Chongjuan Gu1, Hongxia Gong2, Zheng Zhang3, Zhao Yang1, Yongxin Ma4. 1. Department of Medical Genetics and Division of Human Morbid Genomics, West China Hospital, Sichuan University, 1st Keyuan 4 Lu, High-Tech Zone, Chengdu, 610041, China. 2. Provincial Key Laboratory for Molecular Medicine of Major Diseases and Prevention and Treatment with Traditional Chinese Medicine of Gansu Colleges and Universities, Gansu University of Chinese Medicine, Lanzhou, China. 3. Department of Obstetrics and Gynecology, reproductive medicine centre, Southwest Hospital, Third Military Medical University, Chongqing, China. 4. Department of Medical Genetics and Division of Human Morbid Genomics, West China Hospital, Sichuan University, 1st Keyuan 4 Lu, High-Tech Zone, Chengdu, 610041, China. mayongxin@gmail.com.
Abstract
PURPOSE: It has been reported single-nucleotide polymorphisms (SNPs) of the IL-10 promoter might be associated with the susceptibility to recurrent pregnancy loss (RPL). Owing to the inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the IL-10 promoter SNPs and RPL risk. METHODS: A systematic search of studies on the association of the three SNPs with RPL was conducted in PubMed and Embase. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to pool the effect size. RESULT: Eleven case-control studies on rs1800896, seven studies on rs1800871, and eight studies on rs1800872 were included. A significant association was identified between IL-10 rs1800896 with RPL risk (G versus A: OR = 1.21, 95 % CI 1.09-1.35). No evidence of association was found between rs1800871 and RPL when restricted to those studies in Hardy-Weinberg equilibrium in controls (T versus C: OR = 1.25, 95 % CI 0.76-2.06). No statistical association was demonstrated between rs1800872 and RPL (C versus A: OR = 1.08, 95 % CI 0.83-1.42). CONCLUSIONS: IL-10 rs1800896 significantly increases the risk of RPL, while rs1800872 is not correlated with RPL risk. No significant association is demonstrated between rs1800871 and RPL risk but this requires further investigation.
PURPOSE: It has been reported single-nucleotide polymorphisms (SNPs) of the IL-10 promoter might be associated with the susceptibility to recurrent pregnancy loss (RPL). Owing to the inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the IL-10 promoter SNPs and RPL risk. METHODS: A systematic search of studies on the association of the three SNPs with RPL was conducted in PubMed and Embase. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to pool the effect size. RESULT: Eleven case-control studies on rs1800896, seven studies on rs1800871, and eight studies on rs1800872 were included. A significant association was identified between IL-10 rs1800896 with RPL risk (G versus A: OR = 1.21, 95 % CI 1.09-1.35). No evidence of association was found between rs1800871 and RPL when restricted to those studies in Hardy-Weinberg equilibrium in controls (T versus C: OR = 1.25, 95 % CI 0.76-2.06). No statistical association was demonstrated between rs1800872 and RPL (C versus A: OR = 1.08, 95 % CI 0.83-1.42). CONCLUSIONS: IL-10 rs1800896 significantly increases the risk of RPL, while rs1800872 is not correlated with RPL risk. No significant association is demonstrated between rs1800871 and RPL risk but this requires further investigation.
Entities:
Keywords:
Gene polymorphism; Interleukin-10; Meta-analysis; Recurrent pregnancy loss
Authors: John H Tinsley; Sanique South; Valorie L Chiasson; Brett M Mitchell Journal: Am J Physiol Regul Integr Comp Physiol Date: 2010-01-06 Impact factor: 3.619