| Literature DB >> 27023224 |
Xiao-Yan Zhang1, Hui-Fu Wang2, Meng-Shan Tan1, Yu Wan1, Ling-Li Kong3, Zhan-Jie Zheng3, Chen-Chen Tan1, Wei Zhang4, Zi-Xuan Wang1, Lin Tan5, Teng Jiang6, Lan Tan7,8, Jin-Tai Yu9,10.
Abstract
The disrupted-in-schizophrenia-1 (DISC1) is a candidate gene for psychiatric diseases and plays various roles in brain development. It has been reported as a candidate gene for Alzheimer's disease (AD) in a recent large genome-wide association study in Caucasians. To explore the associations between DISC1 and AD, we performed a case-control study including 2318 subjects in Northern Han Chinese. We found that one single nucleotide polymorphism (rs6675281) was associated with the risk of late-onset Alzheimer's disease (LOAD) in northern Han Chinese population. As for rs821616 and rs3738401, no association was detected with LOAD. In conclusion, DISC1 increased the risk for LOAD in northern Han Chinese population.Entities:
Keywords: Alzheimer’s disease; Association; DISC1; Polymorphism
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Year: 2016 PMID： 27023224 DOI： 10.1007/s12035-016-9881-7
Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590