Yuan-Yuan Hao1, Hong-Wang Yuan1, Peng-Hua Fang1, Yu Zhang1, Yue-Xia Liao1, Chen Shen2, Dan Wang3, Ting-Ting Zhang1, Ping Bo4. 1. School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People's Republic of China. 2. Pediatric Cardiothoracic Surgical Department of Jiangsu Province Hospital, Nanjing, Jiangsu, The People's Republic of China. 3. Colorectal Surgical Department of Jiangsu Province Hospital, Nanjing, Jiangsu, The People's Republic of China. 4. School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People's Republic of China. Boping1955@hotmail.com.
Abstract
OBJECTIVE: To measure the amount of physical activity (PA) among obese adults, investigate the association between plasma orexin-A level and PA patterns, and explore the effect of orexin on the prevention and control of obesity. METHODS: Interviews were conducted in 218 participants (106 obese; 73 overweight; and 39 normal) who ranged in age between 18 and 70 years using a survey that included sociodemographic variables. The International Physical Activity Questionnaire (IPAQ-long version) was used to measure PA. A total of 178 participants agreed to submit blood sample collections, and plasma orexin-A content was measured by ELISA testing. RESULTS: The average level of orexin-A was 85.34 ± 42.85 ng/L in the obese group, 97.38 ± 36.72 ng/L in the overweight group, and 106.56 ± 52.09 ng/L in the control group, which was significantly different (P = 0.03). The concentration of plasma orexin-A correlated with the total PA (P = 0.000), moderate PA (obese = 0.007; overweight: P = 0.000; control: P = 0.000), and walking PA (P = 0.000) in all three groups. Working and domestic PAs were significantly associated with the plasma orexin-A level (P < 0.0001). CONCLUSIONS: The plasma orexin-A level was associated with PA in obese and overweight people, including many aspects of daily life, such as working, domestic work, and walking especially.
OBJECTIVE: To measure the amount of physical activity (PA) among obese adults, investigate the association between plasma orexin-A level and PA patterns, and explore the effect of orexin on the prevention and control of obesity. METHODS: Interviews were conducted in 218 participants (106 obese; 73 overweight; and 39 normal) who ranged in age between 18 and 70 years using a survey that included sociodemographic variables. The International Physical Activity Questionnaire (IPAQ-long version) was used to measure PA. A total of 178 participants agreed to submit blood sample collections, and plasma orexin-A content was measured by ELISA testing. RESULTS: The average level of orexin-A was 85.34 ± 42.85 ng/L in the obese group, 97.38 ± 36.72 ng/L in the overweight group, and 106.56 ± 52.09 ng/L in the control group, which was significantly different (P = 0.03). The concentration of plasma orexin-A correlated with the total PA (P = 0.000), moderate PA (obese = 0.007; overweight: P = 0.000; control: P = 0.000), and walking PA (P = 0.000) in all three groups. Working and domestic PAs were significantly associated with the plasma orexin-A level (P < 0.0001). CONCLUSIONS: The plasma orexin-A level was associated with PA in obese and overweight people, including many aspects of daily life, such as working, domestic work, and walking especially.
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