Literature DB >> 28339212

Nickel-Catalyzed Reduction of Secondary and Tertiary Amides.

Bryan J Simmons1, Marie Hoffmann1, Jaeyeon Hwang1, Moritz K Jackl1, Neil K Garg1.   

Abstract

The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of lactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant α-deuterated amines.

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Year:  2017        PMID： 28339212      PMCID： PMC5476940          DOI： 10.1021/acs.orglett.7b00683

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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