerque; Blanca Ludeña; Ana Ruiz; Ana Pérez; Ana Escribano; Aurea Manso; Luis Alberto Glaria Journal: Clin Transl Oncol Date: 2012-09-08 Impact factor: 3.405