Literature DB >> 27023676

Navigating pleiotropy in precision medicine: pharmacogenes from trauma to behavioral health.

Vicki Oberg1, Jerome Differding2, Morgan Fisher3, Lindsay Hines4, Russell A Wilke5.   

Abstract

A strong emerging principle in the field of precision medicine is that variation in any one pharmacogene may impact clinical outcome for more than one drug. Variants tested in the acute care setting often have downstream implications for other drugs impacting chronic disease management. A flexible framework is needed as clinicians and scientists move toward deploying automated decision support for gene-based drug dosing in electronic medical records.

Entities:  

Keywords:  Best Practice Advisory; clinical decision support; drug metabolizing enzyme; electronic medical record; individualized medicine; personalized medicine; pharmacodynamics; pharmacogenes; pharmacogenetics; pharmacogenomics; pharmacokinetics; pleiotropy; precision medicine

Mesh：

Year:  2016        PMID： 27023676     DOI： 10.2217/pgs.16.6

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.533


  5 in total

1.  PleioNet: a web-based visualization tool for exploring pleiotropy across complex traits.

Authors:  X Raymond Gao; Hua Huang
Journal:  Bioinformatics       Date:  2019-10-15       Impact factor: 6.937

2.  CYP2C19 genotype, physician prescribing pattern, and risk for long QT on serotonin selective reuptake inhibitors.

Authors:  Natasha Petry; Roxana Lupu; Ahmed Gohar; Eric A Larson; Carmen Peterson; Vanessa Williams; Jing Zhao; Russell A Wilke; Lindsay J Hines
Journal:  Pharmacogenomics       Date:  2019-04-15       Impact factor: 2.533

Review 3.  The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting.

Authors:  L H Cavallari; A L Beitelshees; K V Blake; L G Dressler; J D Duarte; A Elsey; J N Eichmeyer; P E Empey; J P Franciosi; J K Hicks; A M Holmes; Ljb Jeng; C R Lee; J J Lima; N A Limdi; J Modlin; A O Obeng; N Petry; V M Pratt; T C Skaar; S Tuteja; D Voora; M Wagner; K W Weitzel; R A Wilke; J F Peterson; J A Johnson
Journal:  Clin Transl Sci       Date:  2017-03-14       Impact factor: 4.689

Review 4.  CYP2C19 genotype-guided antiplatelet therapy: promises and pitfalls.

Authors:  Moataz Ellithi; Jordan Baye; Russell A Wilke
Journal:  Pharmacogenomics       Date:  2020-07-29       Impact factor: 2.533

5.  Application of pharmacogenomics for trauma and critical care patients: A case report.

Authors:  Kevin McFadgen; Natisha Jensen; Pramod B Mahajan
Journal:  Trauma Case Rep       Date:  2019-11-20
  5 in total

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