Literature DB >> 27032821

Deuterated drugs draw heavier backing.

Asher Mullard.   

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Year:  2016        PMID: 27032821     DOI: 10.1038/nrd.2016.63

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


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  23 in total

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Journal:  Acc Chem Res       Date:  2016-08-03       Impact factor: 22.384

2.  Conversion of Methyl Ketones and Methyl Sulfones into α-Deutero-α,α-Difluoromethyl Ketones and α-Deutero-α,α-Difluoromethyl Sulfones in Three Synthetic Steps.

Authors:  Munia F Sowaileh; Changho Han; Robert A Hazlitt; Eun Hoo Kim; Jinu P John; David A Colby
Journal:  Tetrahedron Lett       Date:  2016-12-21       Impact factor: 2.415

3.  From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators.

Authors:  Haibo Xie; Ka Yang; Gabrielle N Winston-McPherson; Donnie S Stapleton; Mark P Keller; Alan D Attie; Kerry A Smith; Weiping Tang
Journal:  Eur J Med Chem       Date:  2020-08-04       Impact factor: 6.514

4.  Nickel-Catalyzed Reduction of Secondary and Tertiary Amides.

Authors:  Bryan J Simmons; Marie Hoffmann; Jaeyeon Hwang; Moritz K Jackl; Neil K Garg
Journal:  Org Lett       Date:  2017-03-24       Impact factor: 6.005

5.  Locomotor effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in mice: psychostimulant effects, stereotypy, and sensitization.

Authors:  Michael D Berquist; Sebastian Leth-Petersen; Jesper Langgaard Kristensen; William E Fantegrossi
Journal:  Psychopharmacology (Berl)       Date:  2019-11-15       Impact factor: 4.530

6.  Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction.

Authors:  Zuyuan Shen; Shilei Zhang; Huihui Geng; Jiarui Wang; Xinyu Zhang; Anqi Zhou; Cheng Yao; Xiaobei Chen; Wei Wang
Journal:  Org Lett       Date:  2019-01-07       Impact factor: 6.005

7.  Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach.

Authors:  Yueteng Zhang; Peng Ji; Yue Dong; Yongyi Wei; Wei Wang
Journal:  ACS Catal       Date:  2020-01-23       Impact factor: 13.084

8.  Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.

Authors:  Laura Friggeri; Tatiana Y Hargrove; Girish Rachakonda; Anna L Blobaum; Paxtyn Fisher; Gabriel Melo de Oliveira; Cristiane França da Silva; Maria de Nazaré C Soeiro; W David Nes; Craig W Lindsley; Fernando Villalta; F Peter Guengerich; Galina I Lepesheva
Journal:  J Med Chem       Date:  2018-11-30       Impact factor: 7.446

9.  Organophotocatalytic selective deuterodehalogenation of aryl or alkyl chlorides.

Authors:  Yanjun Li; Ziqi Ye; Yu-Mei Lin; Yan Liu; Yumeng Zhang; Lei Gong
Journal:  Nat Commun       Date:  2021-05-17       Impact factor: 14.919

10.  Formyl-selective deuteration of aldehydes with D2O via synergistic organic and photoredox catalysis.

Authors:  Jianyang Dong; Xiaochen Wang; Zhen Wang; Hongjian Song; Yuxiu Liu; Qingmin Wang
Journal:  Chem Sci       Date:  2019-12-04       Impact factor: 9.825

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