Aminah Jatoi1, Rui Qin2, Daniel Satele2, Shaker Dakhil3, Pankaj Kumar4, David B Johnson3, Sachdev P Thomas4, Philip J Stella5, Jose Castillo6, Min Li7, Martin Fernandez-Zapico8. 1. Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. jatoi.aminah@mayo.edu. 2. Division of Biomedical Statistics, Mayo Clinic, Rochester, MN, USA. 3. Cancer Center of Kansas, Wichita, KS, USA. 4. Illinois Cancer Care - Peoria, Peoria, IL, USA. 5. Saint Joseph Mercy Hospital, Ann Arbor, MI, USA. 6. Geisinger Wyoming Valley, Wilkes-Barre, PA, USA. 7. University of Oklahoma, Oklahoma City, OK, USA. 8. Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA.
Abstract
BACKGROUND: Because the extant literature suggests wine increases appetite, this study sought to determine whether this effect could be observed in advanced cancer patients with appetite loss. METHODS:Advanced cancer patients with self-reported loss of appetite were randomly assigned to white wine with ≤15 % alcohol content twice a day for 3-4 weeks versus a nutritional supplement, such as Boost® or Ensure®. Patients assigned to wine were encouraged to also take a nutritional supplement, whereas patients assigned to the nutritional supplement arm were told to abstain completely from alcohol. Patient-reported outcomes were captured with a validated questionnaire to assess the primary endpoint of appetite improvement. RESULTS: A total of 141 patients (118 evaluable) were enrolled. Twenty-eight patients (48 %) in the wine arm reported an improvement in appetite at some point during the treatment period, whereas 22 patients (37 %) assigned to the nutritional supplement arm also reported improvement (p = 0.35). Other appetite-related questions and questionnaire items showed no statistically significant differences between treatment arms. In both arms, approximately 9 % of patients achieved weight stability (p = 0.98); median survival was not statistically different. Both interventions were well tolerated. CONCLUSION: As prescribed in this trial, wine does not improve appetite or weight in advanced cancer patients.
RCT Entities:
BACKGROUND: Because the extant literature suggests wine increases appetite, this study sought to determine whether this effect could be observed in advanced cancerpatients with appetite loss. METHODS: Advanced cancerpatients with self-reported loss of appetite were randomly assigned to white wine with ≤15 % alcohol content twice a day for 3-4 weeks versus a nutritional supplement, such as Boost® or Ensure®. Patients assigned to wine were encouraged to also take a nutritional supplement, whereas patients assigned to the nutritional supplement arm were told to abstain completely from alcohol. Patient-reported outcomes were captured with a validated questionnaire to assess the primary endpoint of appetite improvement. RESULTS: A total of 141 patients (118 evaluable) were enrolled. Twenty-eight patients (48 %) in the wine arm reported an improvement in appetite at some point during the treatment period, whereas 22 patients (37 %) assigned to the nutritional supplement arm also reported improvement (p = 0.35). Other appetite-related questions and questionnaire items showed no statistically significant differences between treatment arms. In both arms, approximately 9 % of patients achieved weight stability (p = 0.98); median survival was not statistically different. Both interventions were well tolerated. CONCLUSION: As prescribed in this trial, wine does not improve appetite or weight in advanced cancerpatients.
Entities:
Keywords:
Anorexia; Appetite; Cancer; Hunger; Weight loss
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