Shi Shi Lv1, Ji Ying Wang2, Xiao Qian Wang1, Yan Wang1, Yong Xu3. 1. Department of Endocrinology, The People's Hospital of Deyang City, Deyang, 618000, Sichuan, China. 2. Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan, China. 3. Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan, China. Lss219219@sina.cn.
Abstract
OBJECTIVE: To assess the correlation between serum 25-hydroxy vitamin D [25(OH)D] status and outcomes of in vitro fertilization (IVF) in infertile women through review systematically. METHODS: We used Embase, Pubmed, and Cochrane database to identify all studies that assessed the correlation between serum vitamin D levels and IVF outcomes in infertile women up until 30 June 2015, with the restricted language of English. We included studies that compared IVF outcomes between infertile women vitamin D <20 ng/ml and vitamin D ≥20 ng/ml. The results were summarized using Stata 12.0 software. For studies reported dichotomous outcomes (clinical pregnancy rate and live birth rate), we pooled the relative risks ratios (RRs) and 95 % confidence intervals (CIs) in a random effects model. RESULTS: Our search resulted in the retrieval and screening of 134 studies. Of those, five studies were included in our meta-analysis. The risk for lower clinical pregnancy rate was not significantly increased in the deficient group (RR 0.88, 95 % CI 0.69-1.11). Lower vitamin D status was associated with lower live birth rate (RR 0.76, 95 % CI 0.61-0.93). CONCLUSION: There is no significant correlation between deficient serum vitamin D level and lower clinical pregnancy rate in infertile woman undergoing in vitro fertilization. On the other hand, deficient vitamin D level was related to lower live birth rate.
OBJECTIVE: To assess the correlation between serum 25-hydroxy vitamin D [25(OH)D] status and outcomes of in vitro fertilization (IVF) in infertile women through review systematically. METHODS: We used Embase, Pubmed, and Cochrane database to identify all studies that assessed the correlation between serum vitamin D levels and IVF outcomes in infertile women up until 30 June 2015, with the restricted language of English. We included studies that compared IVF outcomes between infertile womenvitamin D <20 ng/ml and vitamin D ≥20 ng/ml. The results were summarized using Stata 12.0 software. For studies reported dichotomous outcomes (clinical pregnancy rate and live birth rate), we pooled the relative risks ratios (RRs) and 95 % confidence intervals (CIs) in a random effects model. RESULTS: Our search resulted in the retrieval and screening of 134 studies. Of those, five studies were included in our meta-analysis. The risk for lower clinical pregnancy rate was not significantly increased in the deficient group (RR 0.88, 95 % CI 0.69-1.11). Lower vitamin D status was associated with lower live birth rate (RR 0.76, 95 % CI 0.61-0.93). CONCLUSION: There is no significant correlation between deficient serum vitamin D level and lower clinical pregnancy rate in infertile woman undergoing in vitro fertilization. On the other hand, deficient vitamin D level was related to lower live birth rate.
Authors: Vitor As Deriquehem; Roberto A Antunes; Mila W Reginatto; Ana C Mancebo; Patricia Areas; Enrrico Bloise; Maria do Carmo B de Souza; Tania M Ortiga-Carvalho Journal: JBRA Assist Reprod Date: 2016-08-01
Authors: Stefan Pilz; Armin Zittermann; Rima Obeid; Andreas Hahn; Pawel Pludowski; Christian Trummer; Elisabeth Lerchbaum; Faustino R Pérez-López; Spyridon N Karras; Winfried März Journal: Int J Environ Res Public Health Date: 2018-10-12 Impact factor: 3.390