Michael Krämer1, Emanuele Scifoni1, Christoph Schuy1, Marta Rovituso1, Walter Tinganelli2, Andreas Maier1, Robert Kaderka1, Wilma Kraft-Weyrather1, Stephan Brons3, Thomas Tessonnier3, Katia Parodi4, Marco Durante2. 1. Biophysics, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstr. 1, 64291 Darmstadt, Germany. 2. Biophysics, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstr. 1, 64291 Darmstadt, Germany and Trento Institute for Fundamental Physics and Application (TIFPA-INFN), 38123, via Sommarive 14, Trento, Italy. 3. Heidelberger Ionenstrahl-Therapiezentrum (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany and Radioonkologie und Strahlentherapie, Universitätsklinikums Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. 4. Heidelberger Ionenstrahl-Therapiezentrum (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany; Radioonkologie und Strahlentherapie, Universitätsklinikums Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; and Ludwig-Maximilians-Universitaet Muenchen (LMU Munich), Department of Medical Physics, Am Coulombwall 1, 85748 Munich, Germany.
Abstract
PURPOSE: Modern facilities for actively scanned ion beam radiotherapy allow in principle the use of helium beams, which could present specific advantages, especially for pediatric tumors. In order to assess the potential use of these beams for radiotherapy, i.e., to create realistic treatment plans, the authors set up a dedicated (4)He beam model, providing base data for their treatment planning system TRiP98, and they have reported that in this work together with its physical and biological validations. METHODS: A semiempirical beam model for the physical depth dose deposition and the production of nuclear fragments was developed and introduced in TRiP98. For the biological effect calculations the last version of the local effect model was used. The model predictions were experimentally verified at the HIT facility. The primary beam attenuation and the characteristics of secondary charged particles at various depth in water were investigated using (4)He ion beams of 200 MeV/u. The nuclear charge of secondary fragments was identified using a ΔE/E telescope. 3D absorbed dose distributions were measured with pin point ionization chambers and the biological dosimetry experiments were realized irradiating a Chinese hamster ovary cells stack arranged in an extended target. RESULTS: The few experimental data available on basic physical processes are reproduced by their beam model. The experimental verification of absorbed dose distributions in extended target volumes yields an overall agreement, with a slight underestimation of the lateral spread. Cell survival along a 4 cm extended target is reproduced with remarkable accuracy. CONCLUSIONS: The authors presented a simple simulation model for therapeutical (4)He beams which they introduced in TRiP98, and which is validated experimentally by means of physical and biological dosimetries. Thus, it is now possible to perform detailed treatment planning studies with (4)He beams, either exclusively or in combination with other ion modalities.
PURPOSE: Modern facilities for actively scanned ion beam radiotherapy allow in principle the use of helium beams, which could present specific advantages, especially for pediatric tumors. In order to assess the potential use of these beams for radiotherapy, i.e., to create realistic treatment plans, the authors set up a dedicated (4)He beam model, providing base data for their treatment planning system TRiP98, and they have reported that in this work together with its physical and biological validations. METHODS: A semiempirical beam model for the physical depth dose deposition and the production of nuclear fragments was developed and introduced in TRiP98. For the biological effect calculations the last version of the local effect model was used. The model predictions were experimentally verified at the HIT facility. The primary beam attenuation and the characteristics of secondary charged particles at various depth in water were investigated using (4)He ion beams of 200 MeV/u. The nuclear charge of secondary fragments was identified using a ΔE/E telescope. 3D absorbed dose distributions were measured with pin point ionization chambers and the biological dosimetry experiments were realized irradiating a Chinese hamster ovary cells stack arranged in an extended target. RESULTS: The few experimental data available on basic physical processes are reproduced by their beam model. The experimental verification of absorbed dose distributions in extended target volumes yields an overall agreement, with a slight underestimation of the lateral spread. Cell survival along a 4 cm extended target is reproduced with remarkable accuracy. CONCLUSIONS: The authors presented a simple simulation model for therapeutical (4)He beams which they introduced in TRiP98, and which is validated experimentally by means of physical and biological dosimetries. Thus, it is now possible to perform detailed treatment planning studies with (4)He beams, either exclusively or in combination with other ion modalities.
Authors: L Volz; C-A Collins-Fekete; E Bär; S Brons; C Graeff; R P Johnson; A Runz; C Sarosiek; R W Schulte; J Seco Journal: Phys Med Biol Date: 2021-11-29 Impact factor: 3.609
Authors: M Fischetti; G Baroni; G Battistoni; G Bisogni; P Cerello; M Ciocca; P De Maria; M De Simoni; B Di Lullo; M Donetti; Y Dong; A Embriaco; V Ferrero; E Fiorina; G Franciosini; F Galante; A Kraan; C Luongo; M Magi; C Mancini-Terracciano; M Marafini; E Malekzadeh; I Mattei; E Mazzoni; R Mirabelli; A Mirandola; M Morrocchi; S Muraro; V Patera; F Pennazio; A Schiavi; A Sciubba; E Solfaroli Camillocci; G Sportelli; S Tampellini; M Toppi; G Traini; S M Valle; B Vischioni; V Vitolo; A Sarti Journal: Sci Rep Date: 2020-11-26 Impact factor: 4.379