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Literature DB >> 19303839

DISC1 partners with GSK3beta in neurogenesis.

Abstract

The protein DISC1, encoded by a gene implicated in schizophrenia susceptibility, regulates the development of postmitotic neurons. Mao et al. (2009) now report that DISC1 also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3beta/beta-catenin pathway, providing new insights into how susceptibility genes may contribute to the etiology of psychiatric disorders.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19303839 PMCID： PMC6188698 DOI： 10.1016/j.cell.2009.03.005

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

9 in total

Review 1. Neurobiology of schizophrenia.

Authors: Christopher A Ross; Russell L Margolis; Sarah A J Reading; Mikhail Pletnikov; Joseph T Coyle
Journal: Neuron Date: 2006-10-05 Impact factor: 17.173

Review 2. Mechanisms and functional implications of adult neurogenesis.

Authors: Chunmei Zhao; Wei Deng; Fred H Gage
Journal: Cell Date: 2008-02-22 Impact factor: 41.582

3. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.

Authors: Atsushi Kamiya; Ken-ichiro Kubo; Toshifumi Tomoda; Manabu Takaki; Richard Youn; Yuji Ozeki; Naoya Sawamura; Una Park; Chikako Kudo; Masako Okawa; Christopher A Ross; Mary E Hatten; Kazunori Nakajima; Akira Sawa
Journal: Nat Cell Biol Date: 2005-11-20 Impact factor: 28.824

Review 4. The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave.

Authors: S Marenco; D R Weinberger
Journal: Dev Psychopathol Date: 2000

5. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.

Authors: Xin Duan; Jay H Chang; Shaoyu Ge; Regina L Faulkner; Ju Young Kim; Yasuji Kitabatake; Xiao-bo Liu; Chih-Hao Yang; J Dedrick Jordan; Dengke K Ma; Cindy Y Liu; Sundar Ganesan; Hwai-Jong Cheng; Guo-li Ming; Bai Lu; Hongjun Song
Journal: Cell Date: 2007-09-06 Impact factor: 41.582

6. Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain.

Authors: Regina L Faulkner; Mi-Hyeon Jang; Xiao-Bo Liu; Xin Duan; Kurt A Sailor; Ju Young Kim; Shaoyu Ge; Edward G Jones; Guo-li Ming; Hongjun Song; Hwai-Jong Cheng
Journal: Proc Natl Acad Sci U S A Date: 2008-09-09 Impact factor: 11.205

Review 7. Akt/GSK3 signaling in the action of psychotropic drugs.

Authors: Jean-Martin Beaulieu; Raul R Gainetdinov; Marc G Caron
Journal: Annu Rev Pharmacol Toxicol Date: 2009 Impact factor: 13.820

8. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors.

Authors: Anjen Chenn; Christopher A Walsh
Journal: Science Date: 2002-07-19 Impact factor: 47.728

Review 9. The DISC locus in psychiatric illness.

Authors: J E Chubb; N J Bradshaw; D C Soares; D J Porteous; J K Millar
Journal: Mol Psychiatry Date: 2007-10-02 Impact factor: 15.992

9 in total

27 in total

Review 1. Cellular reprogramming: recent advances in modeling neurological diseases.

Authors: Guo-Li Ming; Oliver Brüstle; Alysson Muotri; Lorenz Studer; Marius Wernig; Kimberly M Christian
Journal: J Neurosci Date: 2011-11-09 Impact factor: 6.167

2. Questions about DISC1 as a genetic risk factor for schizophrenia.

Authors: P F Sullivan
Journal: Mol Psychiatry Date: 2013-10 Impact factor: 15.992

3. Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.

Authors: Ju Young Kim; Cindy Y Liu; Fengyu Zhang; Xin Duan; Zhexing Wen; Juan Song; Emer Feighery; Bai Lu; Dan Rujescu; David St Clair; Kimberly Christian; Joseph H Callicott; Daniel R Weinberger; Hongjun Song; Guo-li Ming
Journal: Cell Date: 2012-03-02 Impact factor: 41.582

DISC1 partners with GSK3beta in neurogenesis.

Review 1. Neurobiology of schizophrenia.

Review 2. Mechanisms and functional implications of adult neurogenesis.

3. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.

Review 4. The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave.

5. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.

6. Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain.

Review 7. Akt/GSK3 signaling in the action of psychotropic drugs.

8. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors.

Review 9. The DISC locus in psychiatric illness.

Review 1. Cellular reprogramming: recent advances in modeling neurological diseases.

2. Questions about DISC1 as a genetic risk factor for schizophrenia.

3. Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.

Review 4. Functions and dysfunctions of adult hippocampal neurogenesis.

5. Fibroblast Growth Factor 14 Modulates the Neurogenesis of Granule Neurons in the Adult Dentate Gyrus.

6. Novel functions of GABA signaling in adult neurogenesis.

7. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.

8. The role of glycogen synthase kinase-3 signaling in neurodevelopment and fragile X syndrome.

Review 9. Activity-dependent signaling mechanisms regulating adult hippocampal neural stem cells and their progeny.

10. Association of DISC1 Polymorphisms with Late-Onset Alzheimer's Disease in Northern Han Chinese.